Patents by Inventor Linda D. B. McBroom

Linda D. B. McBroom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical proteomics
    Publication number: 20030166007
    Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).
    Type: Application
    Filed: February 3, 2003
    Publication date: September 4, 2003
    Applicant: MDS Proteomics Inc.
    Inventors: Shane Climie, Leroi Victor Desouza, Henry Duewel, Christopher Mark Hosfield, Linda Chiou-Lin Liao, Linda D. B. McBroom, Irving Sucholeiki, Leticia M. Toledo-Sherman
  • Chemical proteomics
    Publication number: 20030157575
    Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).
    Type: Application
    Filed: January 28, 2003
    Publication date: August 21, 2003
    Inventors: Shane Climie, Leroi Victor DeSouza, Henry S. Duewel, Christopher Mark Hosfield, Linda Chiou-Lin Liao, Linda D. B. McBroom, Irving Sucholeiki, Leticia M. Toledo-Sherman