Patents by Inventor Linda C. Shackelford

Linda C. Shackelford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and apparatus for genetic regulation by electromagnetic stimulation fields
    Patent number: 10724030
    Abstract: The present invention provides a system for delivering a time-varying stimulation field to a subject. In the system, a power source, a control component and a transmission component operate as a stimulation field generator to provide a predetermined time-varying stimulation field to up-regulate or down-regulate an expression level of human genes. The present invention also provides a wearable apparatus for delivering the time-varying magnetic field to mammalian cells associated with bone formation in a subject. The wearable apparatus contains the stimulation field generator in a housing. The resulted modification on gene regulation of these genes and mammalian cells promotes the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: July 28, 2020
    Assignee: United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • System and Apparatus for Genetic Regulation by Electromagnetic Stimulation Fields
    Publication number: 20180171327
    Abstract: The present invention provides a system for delivering a time-varying stimulation field to a subject. In the system, a power source, a control component and a transmission component operate as a stimulation field generator to provide a predetermined time-varying stimulation field to up-regulate or down-regulate an expression level of human genes. The present invention also provides a wearable apparatus for delivering the time-varying magnetic field to mammalian cells associated with bone formation in a subject. The wearable apparatus contains the stimulation field generator in a housing. The resulted modification on gene regulation of these genes and mammalian cells promotes the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Application
    Filed: February 19, 2018
    Publication date: June 21, 2018
    Applicant: United States of America as Represented by the Administrator of the National Aeronautics and Spac
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Genetic regulation of bone and cells by electromagnetic stimulation fields and uses thereof
    Patent number: 9896681
    Abstract: The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the B-Field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles. Examples of mammalian cells or tissues are chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination. The resulted modification on gene regulation of these cells, tissues or bones may promote the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: February 20, 2018
    Assignee: The United States of America as represented by the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Genetic Regulation of Bone and Cells by Electromagnetic Stimulation Fields and Uses thereof
    Publication number: 20140342428
    Abstract: The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the B-Field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles. Examples of mammalian cells or tissues are chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination. The resulted modification on gene regulation of these cells, tissues or bones may promote the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 20, 2014
    Applicant: USA as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Modifying the genetic regulation of bone and cartilage cells and associated tissue by EMF stimulation fields and uses thereof
    Patent number: 8795147
    Abstract: An apparatus and method to modify the genetic regulation of mammalian tissue, bone, or any combination.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: August 5, 2014
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford