Patents by Inventor Linda B. Bloom

Linda B. Bloom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 7037687
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: May 2, 2006
    Assignees: Arizona Board of Regents, University of Alberta
    Inventors: Peter Williams, Mark A. Hayes, Seth D. Rose, Linda B. Bloom, Linda J. Reha-Krantz, Vincent B. Pizziconi
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Publication number: 20030138809
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: August 28, 2002
    Publication date: July 24, 2003
    Inventors: Peter Williams, Mark A. Hayes, Seth D. Rose, Linda B. Bloom, Linda J. Reha-Krantz, Vincent B. Pizziconi