Patents by Inventor Linda J. Van Eldik

Linda J. Van Eldik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Myosin light chain kinase inhibitor compounds, compositions and related methods of use
    Patent number: 8791116
    Abstract: Pyridazinyl compounds, compositions and related methods of use.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 29, 2014
    Assignee: Northwestern University
    Inventors: Daniel Martin Watterson, Linda J. Van Eldik, Heather Behanna, Hantamalala Ralay Ranaivo
  • Pyridazine compounds, compositions and methods
    Patent number: 8367672
    Abstract: The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: February 5, 2013
    Assignees: Universite de Strasbourg, Northwestern University, Centre National de la Recherche Scientifique (CNRS)
    Inventors: D. Martin Watterson, Linda J. Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
  • MYOSIN LIGHT CHAIN KINASE INHIBITOR COMPOUNDS, COMPOSITIONS AND RELATED METHODS OF USE
    Publication number: 20130029999
    Abstract: Pyridazinyl compounds, compositions and related methods of use.
    Type: Application
    Filed: October 1, 2012
    Publication date: January 31, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: DANIEL MARTIN WATTERSON, LINDA J. VAN ELDIK, HEATHER BEHANNA, HANTAMALALA RALAY RANAIVO
  • Myosin light chain kinase inhibitor compounds, compositions and related methods of use
    Patent number: 8278305
    Abstract: Pyridazinyl compounds, compositions and related methods of use.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: October 2, 2012
    Assignee: Northwestern University
    Inventors: Daniel Martin Watterson, Linda J. Van Eldik, Heather Behanna, Hantamalala Ralay Ranaivo
  • Protein kinase targeted therapeutics
    Patent number: 8188096
    Abstract: The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1?, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1?, and upstream and downstream protein kinases).
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: May 29, 2012
    Assignee: Northwestern University
    Inventors: D. Martin Watterson, Linda J. Van Eldik
  • Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
    Patent number: 8088774
    Abstract: A novel class of pyridazine compositions and related methods of use.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: January 3, 2012
    Assignees: Northwestern University, Universite de Strasbourg, Centre National de la Recherche Scientifique, A Scientific Research Centre
    Inventors: Daniel Martin Watterson, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon
  • Protein Kinase Targeted Therapeutics
    Publication number: 20110166153
    Abstract: The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1?, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1?, and upstream and downstream protein kinases).
    Type: Application
    Filed: February 24, 2011
    Publication date: July 7, 2011
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: D. Martin Watterson, Linda J. Van Eldik
  • Protein kinase targeted therapeutics
    Patent number: 7919485
    Abstract: The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1?, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1?, and upstream and downstream protein kinases).
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: April 5, 2011
    Assignee: Northwestern University
    Inventors: D. Martin Watterson, Linda J. Van Eldik
  • Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
    Patent number: 7888357
    Abstract: A novel class of pyridazine compositions and related methods of use.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: February 15, 2011
    Assignees: Northwestern University, Universite de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Daniel Martin Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert
  • Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death
    Publication number: 20100317665
    Abstract: A novel class of pyridazine compositions and related methods of use.
    Type: Application
    Filed: July 7, 2010
    Publication date: December 16, 2010
    Inventors: D.M. Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Halech, Jean-Jacques Bourguignon, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert
  • COMPOSITIONS AND TREATMENTS FOR SEIZURE-RELATED DISORDERS
    Publication number: 20100210590
    Abstract: The present invention relates to therapeutic and/or prophylactic uses of pyridazine compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disorder characterized by conduction disturbances, electroconvulsions and/or seizures, in particular epilepsy, more particularly pediatric epilepsy. In an aspect of the invention, the pyridnsine compound has the Formula (Ia) or (Ib) wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the description.
    Type: Application
    Filed: February 29, 2008
    Publication date: August 19, 2010
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Martin D. Watterson, Linda J. Van Eldik, Mark S. Wainwright
  • Myosin light chain kinase inhibitor compounds, compostions and related methods of use
    Patent number: 7732445
    Abstract: Pyridazinyl compounds, compositions and related methods of use.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: June 8, 2010
    Assignee: Northwestern University
    Inventors: D. Martin Watterson, Linda J. Van Eldik, Heather Behanna, Hantamalala Ralay Ranaivo
  • Protein Kinase Targeted Therapeutics
    Publication number: 20100016587
    Abstract: The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1?, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1?, and upstream and downstream protein kinases).
    Type: Application
    Filed: September 24, 2009
    Publication date: January 21, 2010
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: D. Martin Watterson, Linda J. Van Eldik
  • Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
    Publication number: 20030176437
    Abstract: A novel class of pyridazine compositions and related methods of use.
    Type: Application
    Filed: September 3, 2002
    Publication date: September 18, 2003
    Inventors: D.M. Watterson, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon
  • Synthetic peptides and use thereof in preparing calmodulin antisera
    Patent number: 4716150
    Abstract: The compounds of the present invention are synthetic peptides useful in developing antisera against vertebrate or plant calmodulins. The peptides have chain lengths of from 8 to 15 amino acids arranged in linear N-terminal to C-terminal sequences which include either the amino acid segment asparagine-tyrosine-glutamic acid-glutamic acid-phenylalanine-valine-glutamine, corresponding to a minimal immunoreactive site of vertebrate calmodulin, or the segment asparagine-tyrosine-glutamic acid-glutamic acid-phenylalanine-valine-lysine, corresponding to the analogous amino acid regin of plant calmodulin.
    Type: Grant
    Filed: August 26, 1985
    Date of Patent: December 29, 1987
    Assignees: Vanderbilt University, The Rockefeller University
    Inventors: Linda J. Van Eldik, D. Martin Watterson