Abstract: The disclosure relates to materials and methods for the in vitro testing of irritants. It was discovered that the accuracy of nonanimal toxicity tests is improved when the distance migrated on a synthetic substrate is used as a correction factor for macromolecular, cell, and specific organotypic eye toxicity test systems. The method involves applying the test substance to a solid support test material, measuring the migration distance and then using the migration distance measurement to improve on an existing nonanimal toxicity test; where the existing toxicity test prediction can be: (1) a macromolecular test, (2) a cultured epithelium-based (3) and/or an organotypic test; measuring a test system response; and multiplying, adding, or otherwise using as a correction factor, the measured migration distance, and using this to have an improved prediction of the toxicity of the test substance based on the combined response.

Abstract: Disclosed are formulations and procedures to improve the accuracy of nonanimal tests. Disclosed procedures involve both the direct application of the substance to be tested to the excised eye or other suitable test matrix, such as a differentiated tissue, and the application of an aqueous layer to the apical surface and then the addition of the substance to be tested as an overlay to the aqueous layer for a period of time so as to allow metabolism of the substance to be tested by the eye or test matrix, but not so long as to result in nonirritant or nontoxic test substance resulting in a FP result.

Abstract: A system according to an embodiment optimizes communications with users using machine learning based models. The system receives user profile data for a set of users. For each user from the set of users, the system provides the user profile data as input to a machine learning based model and determines attributes describing the user, for example a measure of adherence rate for the user. The system ranks the set of users based on the predicted attributes. The system selects a subset of users from the set of users based on the ranking. For each selected user from the set of selected users, the system determines communication parameters for communicating with the selected user and sends a communication to the selected user based on the determined communication parameters.

Abstract: Systems and methods for collaborative illumination estimation for mobile mixed-reality devices are provided. Embodiments described herein compose an illumination estimate using video data capturing an environment which includes a reflective object, such as a light probe. Radiance samples are computed from light reflections from the reflective object, which are then interpolated to compose a realistic estimation of physical lighting of the environment. Robust illumination estimation is provided in a computationally efficient manner, supplying real-time updates to facilitate integration with augmented reality (AR) systems and other image processing applications. The computational efficiency of this approach allows for implementation in lower-resource environments, such as mobile devices. In some examples, multiple devices can collaborate to capture the environment from different viewpoints and enhance realism and fidelity in their illumination estimates.

Abstract: An electrical device includes at least one cross-linked layer obtained from a polymer composition that has: at least one polymer comprising one or more epoxy function(s), and at least one cross-linking agent. The cross-linking agent is selected from: a non-aromatic cyclic amine, an imidazole of formula (I) where R1 and R2 independently represent a hydrogen atom or a hydrocarbon group, R3 and R4 independently represent a hydrogen atom or a hydrocarbon group, or R3 and R4 form, together with the carbon atoms of the imidazole ring to which they are attached, a ring, with the imidazole being associated with a cross-linking co-agent having at least one reactive function capable of reacting with the epoxy function of said polymer, and, a mixture thereof.

Abstract: Systems and methods for collaborative illumination estimation for mobile mixed-reality devices are provided. Embodiments described herein compose an illumination estimate using video data capturing an environment which includes a reflective object, such as a light probe. Radiance samples are computed from light reflections from the reflective object, which are then interpolated to compose a realistic estimation of physical lighting of the environment. Robust illumination estimation is provided in a computationally efficient manner, supplying real-time updates to facilitate integration with augmented reality (AR) systems and other image processing applications. The computational efficiency of this approach allows for implementation in lower-resource environments, such as mobile devices. In some examples, multiple devices can collaborate to capture the environment from different viewpoints and enhance realism and fidelity in their illumination estimates.

Abstract: The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample.

Abstract: The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample.

Abstract: The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample.

Abstract: The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample.

Abstract: A method for updating an application on a mobile device includes accessing, at the mobile device, application management information. The application management information identifies a plurality of applications installed on the mobile device and one or more granted permission settings associated with each installed application. The method also includes sending, from the mobile device to a server, a request for update information regarding each installed application and receiving, at the mobile device from the server, the update information. The update information identifies an update package for a respective application of the plurality of installed applications. The method also includes installing the update package without user interaction from a user of the mobile device if one or more required permission settings associated with the update package are included in the one or more granted permission settings associated with the respective application of the plurality of installed applications.

Abstract: Systems and methods for multi-dimensional aggregation. Exemplary embodiments include a method for retrieving data from an inverted list index within a computer system, wherein the index comprises annotated postings, the method including receiving a query in a system, converting the query into a query language, scanning at least one list of postings for data from the query, aggregating the data in the list, thereby resulting in an aggregated list, wherein the aggregating includes recording the occurrence of unique values from the list, mapping the values using a user-provided definition to an alternate value, grouping the values by a user-provided mapping of values to groups, recording and mutating data associated with the unique value in the list, relating the recorded data values with other values in the index and returning the requested data from the aggregated list in a return format.

Abstract: Systems and methods for multidimensional aggregation. Exemplary embodiments include a method for retrieving data from an inverted list index within a computer system, wherein the index comprises annotated postings, the method including receiving a query in a system, converting the query into a query language, scanning at least one list of postings for data from the query, aggregating the data in the list, thereby resulting in an aggregated list, wherein the aggregating includes recording the occurrence of unique values from the list, mapping the values using a user-provided definition to an alternate value, grouping the values by a user-provided mapping of values to groups, recording and mutating data associated with the unique value in the list, relating the recorded data values with other values in the index and returning the requested data from the aggregated list in a return format.

Abstract: Systems and methods for multi-dimensional aggregation. Exemplary embodiments include a method for retrieving data from an inverted list index within a computer system, wherein the index comprises annotated postings, the method including receiving a query in a system, converting the query into a query language, scanning at least one list of postings for data from the query, aggregating the data in the list, thereby resulting in an aggregated list, wherein the aggregating includes recording the occurrence of unique values from the list, mapping the values using a user-provided definition to an alternate value, grouping the values by a user-provided mapping of values to groups, recording and mutating data associated with the unique value in the list, relating the recorded data values with other values in the index and returning the requested data from the aggregated list in a return format.

Abstract: A system and method for prioritizing a fetch order of web pages. The method comprises extracting by a web crawler a set of candidate web pages to be crawled. Each web page in the set of candidate web pages is associated with a website in a computer network. A determination is made to determine if a first website score for the website is in a website score database. The first website score is associated with web pages in the set of candidate web pages if the first website score exists in the website score database. The set of candidate web pages is prioritized with respect to an associated website score for each web page in the candidate set of web pages. Content is retrieved from the set of candidate web. Hyperlinks are extracted from the content. The hyperlinks are stored in a memory unit.