Patents by Inventor Lindsay Hinck
Lindsay Hinck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200339676Abstract: Methods, agents, and compositions for promoting milk production in a mammal are provided. Agents useful for promoting milk production may include an agent that inhibits NOTCH4 activity. The agent may inhibit NOTCH4 activity by binding to ROBO2 and/or by binding to NOTCH4. The agent may inhibit NOTCH4 by competing with ROBO1 for binding to ROBO2, thereby making ROBO1 available to inhibit NOTCH4 activity. The agent may be a soluble ROBO1 extracellular domain or an anti-NOTCH4 antibody that inhibits NOTCH4 activity. The agent may be an RNAi construct that inhibits expression of NOTCH4 or an RNAi construct that inhibits expression of ROBO2. Also provided herein are transgenic mammals genetically modified for expression of a soluble ROBO1 extracellular domain; inhibition of expression of ROBO2; and/or inhibition of expression of NOTCH4. Methods for promoting milk production in such transgenic mammals by administering one or more of the agents disclosed herein are also provided.Type: ApplicationFiled: April 22, 2020Publication date: October 29, 2020Inventors: Lindsay Hinck, Sharmila Chatterjee, Oscar Cazares, Min Chen
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Patent number: 7919588Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: GrantFiled: May 1, 2008Date of Patent: April 5, 2011Assignee: The Regents of the University of CaliforniaInventors: Marc Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20080241857Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: May 1, 2008Publication date: October 2, 2008Applicant: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20060147988Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: March 7, 2006Publication date: July 6, 2006Applicant: The Regents of the University of CaliforniaInventors: Marc Tessier-Lavigne, E. Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 7041806Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: GrantFiled: September 27, 2002Date of Patent: May 9, 2006Assignee: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20030059859Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: September 27, 2002Publication date: March 27, 2003Inventors: Marc Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20030040046Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: August 20, 2001Publication date: February 27, 2003Inventors: Marc Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 6277585Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: GrantFiled: May 7, 1999Date of Patent: August 21, 2001Assignee: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 6087326Abstract: Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.Type: GrantFiled: January 15, 1998Date of Patent: July 11, 2000Assignee: The Regents of the University of CaliforniaInventors: Lindsay Hinck, Kasuko Masu, Masayuki Masu, David Leonardo, Marc Tessier-Lavigne
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Patent number: 5939271Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceuticai industry.Type: GrantFiled: February 19, 1997Date of Patent: August 17, 1999Assignee: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 5747262Abstract: Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.Type: GrantFiled: October 16, 1995Date of Patent: May 5, 1998Assignee: The Regents of the University of CaliforniaInventors: Lindsay Hinck, Kasuko Masu, Masayuki Masu, David Leonardo, Marc Tessier Lavigne