Abstract: Disclosed are a pyrimidine carboxamide compound and an application thereof. Further provided are a pyrimidine carboxamide compound represented by formula (I), or a tautomer, mesomer, racemate, enantiomer, or diastereomer thereof, a mixture form thereof, or a pharmaceutically acceptable salt thereof. The compound can be used as a Vanin enzyme inhibitor, and can be used to prepare a drug for treating various diseases, including Crohn's disease, ulcerative colitis, and so on.

Abstract: A pharmaceutically acceptable salt type and crystal form of a compound of formula (I), and a preparation method of the compound and an application thereof are provided.

Abstract: An IRAK4 inhibitor composition, a preparation method and use thereof. The composition comprises: (i) a compound of formula I, a stereoisomer, a solvate or a pharmaceutically acceptable salt thereof; (ii) a diluent; (iii) a disintegrant; and (iv) a lubricant.

Abstract: The present invention relates to a salt form and a crystal form of a Vanin enzyme inhibitor represented by formula I, a method for preparing same, and use thereof. The salt form is a salt formed by the compound represented by formula I with an acid, and the crystal form is selected from a crystal form A, a crystal form B, a crystal form C, and a crystal form D of an L-tartrate of the compound represented by formula I. The salt of the compound represented by formula I of the present invention features high stability and good water solubility, which is conducive to the enhancement of oral absorbability, thus improving the bioavailability. The crystal form of the present invention features high stability, good solubility, and low hygroscopicity, and has promising prospects for being developed into medicaments.

Abstract: Provided herein is the use of indazole compounds represented by formula (I), or a stereoisomer, a racemate, a tautomer, an isotopically labeled compound, a prodrug, or a pharmaceutically acceptable salt thereof, in the manufacture of medicament for treating and/or preventing psoriasis.

Abstract: Disclosed in the present invention are polymorphic forms of a compound and a preparation method therefor and an application thereof. A crystal form III of a compound A uses Cu—K? radiation, and X-ray powder diffraction expressed at 2? angles has characteristic peaks at 12.15±0.20°, 15.98±0.20°, 16.62±0.20°, 17.14±0.20°, 24.32±0.20°, and 26.08±0.20°. A crystal form VII of the compound A uses Cu—K? radiation, and X-ray powder diffraction expressed at 2? angles has characteristic peaks at 12.94±0.20°, 14.41±0.20°, 15.64±0.20°, 17.25±0.20°, 21.75±0.20°, and 24.23±0.20°. The polymorphic forms prepared by the present invention are good in stability, and can be stably stored under the conditions of high temperature and low relative humidity.

Abstract: A pyrimidine carboxamide compound as shown in formula I, or a tautomer, mesomer, racemate, enantiomer and diastereomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, which can be used as a Vanin enzyme inhibitor, and can be used to prepare a medicament for treating various conditions, including Crohn's disease and ulcerative colitis.

Abstract: Disclosed are a pyrimidine carboxamide compound and an application thereof. Further provided are a pyrimidine carboxamide compound represented by formula (I), or a tautomer, mesomer, racemate, enantiomer, or diastereomer thereof, a mixture form thereof, or a pharmaceutically acceptable salt thereof. The compound can be used as a Vanin enzyme inhibitor, and can be used to prepare a drug for treating various diseases, including Crohn's disease, ulcerative colitis, and so on.

Abstract: A heterocyclic compound as represented by formula I, a preparation method therefor, a pharmaceutical composition comprising same and use thereof are provided. The heterocyclic compound can be used as a complement factor B inhibitor and is used for preparing a medicament for treating a disease related to abnormal activation of the complement system or occur in normal functioning of the complement system. The heterocyclic compound can be used as a therapeutic agent for a disease related to inflammation and immunity.

Abstract: A piperidinyl-containing heterocyclic compound is represented by formula (I). The compound can be used for treating a condition or disease related to complement alternative pathway activation by inhibiting/regulating complement factor B.