Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.

Abstract: The present invention relates anti-HIV therapies and prophylaxis. Specifically, the invention relates to broadly neutralizing antibodies against HIV-1, nucleic acids encoding these antibodies, vectors comprising the nucleic acids and cells and pharmaceutical compositions Comprising said vectors and/or antibodies. The present invention also relates to use of the antibodies and/or vectors for the treatment and/or prevention of HIV-1 infection in a subject. Furthermore, the invention also relates to a kit containing the antibodies of the invention.

Abstract: The present invention relates anti-HIV therapies and prophylaxis. Specifically, the invention relates to broadly neutralizing antibodies against HIV-1, nucleic acids encoding these antibodies, vectors comprising the nucleic acids and cells and pharmaceutical compositions Comprising said vectors and/or antibodies. The present invention also relates to use of the antibodies and/or vectors for the treatment and/or prevention of HIV-1 infection in a subject. Furthermore, the invention also relates to a kit containing the antibodies of the invention.

Abstract: The present invention relates anti-HIV therapies and prophylaxis. Specifically, the invention relates to broadly neutralizing antibodies against HIV-1, nucleic acids encoding these antibodies, vectors comprising the nucleic acids and cells and pharmaceutical compositions Comprising said vectors and/or antibodies. The present invention also relates to use of the antibodies and/or vectors for the treatment and/or prevention of HIV-1 infection in a subject. Furthermore, the invention also relates to a kit containing the antibodies of the invention.

Abstract: Described are devices for retaining a nonporous substrate, as well as methods for their use, the devices comprising a housing for receiving the nonporous substrate, a removable well insert attached to the housing and adjacently coplanar to the substrate, the well insert having at least one opening that, together with the substrate, defines a well, and means for exerting a force against the substrate such that the substrate engages the well insert with sufficient force to attain a fluid-tight seal in the well.

Abstract: The invention provides, in one embodiment, a device for performing scrub testing on a plurality of samples simultaneously, including a plurality of scrubbing devices. A stage is provided which positions the plurality of samples in contact with the plurality of scrubbing devices. The scrubbing devices can individually be provided with different weights to produce different forces on the samples. A motion producing device produces one or both of linear and rotational motion between the brushes and the samples. The scrubbing devices are held in the stage so as move freely vertically.

Abstract: Described are devices for retaining a nonporous substrate, as well as methods for their use, the devices comprising a housing for receiving the nonporous substrate, a removable well insert attached to the housing and adjacently coplanar to the substrate, the well insert having at least one opening that, together with the substrate, defines a well, and means for exerting a force against the substrate such that the substrate engages the well insert with sufficient force to attain a fluid-tight seal in the well.

Abstract: The invention provides, in one embodiment, a device for performing scrub testing on a plurality of samples simultaneously, including a plurality of scrubbing devices. A stage is provided which positions the plurality of samples in contact with the plurality of scrubbing devices. The scrubbing devices can individually be provided with different weights to produce different forces on the samples. A motion producing device produces one or both of linear and rotational motion between the brushes and the samples. The scrubbing devices are held in the stage so as move freely vertically.

Abstract: Solved three-dimensional crystal structures of a human LXR ligand binding domain polypeptide in complex with one or more of a ligand and a coactivator polypeptide is disclosed. Contact points between the LXR and the ligands are also disclosed. Additionally, methods of designing modulators of the biological activity of LXR, and other LXR ligand binding domain polypeptides, are also disclosed.