Patents by Inventor Linda Griffith
Linda Griffith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115143Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.Type: ApplicationFiled: December 20, 2023Publication date: April 11, 2024Inventors: Johannes Anton Thüring, Arthur Uber, III, David Griffiths, Michael McDermott, Charles Lang, Linda Van Roosmalen, Barry Skirble, Adam Czibur, Daniel Moore, Vincenzo Caruso, Brandon Clarke
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Patent number: 11732229Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.Type: GrantFiled: November 20, 2020Date of Patent: August 22, 2023Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Linda Griffith, David Trumper, Collin Edington, Gaurav Rohatgi, Duncan Freake, Luis Soenksen, Brij Mohan Bhushan
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Publication number: 20220105510Abstract: Materials and methods of making have been developed for mass production of thermoplastic microfluidic chips. An elastomer diaphragm with a stress relieving feature can be used in microfluidic valves, pump diaphragms, and diaphragm micropumps. An optimized pump chamber design for complete fluid displacement and chamber geometry are provided. Microfluidic pressure regulators use a pneumatically actuated elastic membrane in a back-pressure regulator configuration. Microfluidic accumulators store pressurized fluid in a microfluidic chip. Removable caps for cell culture and a quick release top are described. Methods to incorporate hydrogels and ECM scaffolds have been developed. Electro pneumatic manifolds connect and control of multiple microfluidic devices vertically or on a rotary mechanism.Type: ApplicationFiled: October 6, 2021Publication date: April 7, 2022Inventors: Duncan A. O'Boyle, Linda Griffith, David Trumper
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Patent number: 11113669Abstract: In various embodiments, tools and user interfaces are provided that cater to the way that many employees desire to view their human resources data and human resources related transactions. These tools can be configured to provide appropriate, distilled contextual information, and transparency to the employment situation of the employee.Type: GrantFiled: December 13, 2011Date of Patent: September 7, 2021Assignee: The PNC Financial Services Group, Inc.Inventors: Helen Anne Miles, Linda Griffith, Scott Paterson, Zhen Zeng, Jen M. Levin, Elizabeth A. Spenko
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Publication number: 20210139829Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.Type: ApplicationFiled: November 20, 2020Publication date: May 13, 2021Inventors: Linda Griffith, David Trumper, Collin Edington, Gaurav Rohatgi, Duncan Freake, Luis Soenksen, Brij Mohan Bhushan
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Patent number: 10913925Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: GrantFiled: November 23, 2016Date of Patent: February 9, 2021Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of TechnologyInventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Patent number: 10876088Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.Type: GrantFiled: February 6, 2017Date of Patent: December 29, 2020Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Linda Griffith, David Trumper, Collin Edington, Gaurav Rohatgi, Duncan Freake, Luis Soenksen, Mohan Brij Bhushan
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Publication number: 20200292944Abstract: Customizable hydrogel patterned into arrays of microwells, microchannels, or other microfeatures, and a process to prepare patterned hydrogel adherent to a solid support, are provided. A pattern of light is applied to photopolymerizable hydrogel precursor solution on a solid support, resulting in the formation of a patterned hydrogel bonded to the solid support. Hydrogel precursor solution is held by a ring of a customized height secured to a photomask or to a surface allowing transmission of a pattern of light. This process allows for facile customization and repeated fabrications of hydrogel microwells of desired heights and geometries with a micron or submicron scale resolution, adherent on various solid supports.Type: ApplicationFiled: November 17, 2016Publication date: September 17, 2020Inventors: Marianna Sofman, Natasha Arora, Linda Griffith, Paula Hammond
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Patent number: 10733570Abstract: In various embodiments, tools and user interfaces are provided that cater to the way that many employees desire to view their human resources data and human resources related transactions. These tools can be configured to provide appropriate, distilled contextual information, and transparency to the employment situation of the employee.Type: GrantFiled: December 13, 2011Date of Patent: August 4, 2020Assignee: The PNC Financial Services Group, Inc.Inventors: Helen Anne Miles, Linda Griffith, Scott Paterson, Zhen Zeng, Jen M. Levin, Elizabeth A. Spenko
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Publication number: 20170227525Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.Type: ApplicationFiled: February 6, 2017Publication date: August 10, 2017Inventors: Linda Griffith, David Trumper, Collin Edington, Gaurav Rohatgi, Duncan Freake, Luis Soenksen, Mohan Brij Bhushan
