Patents by Inventor Linda Klei

Linda Klei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULES AND THEIR USE AS MALT1 INHIBITORS
    Publication number: 20240124410
    Abstract: Small molecule inhibitors that block the interaction between B-cell lymphoma 10 protein (BCL10) and mucosa- associated lymphoid tissue lymphoma translocation protein 1 (MALT1), thereby inhibiting both the protease and scaffolding activities of MALT1, and MALT1- dependent downstream signaling, including IL-6 and IL-10 secretion by B-cell lymphoma cells and IL-2 transcription and secretion by Jurkat T cells.
    Type: Application
    Filed: March 24, 2022
    Publication date: April 18, 2024
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Regents of the University of Michigan
    Inventors: Peter C. Lucas, Linda M. McAllister, Heejae Kang, Beibei Chen, Lisa Maurer, Dong Hu, Jing Cheng, Linda Klei, Zaneta Nikolovska-Coleska