Patents by Inventor Lindsay N. Sanford

Lindsay N. Sanford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantum method for fluorescence background removal in DNA melting analysis
    Patent number: 11066696
    Abstract: A method of background removal from melting curves generated using a fluorescent dye is provided for analyzing a melting profile of a nucleic acid sample. The method comprises measuring the fluorescence of the nucleic acid sample as a function of temperature to produce a raw melting curve having a melting transition, the nucleic acid sample comprising a nucleic acid and a molecule that binds the nucleic acid to form a fluorescently detectable complex, the raw melting curve comprising a background fluorescence signal and a nucleic acid sample signal; and separating the background signal from the nucleic acid sample signal by use of a quantum algorithm to generate a corrected melting curve, the corrected melting curve comprising the nucleic acid sample signal.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Carl T. Wittwer, Lindsay N. Sanford
  • Monitoring temperature with fluorescence
    Patent number: 9850549
    Abstract: Systems, methods, and kits are provided wherein a temperature-sensitive reagent that emits a luminescent signal is used to adjust the identification of the temperature of a sample or to control thermocycling. In various illustrative embodiments, the sample is a PCR mixture.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: December 26, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Lindsay N. Sanford, Carl T. Wittwer
  • A QUANTUM METHOD FOR FLUORESCENCE BACKGROUND REMOVAL IN DNA MELTING ANALYSIS
    Publication number: 20160202195
    Abstract: A method of background removal from melting curves generated using a fluorescent dye is provided for analyzing a melting profile of a nucleic acid sample. The method comprises measuring the fluorescence of the nucleic acid sample as a function of temperature to produce a raw melting curve having a melting transition, the nucleic acid sample comprising a nucleic acid and a molecule that binds the nucleic acid to form a fluorescently detectable complex, the raw melting curve comprising a background fluorescence signal and a nucleic acid sample signal; and separating the background signal from the nucleic acid sample signal by use of a quantum algorithm to generate a corrected melting curve, the corrected melting curve comprising the nucleic acid sample signal.
    Type: Application
    Filed: August 29, 2014
    Publication date: July 14, 2016
    Inventors: Carl T. Wittwer, Lindsay N. Sanford
  • MONITORING TEMPERATURE WITH FLUORESCENCE
    Publication number: 20150247209
    Abstract: Systems, methods, and kits are provided wherein a temperature-sensitive reagent that emits a luminescent signal is used to adjust the identification of the temperature of a sample or to control thermocycling. In various illustrative embodiments, the sample is a PCR mixture.
    Type: Application
    Filed: October 8, 2013
    Publication date: September 3, 2015
    Inventors: Lindsay N. Sanford, Carl T. Wittwer