Patents by Inventor Linda N. Casillas

Linda N. Casillas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20150094333
    Abstract: Disclosed are compounds having the formula: wherein R1, R2R3, R4 and R5 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: September 13, 2013
    Publication date: April 2, 2015
    Inventors: Linda N. Casillas, Michael P. Demartino, Pamela A. Haile, John F. Mehlmann, Joshi M. Ramanjulu, Robert Singhaus, JR.
  • Calcilytic compounds
    Patent number: 8980950
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 17, 2015
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • PRODRUGS OF AMINO QUINAZOLINE KINASE INHIBITOR
    Publication number: 20150045323
    Abstract: Disclosed are compounds having the formula: wherein X is as defined herein, and methods of making and using the same.
    Type: Application
    Filed: September 13, 2013
    Publication date: February 12, 2015
    Inventors: Linda N. Casillas, Pamela A. Haile, Robert W. Marquis, JR., Gren Wang
  • QUINOLYL AMINES AS KINASE INHIBITORS
    Publication number: 20140256949
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: May 21, 2014
    Publication date: September 11, 2014
    Applicant: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Linda N. CASILLAS, Adam Kenneth Charnley, Pamela A. Haile, Terry Vincent Hughes, Robert W. Marquis, JR., John F. Mehlmann, Michael Reilly, Joseph J. Romano, Robert R. Singhaus, JR.
  • AMINO QUINAZOLINES AS KINASE INHIBITORS
    Publication number: 20140206688
    Abstract: Disclosed are compounds having the formula (Formula I)): wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: August 17, 2012
    Publication date: July 24, 2014
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam K. Charnley, Michael P. Demartino, Xiaoyang Dong, Patrick M. Eidam, Pamela A. Haile, Robert W. Marquis, JR., Joshi M. Ramanjulu, Joseph J. Romano, Ami Lakdawala Shah, Robert R. Singhaus, JR., Gren Wang
  • CALCILYTIC COMPOUNDS
    Publication number: 20140057980
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Applicant: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20130345258
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 26, 2013
    Applicant: Glaxosmithline LLC
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Pamela A. Haile, Robert W. Marquis, JR., John F. Mehlmann, Joseph J. Romano, Robert R. Singhaus, JR., Gren Z. Wang
  • Calcilytic compounds
    Patent number: 8586631
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: November 19, 2013
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Calcilytic compounds
    Patent number: 8399517
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: March 19, 2013
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20130053375
    Abstract: Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: May 6, 2011
    Publication date: February 28, 2013
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Michael P. DeMartino, Xiaoyang Dong, Patrick Eidam, Pamela A. Haile, Philip Anthony Harris, Ami Lakdawala Shah, Bryan W. King, Robert W. Marquis, JR., John F. Mehlmann, Joseph J. Romano, Clark A. Sehon
  • PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20130023534
    Abstract: Disclosed are compounds having the formula (I): wherein Z, n, R1, R1A, R3, R4, and R5 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 26, 2011
    Publication date: January 24, 2013
    Inventors: Linda N. Casillas, Subhas J. Chakravorty, Patrick Eidam, Pamela A. Haile, Terry Vincent Hughes, Ami Lakdawala Shah, Lara Kathryn Leister, Nathan Andrew Miller, Attiq Rahman, Clark A. Sehon, Gren Z. Wang, Daohua Zhang
  • INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20130023532
    Abstract: Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 26, 2011
    Publication date: January 24, 2013
    Inventors: Linda N. Casillas, Subhas J. Chakravorty, Adam Kenneth Charnley, Pamela A. Haile, Terry Vincent Hughes, Jae U. Jeong, Jianxing Kang, Ami Lakdawala Shah, Lara Kathryn Leister, Robert W. Marquis, JR., Nathan Andrew Miller, Daniel J. Price, Clark A. Sehon, Gren Z. Wang, Daohua Zhang, Patrick Eidam
  • IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
    Publication number: 20130018039
    Abstract: Disclosed are compounds having the formula: wherein R1A, R1B, R2 and R3 are defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 31, 2011
    Publication date: January 17, 2013
    Inventors: Vera Q. Bodmer, Linda N. Casillas, Michael P. DeMartino, Philip A. Harris, Bryan W. King, Ami Lakdawala Shah, Lara Kathryn Leister, Joshi M. Ramanjulu, Joseph J. Romano, Gren Z. Wang, Matthew A. Wilson, David Duff Wisnoski
  • Calcilytic Compounds
    Publication number: 20110054021
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 3, 2011
    Inventors: ROBERT W. MARQUIS, LINDA N. CASILLAS, JOSHI M. RAMANJULU, JAMES FRANCIS CALLAHAN
  • Calcilytic compounds
    Patent number: 7829594
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: November 9, 2010
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Calcilytic Compounds
    Publication number: 20090163589
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: February 26, 2009
    Publication date: June 25, 2009
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Calcilytic compounds
    Patent number: 7514473
    Abstract: Novel Calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham, Corp.
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Novel Compounds
    Publication number: 20090012011
    Abstract: This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted pyrrolidines, according to Formula I Specifically, the invention is directed to compounds according to Formula I wherein R1 is H or C1-C6 alkyl; R2 is H or OH; and R3 is an optionally substituted aryl.
    Type: Application
    Filed: January 11, 2007
    Publication date: January 8, 2009
    Applicant: SmithKline Beecham Corporation
    Inventors: Linda N. Casillas, Robert W. Marquis, JR.
  • Novel Compounds
    Publication number: 20080318945
    Abstract: This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted piperazines, according to Formula I A compound of formula I wherein Z is bond or NH; R1 is aryl or optionally substituted heteroaryl; R2 is H, optionally substituted C1-6alkyl, or optionally substituted C2-6alkenyl; R3 and R7 are independently H, optionally substituted C1-6alkyl, or aryl; R4 is H or optionally substituted C1-6alkyl; R5 is H or C1-6alkyl; R6 is H or C1-6alkyl; and X and X? are independently O or H2; or wherein R3 and R4 together form a part of morpholinyl, piperadinyl, or aziridinyl ring; and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 15, 2006
    Publication date: December 25, 2008
    Inventors: Linda N. Casillas, Robert W. Marquis, JR.