Abstract: Disclosed herein are intranasal immunogenic compositions comprising viral glycoprotein nanoparticles, which are suitable for use as vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed. Methods for using the intranasal immunogenic compositions to stimulate an immune response in a subject against a virus are also disclosed.

Abstract: A wheelchair configured to impart motion on one or more lower extremities of a user to inhibit inelasticity in joints of one or more lower extremities as a result of extended immobility, and to promote a more natural alignment of one or more upper extremities of the user during manipulation of the wheelchair. The wheelchair includes a seat and a backrest, at least two ground-engaging wheels, a hand mechanism assembly including a hand grip on each side of the wheelchair, and a foot mechanism assembly including a footrest on each of the wheelchair. When a force is applied to one of the hand grips, the wheels rotate for locomotion, and the foot mechanism assembly is actuated, causing the foot rest on the opposite side from the hand grip to move in an arced path, and vice versa, thereby imparting contralateral locomotion.

Abstract: The present disclosure relates to a drawing device for creating a pattern, wherein the drawing device comprises a gear assembly that rotates upon movement of the device, the gear assembly being operatively coupled to a cam and a cam follower, such that rotation of the gear assembly rotates the cam and causes the cam to bear against the cam follower. Movement of the cam follower thereby causes lateral movement of a marker carriage housing at least one writing instrument.

Abstract: The present disclosure relates to a drawing device for creating a pattern, wherein the drawing device comprises a gear assembly that rotates upon movement of the device, the gear assembly being operatively coupled to a cam and a cam follower, such that rotation of the gear assembly rotates the cam and causes the cam to bear against the cam follower. Movement of the cam follower thereby causes lateral movement of a marker carriage housing at least one writing instrument.

Abstract: A mobility device including one or more sensors configured to transmit user mobility data to an external electronic device such as a smartphone or a computer. In embodiments, the mobility device can be a cane, crutch, walker, wheelchair, walking stick, or walking pole. A system for measuring real time mobility data of a user is also disclosed.

Abstract: An ambulatory aid, such as one or more crutches, including a height adjustable shaft, a handle portion extending from a middle portion of the shaft, a foot portion, and an extension portion termination with a closed loop cuff for securing to the upper arm of a subject. The height adjustable shaft of the crutch can be adjustable at a top end, middle, a bottom end, or any combination thereof. The top of the cane shaft is aligned at a more posterior angle then the bottom of the shaft. The handle of the crutch is elongated and extends horizontally and lateral to the height adjustable shaft. In a particular embodiment, a posterior portion of the handle is longer, and optionally larger in surface area than an anterior portion of the handle such that the handle is configured so that when the person's hand is gripping the handle, the handle will be offset over the shaft.

Abstract: A wheelchair configured to impart motion on one or more lower extremities of a user to inhibit inelasticity in joints of one or more lower extremities as a result of extended immobility, and to promote a more natural alignment of one or more upper extremities of the user during manipulation of the wheelchair. The wheelchair includes a seat and a backrest, at least two ground-engaging wheels, a hand mechanism assembly including a hand grip on each side of the wheelchair, and a foot mechanism assembly including a footrest on each of the wheelchair. When a force is applied to one of the hand grips, the wheels rotate for locomotion, and the foot mechanism assembly is actuated, causing the foot rest on the opposite side from the hand grip to move in an arced path, and vice versa, thereby imparting contralateral locomotion.

Abstract: A three- or four-wheeled mobility walker/rollator including a foldable or collapsible frame assembly including a main or anterior frame assembly and a posterior frame assembly, three or four wheels coupled to the bottom or base of the frame assembly, and at least two crossbar handles coupled to the top of the frame assembly. The crossbar handles are placed one in front of the other with the first posterior crossbar handle being aligned with or slightly behind the middle of the back wheel posterior to the bottom of the walker frame. The crossbars can be of a sufficient width and curvature to provide a continuous support for the forearms when the user is standing, and can provide more frontal plane stability and balance during locomotion compared to the handles of a traditional walker.

Abstract: An ambulatory aid, such as a crutch, including a pair of support members connected by a load bearing handle member, and terminating at a first end with a top axilla-conforming member, and a second end with a foot piece. The crutch is used as a straight arm crutch, in which a user's weight is distributed in the hand to keep the arm straight, while preventing any load on the shoulder girdles. The crutches are configured to fit close to the body, to centralize the base of support, and keep the center of gravity lower, thereby keeping the body aligned as designed, and keeping the pectoral and pelvic girdles aligned. Proper body alignment during use results in greater stability and equilibrium of the user compared to traditional “tri-pod” creating crutches.

