Patents by Inventor Linda D. Siracusa

Linda D. Siracusa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fibrillin 1 gene comprising duplication mutation and compositions and kits using the same
    Patent number: 6010694
    Abstract: Human fibroblast cells that comprise a gene construct that comprises a duplication mutated fibrillin 1 gene operably linked to functional regulatory elements and compositions comprising such cells are disclosed. Methods of treating wounds and kits for practicing such methods are disclosed. Transgenic animals comprising a duplication mutated fibrillin 1 gene operably linked to a tissue specific and/or inducible promoter are disclosed. Methods of identifying individuals with a duplication mutated fibrillin 1 gene are disclosed. The methods comprises detecting a duplication of exons 17-40 of a fibrillin 1 gene or a gene product produced by expression of a duplication mutated fibrillin 1 gene. Methods of preventing expression of a duplication mutated fibrillin 1 gene are disclosed.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: January 4, 2000
    Assignee: Thomas Jefferson University
    Inventors: Linda D. Siracusa, Sergio A. Jimenez