Abstract: The present invention relates generally to a method of amplifying closed circular nucleic acid probes and, more particularly, to a method of amplifying closed circular nucleic acid probes by rolling circle amplification. The method of the present invention is useful in a range of applications involving the detection of nucleic acid sequences such as, but not limited to, the identification of genetic disorders, genetic variants or the presence of microbiological or viral agents.

Abstract: The present invention relates generally to a method for identifying or otherwise detecting a nucleotide repeat region having a particular length in a nucleic acid molecule. Varying lengths of the repeat region at particular genetic locations represent nucleotide length polymorphisms. The present invention provides, therefore, a method for identifying a nucleotide length polymorphism such as associated with a particular human individual or animal or mammalian subject or for a disease condition or a predisposition for a disease condition to develop in a particular individual or subject. The method of the present invention is also useful for identifying and/or typing micro-organisms including yeasts and lower uni- and multi-cellular organisms as well as prokaryotic micro-organisms. The method of the present invention is further useful in genotyping subjects including humans.