Patents by Inventor Linda P. Dwoskin

Linda P. Dwoskin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vesicular Monoamine Transporter-2 Ligands and Their Use in the Treatment of Psychostimulant Abuse
    Publication number: 20220315523
    Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse/addiction and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
    Type: Application
    Filed: June 16, 2022
    Publication date: October 6, 2022
    Inventors: Linda P. DWOSKIN, David WATT, Jon THORSON, Mark LEGGAS, Rodney Kip GUY, Jared HAMMILL, Stefan KWIATKOWSKI, Derong DING, Guangrong ZHENG, Peter Anthony CROOKS, Na-Ra LEE
  • Vesicular Monoamine Transporter-2 Ligands and Their Use in the Treatment of Psychostimulant Abuse
    Publication number: 20200290948
    Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
    Type: Application
    Filed: April 14, 2020
    Publication date: September 17, 2020
    Inventors: Linda P. DWOSKIN, David WATT, Jon THORSON, Mark LEGGAS, Kip GUY, Jared HAMMILL, Stefan KWIATKOWSKI, Derong DING, Guangrong ZHENG, Peter Anthony CROOKS, Na-Ra LEE
  • VESICULAR MONOAMINE TRANSPORTER-2 LIGANDS AND THEIR USE IN THE TREATMENT OF PSYCHOSTIMULANT ABUSE
    Publication number: 20200237688
    Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
    Type: Application
    Filed: April 13, 2020
    Publication date: July 30, 2020
    Inventors: Linda P. DWOSKIN, Peter Anthony CROOKS, Guangrong ZHENG, Justin R. NICKELL, Zheng CAO, Na-Ra LEE
  • Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
    Patent number: 10668030
    Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: June 2, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Linda P. Dwoskin, Peter Anthony Crooks, Guangrong Zheng, Justin R. Nickell, Zheng Cao, Na-Ra Lee
  • Method of treating neuropathic pain
    Patent number: 10071982
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: September 11, 2018
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R Holtman, Peter Anthony Crooks, Linda P Dwoskin, J Michael McIntosh, Elzbieta Pogonowska Wala
  • 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds
    Publication number: 20170226072
    Abstract: The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.
    Type: Application
    Filed: April 24, 2017
    Publication date: August 10, 2017
    Inventors: Peter A. CROOKS, Linda P. DWOSKIN, John CULVER, Justin R. NICKELL, Guangrong ZHENG
  • Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 9550753
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: January 24, 2017
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Zhenfa Zhang
  • Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 9540327
    Abstract: Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: January 10, 2017
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran
  • METHOD OF TREATING NEUROPATHIC PAIN
    Publication number: 20160340335
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 6, 2013
    Publication date: November 24, 2016
    Applicants: University of Utah, University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter Anthony CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH, Elzbieta Pogonowska WALA
  • Bis-quaternary ammonium salts as pain modulating agents
    Patent number: 9499518
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: November 22, 2016
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R. Holtman, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
    Publication number: 20160279119
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 13, 2010
    Publication date: September 29, 2016
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds
    Publication number: 20160031840
    Abstract: The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Inventors: Peter A. CROOKS, Linda P. DWOSKIN, John CULVER, Justin R. NICKELL, Guangrong ZHENG
  • Use of -quaternary ammonium salts as pain modulating agents
    Patent number: 9155733
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nociception and pain.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: October 13, 2015
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R. Holtman, Peter Anthony Crooks, Linda P. Dwoskin, J. Michael McIntosh
  • Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors
    Publication number: 20140371266
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 18, 2014
    Inventors: Peter CROOKS, Linda P. DWOSKIN, Guangrong ZHENG, Sangeetha SUMITHRAN, Zhenfa ZHENG
  • Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 8846937
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: September 30, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Zhenfa Zheng
  • -quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 8703803
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and or gastrointestinal tract disorders.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: April 22, 2014
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Roger Papke, Guangrong Zheng, Sangeetha Sumithran
  • -quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors
    Patent number: 8653275
    Abstract: Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: February 18, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Davis D. Allen, Zhenfa Zheng, Paul Lockman
  • Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors
    Patent number: 8629163
    Abstract: Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: January 14, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Zhenfa Zhang, Marharyta Pivavarchyk
  • METHOD OF TREATING NEUROPATHIC PAIN
    Publication number: 20140011836
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 9, 2014
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter Anthony CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH, Elzbieta Pogonowska WALA
  • -pyridino containing compounds for the use in the treatment of CNS pathologies
    Patent number: 8546415
    Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: October 1, 2013
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Joshua Ayers, Vladimir Grinevich, Sangeetha Sumithran