Abstract: A method is provided for in vivo or ex vivo delivery of a preparation of powdered nucleic acid molecules into vertebrate tissue for transformation of cells in the tissue using needleless injection techniques. The method can be used to deliver therapeutically relevant nucleotide sequences to cells in mammalian tissue to provide gene therapy, elicit immunity or to provide antisense or ribozyme functions. A method for providing densified processed pharmaceutical compositions is also described. The method is used to convert non-dense pharmaceutical powders or particulate formulations into densified particles optimally suited for transdermal delivery using a needleless syringe. The method is also used to optimize the density and particle size of powders and particulate formulations for subsequent transdermal delivery thereof. Densified pharmaceutical compositions formed by the present methods are also provided.

Abstract: Built-in tests included in reset functions of single board computers can be rapidly performed to confirm adequate functionality without additional hardware support by disabling an error correcting code function in a memory controller, writing a pattern of predictable parity to a location in memory and reading and correcting the pattern with the error correcting code function of the memory controller re-enabled. Thus, resets caused by, for example, momentary soft errors or power interruptions can be executed within rigid time constraints and thus negligibly short interruptions of processor function.