Patents by Inventor Linda Nicholson

Linda Nicholson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALZHEIMER'S DISEASE THERAPEUTICS BASED ON PIN-1 CATALYZED CONFORMATIONAL CHANGES IN PHOSPHORYLATED AMYLOID PRECURSOR PROTEIN
    Publication number: 20080058276
    Abstract: The present invention is directed to inhibiting amyloidogenic processing of amyloid precursor protein, and/or inhibiting production of amyloid beta peptides. These methods can involve accelerating cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or contacting a cell with a compound that mimics the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein. The present invention also relates to treating and/or preventing in a subject a degenerative neurological disease characterized by amyloidogenic processing of amyloid precursor protein and/or overproduction of amyloid beta peptide. This method involves administering an agent that accelerates cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or inhibits production of amyloid ? peptides.
    Type: Application
    Filed: January 16, 2007
    Publication date: March 6, 2008
    Applicants: CORNELL RESEARCH FOUNDATION, INC., BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Kun LU, Linda NICHOLSON, Lucia PASTORINO, Xiao ZHOU, Soumya DE
  • Collectible race car cookie jar
    Patent number: D349632
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: August 16, 1994
    Inventors: Linda Nicholson, Clarence Russell