Patents by Inventor Linda Sandell

Linda Sandell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of migration and induction of cell death by the type II collagen amino propeptides
    Patent number: 8435937
    Abstract: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an ?v?3 and/or an ?v?5 integrin.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: May 7, 2013
    Assignee: Washington University
    Inventors: Linda Sandell, Zhepeng Wang
  • Inhibition of migration and induction of cell death by the type II collagen amino propeptides
    Patent number: 8278266
    Abstract: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an ?v?3 and/or an ?v?5 integrin.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: October 2, 2012
    Assignee: Washington University
    Inventors: Linda Sandell, Zhepeng Wang
  • INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES
    Publication number: 20120196364
    Abstract: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an ?v?3 and/or an ?v?5 integrin.
    Type: Application
    Filed: April 9, 2012
    Publication date: August 2, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Linda Sandell, Zhepeng Wang
  • Inhibition of migration and induction of cell death by the type II collagen amino propeptides
    Patent number: 7851436
    Abstract: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an ?v?3 and/or an ?v?5 integrin.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: December 14, 2010
    Assignee: Washington University
    Inventors: Linda Sandell, Zhepeng Wang
  • INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES
    Publication number: 20100278724
    Abstract: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an ?v?3 and/or an ?v?5 integrin.
    Type: Application
    Filed: July 15, 2010
    Publication date: November 4, 2010
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Linda Sandell, Zhepeng Wang
  • INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES
    Publication number: 20080300168
    Abstract: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an ?v?3 and/or an ?v?5 integrin.
    Type: Application
    Filed: April 7, 2008
    Publication date: December 4, 2008
    Applicant: Washington University in St. Louis
    Inventors: Linda Sandell, Zhepeng Wang
  • Trimerizing Polypeptides and Their Uses
    Publication number: 20080166798
    Abstract: A method for trimerizing collagenous molecule monomers comprising the step of contacting a collagen domain and a non-collagenous trimerization domain is provided. In addition, methods of trimerizing heterologous peptides is provided. Trimerizing polypeptides, vectors, cells, and trimerized polypeptides are also provided.
    Type: Application
    Filed: August 21, 2004
    Publication date: July 10, 2008
    Applicant: Barnes-Jewish Hospital
    Inventors: Audrey McAlinden, Erika Crouch, Linda Sandell
  • UNCOUPLED COLLAGEN SYNTHESIS AND DEGRADATION ASSAYS
    Publication number: 20070292892
    Abstract: The invention relates to methods for determining the progression of cartilage degeneration diseases, such as osteoarthritis and rheumatoid arthritis, by quantitating collagen synthesis and degradation markers in patient samples. One can determine whether a cartilage degeneration condition is progressing, regressing, or remaining stable by quantitating collagen synthesis and degradation markers in patient samples and comparing the value obtained to a reference value. When a joint affected by cartilage degeneration in question expresses collagen synthesis and degradation markers, a change in this value is indicative of a change in the progression of the cartilage degeneration condition. The methods and apparatus of the invention allow accurate determination of the therapeutic effects certain cartilage degeneration drug treatments, including osteoarthritis and rheumatoid arthritis drug treatments, so are also useful for pharmaceutical efficacy studies in mammals.
    Type: Application
    Filed: June 5, 2007
    Publication date: December 20, 2007
    Inventors: Linda Sandell, Patrick Garnero