Abstract: A medical dressing for application to a surface of a human body is described. The medical dressing has a first direction (x) of extension and a second direction (y) of extension being perpendicular to the first direction (x) of extension. The medical dressing has at least a first and a second anisotropic layer having anisotropic stiffness, wherein the stiffness of each one of the first and the second anisotropic layer is higher in the second direction (y) of extension than in the first direction (x) of extension.

Abstract: A medical dressing for prevention of pressure ulcers is described. The dressing has a backing layer, a pad, and a body contact layer, wherein the pad is arranged between the backing layer and the body contact layer. The body contact layer has an adhesive skin contact layer and an anisotropic layer having a first (x) direction and a second (y) direction perpendicular to the first (x) direction. The anisotropic layer is stiffer in the second (y) direction than in the first (x) direction. The dressing reduces shear and compression forces on the skin and in the underlying soft tissue layers and prevents the onset of pressure ulcers.

Abstract: A medical dressing for application to a surface of a human body is described. The medical dressing has a first direction (x) of extension and a second direction (y) of extension being perpendicular to the first direction (x) of extension. The medical dressing has at least a first and a second anisotropic layer having anisotropic stiffness, wherein the stiffness of each one of the first and the second anisotropic layer is higher in the second direction (y) of extension than in the first direction (x) of extension.

Abstract: A topical dermal delivery device, such as a patch, for topical delivery of nitric oxide (NO) to treatment sites of mammals is disclosed. In an embodiment the patch has three layers; a backing with an activation window, a absorbent core as a reservoir and an NO permeable membrane with an adhesive layer towards the skin. The NO donor is applied into the device as a solution prior to application through the activation window. The window is closed after activation and the lid and backing is non-permeable for NO in order to increase the partial pressure of NO and thus the concentration of dissolved NO. The patch is fixated on the area to be treated with an adhesive layer that also assures sufficient contact throughout the treatment. The generated NO moves within the patch and can escape through the NO permeable membrane towards the area to be treated. Depending on therapy needed, the patch release curve differs and is chosen accordingly.

Abstract: A topical dermal delivery device, such as a patch, for topical delivery of nitric oxide (NO) to treatment sites of mammals is disclosed.