Patents by Inventor Linda Dwoskin

Linda Dwoskin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vesicular Monoamine Transporter-2 Ligands and Their Use in the Treatment of Psychostimulant Abuse
    Publication number: 20170304227
    Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 26, 2017
    Inventors: Linda DWOSKIN, Peter Anthony CROOKS, Guangrong ZHENG, Justin R. NICKELL, Zheng CAO, Na-Ra LEE
  • Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors
    Patent number: 9649301
    Abstract: Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: May 16, 2017
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda Dwoskin, Guangrong Zheng, Sangeetha Sumithran, David Allen, Zhenfa Zhang, Paul Lockman
  • Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors
    Publication number: 20150352088
    Abstract: Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Application
    Filed: August 18, 2015
    Publication date: December 10, 2015
    Inventors: Peter Crooks, Linda Dwoskin, Guangrong Zheng, Sangeetha Sumithran, David Allen, Zhenfa Zhang, Paul Lockman
  • -Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors
    Patent number: 8940774
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and/or gastrointestinal tract disorders.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: January 27, 2015
    Inventors: Peter Crooks, Linda Dwoskin, Roger Papke, Guangrong Zheng, Sangeetha Sumithran
  • Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors
    Publication number: 20140080866
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and/or gastrointestinal tract disorders.
    Type: Application
    Filed: November 26, 2013
    Publication date: March 20, 2014
    Applicant: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda DWOSKIN, Roger Papke, Guangrong ZHENG, Sangeetha SUMITHRAN
  • Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors
    Publication number: 20140080859
    Abstract: Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Davis Allen, Zhenfa Zheng, Paul Lockman
  • Tris-quarternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 8299253
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and or gastrointestinal tract disorders.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: October 30, 2012
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda Dwoskin, Roger Papke, Guangrong Zheng, Sangeetha P Sumithran
  • NORNICOTINE FOR THE TREATMENT OF PAIN
    Publication number: 20100216847
    Abstract: This invention relates to the use of R(+)-, S(?)- or racemic nornicotine for the treatment of pain.
    Type: Application
    Filed: November 16, 2007
    Publication date: August 26, 2010
    Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joseph R. Holtman, JR., Peter A. Crooks, Linda Dwoskin, Elzbieta P. Wala
  • 2,6-disubstituted piperidines and piperazine compounds
    Patent number: 7368443
    Abstract: The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: which are used to treat diseases of the central nervous system, drug abuse, and withdrawal therefrom as well as treating eating disorders.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: May 6, 2008
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda Dwoskin, Marlon D. Jones, Dennis Keith Miller, Seth Davin Norholm, Guangrong Zheng, Sairam Krishamurthy
  • Bis-pyridino containing compounds for the use in the treatment of CNS pathologies
    Publication number: 20050261334
    Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
    Type: Application
    Filed: January 3, 2005
    Publication date: November 24, 2005
    Inventors: Peter Crooks, Linda Dwoskin, Joshua Ayers, Vladimir Grinevich, Sangeetha Sumithran
  • 2,6-disubstituted piperidines and piperazine compounds
    Publication number: 20040266824
    Abstract: The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: 1
    Type: Application
    Filed: March 31, 2004
    Publication date: December 30, 2004
    Inventors: Peter A. Crooks, Linda Dwoskin, Marlon D. Jones, Dennis Keith Miller, Seth Davin Norholm, Guangrong Zheng, Sairam Krishamurthy
  • 2,6-disubstituted piperidines as modulators of nicotinic acetylcholine receptor mediated neurotransmitter release, uptake and storage
    Patent number: 6703406
    Abstract: Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology having the following formulas:
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: March 9, 2004
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda Dwoskin, Dennis Keith Miller, Vladimir P. Grinevich, Seth Davin Norrholm, Guangrong Zheng
  • 2, 6-DISUBSTITUTED PIPERIDINES AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR MEDIATED NEUROTRANSMITTER RELEASE, UPTAKE AND STORAGE
    Publication number: 20040019081
    Abstract: Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology having the following formulas: 1
    Type: Application
    Filed: June 7, 2002
    Publication date: January 29, 2004
    Inventors: Peter A. Crooks, Linda Dwoskin, Dennis Keith Miller, Vladimir P. Grinevich, Seth Davin Norrholm, Guangrong Zheng