Patents by Inventor Linda O'Brien

Linda O'Brien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
    Patent number: 6090280
    Abstract: A method and apparatus for high-throughput identity confirmation, quantitation and purity determination of a compound of interest in a mixture of compounds is disclosed. According to the method, a chemical mixture, such as may be obtained from a chemical library, is processed to obtain a stream having a time-varying composition, such as by using a high pressure liquid chromatograph. The stream is split into two portions or streams for substantially contemporaneous detection in a compound-identifying device, such as a mass spectrograph, and in a compound-quantitating device, such as an evaporative light scattering detector. A peak in a chromatogram obtained from the compound-quantitating device is identified as the compound of interest by cross-correlation, via elution time, with chromatographic results obtained from the compound-identifying device. Once the peak is identified as corresponding to the compound of interest, the corresponding peak area is used for quantitation and purity determination.
    Type: Grant
    Filed: April 19, 1999
    Date of Patent: July 18, 2000
    Assignee: Pharmacopeia, Inc.
    Inventors: James A. Connelly, Linda O'Brien, Sue Xiuqing Zhang, Ning Zhao
  • High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
    Patent number: 5938932
    Abstract: A method and apparatus for high-throughput identity confirmation, quantitation and purity determination of a compound of interest in a mixture of compounds is disclosed. According to the method, a chemical mixture, such as may be obtained from a chemical library, is processed to obtain a stream having a time-varying composition, such as by using a high pressure liquid chromatograph. The stream is split into two portions or streams for substantially contemporaneous detection in a compound-identifying device, such as a mass spectrograph, and in a compound-quantitating device, such as an evaporative light scattering detector. A peak in a chromatogram obtained from the compound-quantitating device is identified as the compound of interest by cross-correlation, via elution time, with chromatographic results obtained from the compound-identifying device. Once the peak is identified as corresponding to the compound of interest, the corresponding peak area is used for quantitation and purity determination.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: August 17, 1999
    Assignee: Pharmacopeia, Inc.
    Inventors: James A. Connelly, Linda O'Brien, Sue Xiuqing Zhang, Ning Zhao