Patents by Inventor Linda Wyatt

Linda Wyatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant MVA viruses expressing clade A/G, clade B, and clade C modified HIV env, gag and pol genes
    Patent number: 9453239
    Abstract: The invention provides modified vaccinia Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: September 27, 2016
    Assignees: Emory University, The Government of the United States of America, as represented by the Secretary Department of Health and Human Services, National Institutes of Health
    Inventors: Bernard Moss, Linda Wyatt, Harriet L. Robinson
  • Modified vaccinia Ankara (MVA) virus recombinants comprising heterologous coding sequences inserted into the intergenic regions between essential genes
    Patent number: 9133478
    Abstract: The present invention relates to new insertion sites useful for the integration of exogenous sequences into an intergenic region (IGR) of a vaccinia virus genome, where the IGR is located between or is flanked by two adjacent open reading frames (ORFs) of the vaccinia virus genome, and where the ORFs correspond to conserved genes, and to related plasmid vectors useful to insert exogenous DNA into the genome of a vaccinia virus, and further to recombinant vaccinia viruses comprising an exogenous sequence inserted into said new insertion site as a medicine or vaccine.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: September 15, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Bernard Moss, Linda Wyatt, Patricia Earl
  • MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG AND POL GENES
    Publication number: 20150238593
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: December 10, 2014
    Publication date: August 27, 2015
    Applicants: EMORY UNIVERSITY, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID), UNITED STATES DEPARTMENT OF HEAL
    Inventors: BERNARD MOSS, LINDA WYATT, PATRICIA EARL, HARRIET L. ROBINSON
  • MVA expressing modified HIV envelope, gag, and pol genes
    Patent number: 8916172
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: December 23, 2014
    Assignees: Emory University, National Institute of Allergy and Infectious Diseases (NIAID), The United States of America, as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Linda Wyatt, Patricia Earl, Harriet L. Robinson
  • MVA expressing modified HIV envelope, GAG, and POL genes
    Publication number: 20110159036
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: October 19, 2007
    Publication date: June 30, 2011
    Inventors: Bernard Moss, Patricia L. Earl, Linda Wyatt, Leigh Anne Eller, Thomas C. VanCott, Matthew Edward Harris
  • MVA Expressing Modified HIV Envelope, GAG, and POL Genes
    Publication number: 20110104199
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 5, 2011
    Inventors: Bernard Moss, Linda Wyatt, Patricia Earl, Harriet L. Robinson
  • MVA expressing modified HIV envelope, gag, and pol genes
    Patent number: 7867982
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: January 11, 2011
    Assignee: Emory University
    Inventors: Bernard Moss, Linda Wyatt, Patricia Earl, Harriet L. Robinson
  • INTERGENIC SITES BETWEEN CONSERVED GENES IN THE GENOME OF MODIFIED VACCINIA ANKARA (MVA) VACCINIA VIRUS
    Publication number: 20100143402
    Abstract: The present invention relates to new insertion sites useful for the integration of exogenous sequences into an intergenic region (IGR) of a vaccinia virus genome, where the IGR is located between or is flanked by two adjacent open reading frames (ORFs) of the vaccinia virus genome, and where the ORFs correspond to conserved genes, and to related plasmid vectors useful to insert exogenous DNA into the genome of a vaccinia virus, and further to recombinant vaccinia viruses comprising an exogenous sequence inserted into said new insertion site as a medicine or vaccine.
    Type: Application
    Filed: August 24, 2007
    Publication date: June 10, 2010
    Inventors: Bernard Moss, Linda Wyatt, Patricia Earl
  • MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG, AND POL GENES
    Publication number: 20090074726
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: January 22, 2008
    Publication date: March 19, 2009
    Inventors: Bernard MOSS, Linda Wyatt, Patricia Earl, Harriet L. Robinson
  • Recombinant Mva Viruses Expressing Clade A/G, Clade B, and Clade C Modified Hiv Env Gag and Pol Genes
    Publication number: 20080193483
    Abstract: The invention provides modified vaccinia Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: August 29, 2005
    Publication date: August 14, 2008
    Inventors: Bernard Moss, Linda Wyatt, Harriet L. Robinson
  • MVA expressing modified HIV envelope, gag, and pol genes
    Patent number: 7303754
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: December 4, 2007
    Assignees: The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The United States of America, as represented by the Secretary, Department of the Army
    Inventors: Bernard Moss, Patricia L. Earl, Linda Wyatt, Leigh Anne Eller, Thomas C. VanCott, Matthew Edward Harris
  • Compositions and methods for generating an immune response
    Publication number: 20070048861
    Abstract: The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein.
    Type: Application
    Filed: January 17, 2006
    Publication date: March 1, 2007
    Inventors: Harriet Robinson, James Smith, Jian Hua, Bernard Moss, Rama Amara, Linda Wyatt, Patricia Earl, Ted Ross, Rick Bright, Salvatore Butera, Dennis Ellenberger, Thomas Folks
  • MVA expressing modified HIV envelope, Gag, and Pol genes
    Publication number: 20060134133
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: September 28, 2005
    Publication date: June 22, 2006
    Inventors: Bernard Moss, Patricia Earl, Linda Wyatt, Leigh Eller, Thomas VanCott, Matthew Harris
  • MVA expressing modified HIV envelope, gag, and pol genes
    Publication number: 20040146528
    Abstract: The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
    Type: Application
    Filed: August 22, 2003
    Publication date: July 29, 2004
    Inventors: Bernard Moss, Linda Wyatt, Patricia Earl, Harriet L. Robinson