Abstract: Disclosed is a topical method for providing highly effective analgesic, anti-inflammatory, antimicrobial and tissue-regenerating activities for the hitherto most effective prophylaxis and treatment of aphthous ulcers and herpes simplex lesions and for the effective treatment of burns and other oral mucosal lesions as well as for prophylaxis and treatment of gingivitis, periodontitis and tooth mobility comprising topically administering to the affected tissue an effective amount of a composition comprised of one or more safe and efficacious polyvalent metal compounds such as magnesium sulfate and aluminum potassium sulfate alone or preferably with one or more safe and efficacious anti-inflammatory compounds, such as a novel ultra-low-strength (0.02%) hydrocortisone acetate, that potentiate the activities of polyvalent metal compounds.

Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).

Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).