Patents by Inventor Linas Kudzma

Linas Kudzma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of purifying crude sevoflurane
    Patent number: 10035745
    Abstract: A method of purifying crude sevoflurane comprising (i) providing crude sevoflurane and an aqueous base to a first centrifugal separator, wherein the crude sevoflurane comprises sevoflurane and hexafluoroisopropanol; (ii) mixing the crude sevoflurane and the aqueous base in the first centrifugal separator; and (iii) separating the sevoflurane from the aqueous base in the first centrifugal separator, thereby purifying the crude sevoflurane.
    Type: Grant
    Filed: July 30, 2016
    Date of Patent: July 31, 2018
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Yongxian Zeng, Hong-Chang Lee, Linas Kudzma
  • Methods for cleaning distilling columns
    Patent number: 9102604
    Abstract: A method for cleaning a distilling column includes providing a distilling column including a packing containing nickel and adding hydrochloric acid to the distilling column to wash at least a portion of the packing, thereby cleaning the distilling column.
    Type: Grant
    Filed: February 15, 2010
    Date of Patent: August 11, 2015
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Leonid A. Rozov, Linas Kudzma, Hong-Chang Lee, Ronald Bell
  • Process for the manufacturing of sevoflurane
    Patent number: 8729313
    Abstract: The present invention provides a method for forming sevoflurane comprising (i) combining chlorosevo ether, a nucleophilic fluoride reagent, and a solvent comprising sevoflurane to form an initial reaction mixture and (ii) reacting the initial reaction mixture to form additional sevoflurane relative to the amount of sevoflurane present in the initial reaction mixture. The present disclosure is also directed to a method for forming sevoflurane, comprising: initiating a reaction between chlorosevo ether and a nucleophilic fluoride reagent in an initial reaction mixture further comprising a solvent comprising sevoflurane, thereby forming additional sevoflurane relative to the amount of sevoflurane present in the initial reaction mixture.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: May 20, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Linas Kudzma, Ronald Bell, Yongxian Zeng, Leonid A. Rozov
  • PROCESS FOR THE MANUFACTURING OF SEVOFLURANE
    Publication number: 20130046117
    Abstract: The present invention provides a method for forming sevoflurane comprising (i) combining chlorosevo ether, a nucleophilic fluoride reagent, and a solvent comprising sevoflurane to form an initial reaction mixture and (ii) reacting the initial reaction mixture to form additional sevoflurane relative to the amount of sevoflurane present in the initial reaction mixture. The present disclosure is also directed to a method for forming sevoflurane, comprising: initiating a reaction between chlorosevo ether and a nucleophilic fluoride reagent in an initial reaction mixture further comprising a solvent comprising sevoflurane, thereby forming additional sevoflurane relative to the amount of sevoflurane present in the initial reaction mixture.
    Type: Application
    Filed: August 15, 2011
    Publication date: February 21, 2013
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Linas Kudzma, Ronald Bell, Yongxian Zeng, Leonid A. Rozov