Abstract: An ambulatory aid, such as a walking cane, including an elongate shaft, a handle at a first, upper end of the shaft, and a foot piece at a second, lower end of the shaft opposite the first end. The cane shaft can be adjustable at a top end, middle, a bottom end, or any combination thereof. The top of the cane shaft is aligned at a more posterior angle then the bottom of the shaft. The handle of the cane is elongated and extends posterior and anterior to the shaft. In a particular embodiment, a posterior portion of the handle is longer, and optionally larger in surface area than an anterior portion of the handle such that the handle is configured so that when the person's hand is gripping the handle, the handle will be offset over the shaft.

Abstract: A system and method are provided for targeting marketing content to a user. A user's photographic likeness, in some embodiments as a still image, live moving image, or animated moving image, are altered to simulate the application of selected marketing content onto the photographic likeness. The marketing content is selected from a set of marketing content comprising input color, marketing content associated with an advertisement, or marketing content associated with a set of search results. The marketing content is selected based on a comparison of a user profile to target profiles of the set of marketing content.

Abstract: A three- or four-wheeled mobility walker/rollator including a foldable or collapsible frame assembly including a main or anterior frame assembly and a posterior frame assembly, three or four wheels coupled to the bottom or base of the frame assembly, and at least two crossbar handles coupled to the top of the frame assembly. The crossbar handles are placed one in front of the other with the first posterior crossbar handle being aligned with or slightly behind the middle of the back wheel posterior to the bottom of the walker frame. The crossbars can be of a sufficient width and curvature to provide a continuous support for the forearms when the user is standing, and can provide more frontal plane stability and balance during locomotion compared to the handles of a traditional walker.

Abstract: An ambulatory aid, such as a crutch, including a pair of support members connected by a load bearing handle member, and terminating at a first end with a top axilla-conforming member, and a second end with a foot piece. The crutch is used as a straight arm crutch, in which a user's weight is distributed in the hand to keep the arm straight, while preventing any load on the shoulder girdles. The crutches are configured to fit close to the body, to centralize the base of support, and keep the center of gravity lower, thereby keeping the body aligned as designed, and keeping the pectoral and pelvic girdles aligned. Proper body alignment during use results in greater stability and equilibrium of the user compared to traditional “tri-pod” creating crutches.

Abstract: High mobility group A1 (Hmga1) chromatin remodeling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. The present invention describes a method of producing a genetically modified organoid comprising the following steps: isolating a crypt of the small intestine; culturing a portion of the crypt in a culture medium; forming an organoid; and transducing the organoid with a vector comprising Hmga1. Methods using genetically modified organoids to treat or prevent injuries including cancer are described.

Abstract: An ambulatory aid, such as a walking cane, including an elongate shaft, a handle at a first, upper end of the shaft, and a foot piece at a second, lower end of the shaft opposite the first end. The cane shaft can be adjustable at a top end, middle, a bottom end, or any combination thereof. The top of the cane shaft is aligned at a more posterior angle then the bottom of the shaft. The handle of the cane is elongated and extends posterior and anterior to the shaft. In a particular embodiment, a posterior portion of the handle is longer, and optionally larger in surface area than an anterior portion of the handle such that the handle is configured so that when the person's hand is gripping the handle, the handle will be offset over the shaft.

Abstract: An ambulatory aid, such as a walking cane, including an elongate shaft, a handle at a first, upper end of the shaft, and a foot piece at a second, lower end of the shaft opposite the first end. The cane shaft can be adjustable at a top end, middle, a bottom end, or any combination thereof. The top of the cane shaft is aligned at a more posterior angle then the bottom of the shaft. The handle of the cane is elongated and extends posterior and anterior to the shaft. In a particular embodiment, a posterior portion of the handle is longer, and optionally larger in surface area than an anterior portion of the handle such that the handle is configured so that when the person's hand is gripping the handle, the handle will be offset over the shaft.

Abstract: Systems, methods, apparatuses, and computer readable medium are provided that cause a two dimensional image to appear three dimensional and also create a dynamic or animated illustrated images. The systems, methods, apparatuses and computer readable mediums implement displacement maps in a number of novel ways in conjunction with among other software, facial feature recognition software to recognize the areas of the face and allow the users to then customize those areas that are recognized. Furthermore, the created displacement maps are used to create all of the dynamic effects of an image in motion.

Abstract: Techniques are provided for a real-time virtual reflection and for video interaction with virtual objects in a system. According to one embodiment, a user's image is captured by a video camera, and is outputted to a visual display in reverse, providing a mirror-image feedback to the user's movements. Through the camera interface, the system interprets user's gestures to manipulate virtual objects in real-time, in conjunction with the user's movements. In some embodiments, a user simulates trying on apparel and accessories according to the techniques set forth.