Patents by Inventor Linda Nolan Keyes

Linda Nolan Keyes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRBs as Modifiers of Branching Morphogenesis and Methods of Use
    Publication number: 20080163386
    Abstract: Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.
    Type: Application
    Filed: January 28, 2007
    Publication date: July 3, 2008
    Applicant: EXELIXIS, INC.
    Inventors: Felix D. Karim, Linda Nolan Keyes, Gregory D. Plowman, Michael Martin Ollmann, Mark E. Maxwell, Thierry Tidiane Diagana
  • MAP4Ks as modifiers of branching morphogenesis and methods of use
    Publication number: 20030113782
    Abstract: Human MAP4K genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP4K are provided.
    Type: Application
    Filed: November 25, 2002
    Publication date: June 19, 2003
    Inventors: Felix D. Karim, Linda Nolan Keyes, Gregory D. Plowman
  • CRBs as modifiers of branching morphogenesis and methods of use
    Publication number: 20030100005
    Abstract: Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.
    Type: Application
    Filed: November 25, 2002
    Publication date: May 29, 2003
    Inventors: Felix D. Karim, Linda Nolan Keyes, Gregory D. Plowman, Michael Martin Ollmann, Mark E. Maxwell, Thierry Tidiane Diagana
  • Nucleic acids and proteins of D. melanogaster insulin-like genes and uses thereof
    Patent number: 6468770
    Abstract: The present invention relates to D. melangaster insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of D. melangaster insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a D. melangaster insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a D.
    Type: Grant
    Filed: November 30, 1998
    Date of Patent: October 22, 2002
    Assignee: Exelixis Pharmaceuticals, Inc.
    Inventors: Linda Nolan Keyes, Stephen Kohl Doberstein, Andrew Roy Buchman, Bindu Priya Reddy, David Andrew Ruddy