Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Abstract: The invention herein discloses a full-coverage-controlling undergarment configured to extend from above the navel up to the mid torso, even up to about below the breast region, to below the creases where a leg of a wearer joins the abdomen in front and below the buttocks in the rear. As part of the undergarment, front leg-hole defining edges are configured with a shallow arc adapted to enable the pair of front leg-hole defining edges to run along a natural crease where a leg of a wearer joins the abdomen. A pair of opposing leg-hole defining edges are configured with a straight edge adapted to enable the buttocks of a wearer to be contained within the straight edge. Moisture and heat management material is provided in the undergarment to ameliorate skin issues that are endemic to skin on skin contact resulting from a pannus and/or excess skin folds.

Abstract: The device comprises a sheet of paper or card, having a slit formed therein. The slit makes an inverted U-shape, having left and right leg portions, and a cross-bar. The slit divides the sheet into a front panel, on which a greetings message can be written or printed, and a fixing-loop, which slips over the neck of the bottle. The vertical length of the legs of the slit is shorter than the width between the legs, whereby the device comes to rest on the bottle, with the neck of the bottle touching the inside of the front panel and the back of the fixing-loop. The bottle does not touch the legs of the slit. An envelope for the device is also disclosed.

Abstract: The device comprises a sheet of paper or card, having a slit formed therein. The slit makes an inverted U-shape, having left and right leg portions, and a cross-bar. The slit divides the sheet into a front panel, on which a greetings message can be written or printed, and a fixing-loop, which slips over the neck of the bottle. The vertical length of the legs of the slit is shorter than the width between the legs, whereby the device comes to rest on the bottle, with the neck of the bottle touching the inside of the front panel and the back of the fixing-loop. The bottle does not touch the legs of the slit. An envelope for the device is also disclosed.

Abstract: The device comprises a sheet of paper or card, having a slit formed therein. The slit makes an inverted U-shape, having left and right leg portions, and a cross-bar. The slit divides the sheet into a front panel, on which a greetings message can be written or printed, and a fixing-loop, which slips over the neck of the bottle. The vertical length of the legs of the slit is shorter than the width between the legs, whereby the device comes to rest on the bottle, with the neck of the bottle touching the inside of the front panel and the back of the fixing-loop. The bottle does not touch the legs of the slit. An envelope for the device is also disclosed.

Abstract: The device comprises a sheet of paper or card, having a slit formed therein. The slit makes an inverted U-shape, having left and right leg portions, and a cross-bar. The slit divides the sheet into a front panel, on which a greetings message can be written or printed, and a fixing-loop, which slips over the neck of the bottle. The vertical length of the legs of the slit is shorter than the width between the legs, whereby the device comes to rest on the bottle, with the neck of the bottle touching the inside of the front panel and the back of the fixing-loop. The bottle does not touch the legs of the slit. An envelope for the device is also disclosed.