Patents by Inventor Linda M. McAllister

Linda M. McAllister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULES AND THEIR USE AS MALT1 INHIBITORS
    Publication number: 20240124410
    Abstract: Small molecule inhibitors that block the interaction between B-cell lymphoma 10 protein (BCL10) and mucosa- associated lymphoid tissue lymphoma translocation protein 1 (MALT1), thereby inhibiting both the protease and scaffolding activities of MALT1, and MALT1- dependent downstream signaling, including IL-6 and IL-10 secretion by B-cell lymphoma cells and IL-2 transcription and secretion by Jurkat T cells.
    Type: Application
    Filed: March 24, 2022
    Publication date: April 18, 2024
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Regents of the University of Michigan
    Inventors: Peter C. Lucas, Linda M. McAllister, Heejae Kang, Beibei Chen, Lisa Maurer, Dong Hu, Jing Cheng, Linda Klei, Zaneta Nikolovska-Coleska
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Publication number: 20030054992
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Application
    Filed: April 3, 2002
    Publication date: March 20, 2003
    Applicant: ICOS Corporation
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Patent number: 6037119
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 14, 2000
    Assignee: Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Antibodies to cGMP-binding, cGMP-specific phospodiesterase
    Patent number: 5955583
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 21, 1999
    Assignees: ICOS Corporation, Board of Regents of the University of Washington, Vanderbilt University
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Patent number: 5702936
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: December 30, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Patent number: 5652131
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 29, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas