Patents by Inventor Linda W. Roti Roti

Linda W. Roti Roti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5 -C]pyridazine-5'-phosphate as a novel compound and its utility against L-1210 mouse leukemia
    Patent number: 4123524
    Abstract: The compound 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c ]pyridazines-5'-phosphate (a nucleotide) as a new compound and its method of synthesis by phosphorylation of the known 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c ]pyridazine (a nucleoside). The 5'-phosphate ester has utility against L-1210 mouse leukemia and has superior solubility over the parent compound which gives it a broader use pattern relative to dosage. This novel nucleotide also shows advantage in utilization as to pH over, for example, the hydrochloride salt which gives in solution a pH of 4 and is too acid for use.
    Type: Grant
    Filed: June 8, 1977
    Date of Patent: October 31, 1978
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Leroy B. Townsend, Arthur F. Lewis, Linda W. Roti Roti