Patents by Inventor Linda Johanna Aleida Hendriks

Linda Johanna Aleida Hendriks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivalent antibody
    Patent number: 11952424
    Abstract: The invention relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein the base antibody portion is connected by a linker to the at least one additional binding domain, wherein each binding domain of the base antibody portion and each of the at least one additional binding domains all have a common variable region, and wherein the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, linking a variable region of the base antibody portion and the CH1 region, and wherein the multivalent antibody binds to at least three different epitopes.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: April 9, 2024
    Assignee: merus n.v.
    Inventors: Cornelis Adriaan de Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • Methods and means for the production of Ig-like molecules
    Patent number: 11926859
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: May 16, 2023
    Date of Patent: March 12, 2024
    Assignee: Merus N.V.
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • ANTIBODY COMPOSITION
    Publication number: 20240058444
    Abstract: The present invention relates to a (bio)pharmaceutical composition, particularly a liquid (e.g. aqueous) biopharmaceutical composition, more particularly a liquid biopharmaceutical composition comprising an anti-EGFR/anti-LGR5 bispecific antibody. The present invention also relates inter alia to a method of manufacturing the composition, to a kit including the composition, to a package including the composition, to a method of manufacturing the package, and to methods of treatment using the composition and/or package, especially cancer treatments, for example, for the treatment of colorectal cancer.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 22, 2024
    Inventors: Alexander Berthold Hendrik BAKKER, Linda Johanna Aleida HENDRIKS, Robert Paul DOORNBOS, Tudor ARVINTE, Guillaume Desire DARPIN, Emilie Brigitte POIRIER
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20230340556
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: May 16, 2023
    Publication date: October 26, 2023
    Inventors: Cornelis Adriaan DE KRUIF, Linda Johanna Aleida HENDRIKS, Ton LOGTENBERG
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20210071222
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: July 21, 2020
    Publication date: March 11, 2021
    Inventors: Cornelis Adriaan DE KRUIF, Linda Johanna Aleida HENDRIKS, Ton LOGTENBERG
  • Methods and means for the production of ig-like molecules
    Patent number: 10752929
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: August 25, 2020
    Assignee: Merus N.V.
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20200017897
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: May 20, 2019
    Publication date: January 16, 2020
    Inventors: Cornelis Adriaan DE KRUIF, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • MULTIVALENT ANTIBODY
    Publication number: 20190352401
    Abstract: The invention relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein the base antibody portion is connected by a linker to the at least one additional binding domain, wherein each binding domain of the base antibody portion and each of the at least one additional binding domains all have a common variable region, and wherein the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, linking a variable region of the base antibody portion and the CH1 region, and wherein the multivalent antibody binds to at least three different epitopes.
    Type: Application
    Filed: March 29, 2019
    Publication date: November 21, 2019
    Inventors: Cornelis Adriaan de Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • Methods and means for the production of Ig-like molecules
    Patent number: 10337045
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: July 2, 2019
    Assignee: Merus N.V.
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • Methods and means for the production of Ig-like molecules
    Patent number: 10329596
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 25, 2019
    Assignee: Merus N.V.
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20170369923
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: May 16, 2016
    Publication date: December 28, 2017
    Inventors: Cornelis Adriaan DE KRUIF, Linda Johanna Aleida HENDRIKS, Ton LOGTENBERG
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20170327860
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: April 25, 2017
    Publication date: November 16, 2017
    Inventors: Cornelis Adriaan DE KRUIF, Linda Johanna Aleida HENDRIKS, Ton LOGTENBERG
  • Methods and means for the production of Ig-like molecules
    Patent number: 9758805
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: September 12, 2017
    Assignee: Merus N.V.
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20160177364
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Inventors: Cornelis Adriaan DE KRUIF, Linda Johanna Aleida HENDRIKS, Ton LOGTENBERG
  • Methods and means for the production of IG-like molecules
    Patent number: 9358286
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: June 7, 2016
    Assignee: Merus B.V.
    Inventors: Cornelis A. De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • Methods and means for the production of Ig-like molecules
    Patent number: 9248182
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: February 2, 2016
    Assignee: Merus B.V.
    Inventors: Cornelis A. De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • Methods and means for the production of Ig-like molecules
    Patent number: 9248181
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: February 2, 2016
    Assignee: Merus B.V.
    Inventors: Cornelis A. De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20150196637
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: April 19, 2013
    Publication date: July 16, 2015
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20150139996
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: April 19, 2013
    Publication date: May 21, 2015
    Inventors: Cornelis Adriaan De Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
  • METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
    Publication number: 20140140999
    Abstract: The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 22, 2014
    Applicant: MERUS B.V.
    Inventors: Cornelis A. DE KRUIF, Linda Johanna Aleida HENDRIKS, Ton LOGTENBERG