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Publication number: 20170137768Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: ApplicationFiled: November 23, 2016Publication date: May 18, 2017Inventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Patent number: 9528082Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: GrantFiled: July 25, 2013Date of Patent: December 27, 2016Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of TechnologyInventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Patent number: 9098831Abstract: In various embodiments, tools and user interfaces are provided that cater to the way that many employees desire to view their human resources data and human resources related transactions. These tools can be configured to provide appropriate, distilled contextual information, and transparency to the employment situation of the employee.Type: GrantFiled: December 13, 2011Date of Patent: August 4, 2015Assignee: The PNC Financial Services Group, Inc.Inventors: Helen Anne Miles, Linda Griffith, Scott Paterson, Zhen Zeng, Jen M. Levin, Elizabeth A. Spenko
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Publication number: 20140030752Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.Type: ApplicationFiled: July 25, 2013Publication date: January 30, 2014Inventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
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Publication number: 20070087364Abstract: The present invention is directed to novel assays to measure the genotoxic effects of compounds on erythroid cells in vitro.Type: ApplicationFiled: September 27, 2006Publication date: April 19, 2007Applicant: Massachusetts Institute of TechnologyInventors: Joe Shuga, Linda Griffith, Harvey Lodish, Leona Samson, Dharini Shah, Jing Zhang
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Publication number: 20050260179Abstract: A method for capturing stem cells and/or progenitor cells from circulating body fluids such as blood or lymph in vivo and enabling the cells to colonize a specific, localized site for purposes of tissue regeneration or repair, has been developed. The method consists of selecting a site in need of repair or regeneration. Materials which can be used to provide the growth factors or ligands include polymeric matrices having the growth factor or ligands attached thereto, materials releasing growth factor or ligands (such as hydrogels, polymers, fibrin clots), and cells which release or have bound to their surfaces the growth factors or ligands.Type: ApplicationFiled: November 6, 2002Publication date: November 24, 2005Applicants: The General Hospital Corporation D/B/A Massachusetts General Hospital, Massachusetts Institute of TechnologyInventors: Mark Fishman, Linda Griffith, Paul Huang
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Publication number: 20050260745Abstract: A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.Type: ApplicationFiled: May 19, 2005Publication date: November 24, 2005Inventors: Karel Domansky, Linda Griffith, Steven Tannenbaum, Alan Wells
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Patent number: 6730298Abstract: Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occurring tissue. This method can be used for a variety of reconstructive procedures, including custom molding of cell implants to reconstruct three dimensional tissue defects, as well as implantation of tissues generally.Type: GrantFiled: January 20, 1998Date of Patent: May 4, 2004Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Linda Griffith-Cima, Anthony Atala, Charles A. Vacanti, Keith T. Paige
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Publication number: 20010055588Abstract: Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occurring tissue. This method can be used for a variety of reconstructive procedures, including custom molding of cell implants to reconstruct three dimensional tissue defects, as well as implantation of tissues generally.Type: ApplicationFiled: August 9, 2001Publication date: December 27, 2001Inventors: Linda Griffith-Cima, Anthony Atala, Charles A. Vacanti, Keith T. Paige
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Patent number: 5709854Abstract: A cell-polymeric solution is injected into an animal where the polymer crosslinks to form a polymeric hydrogel containing dispersed cells and the cells form new tissue in the animal. The polymer is biodegradable and is a natural polymer such as alginate or a synthetic polymer. The cells are chondrocytes, osteoblasts, muscle cells, fibroblasts or cells acting primarily to synthesize, secret or metabolize materials. Crosslinking of the polymer results from using cations or anions, altering the pH or changing the temperature. A polyion such as polyethyleneimine or polylysine can be added before injection to stabilize the polymeric hydrogel. A kit for tissue formation is provided by combining the cell-polymeric solution with a means for injecting the solution into an animal.Type: GrantFiled: April 30, 1993Date of Patent: January 20, 1998Assignee: Massachusetts Institute of TechnologyInventors: Linda Griffith-Cima, Anthony Atala, Charles A. Vacanti, Keith T. Paige