Patents by Inventor Lindsey J. Bowman

Lindsey J. Bowman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure of the farnesoid X receptor ligand binding domain and methods of use therefor
    Patent number: 8212006
    Abstract: The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a time-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: July 3, 2012
    Assignee: The Salk Institute for Biological Studies
    Inventors: Michael R. Downes, Mark A. Verdicia, Joseph P. Noel, Ronald M. Evans, Lindsey J. Bowman, Marianne Bowman
  • STRUCTURE OF THE FARNESOID X RECEPTOR LIGAND BINDING DOMAIN AND METHODS OF USE THEREFOR
    Publication number: 20110018866
    Abstract: The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a time-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR.
    Type: Application
    Filed: January 12, 2010
    Publication date: January 27, 2011
    Inventors: Michael R. Downes, Mark A. Verdicia, Joseph P. Noel, Ronald M. Evans, Lindsey J. Bowman, Marianne Bowman
  • Structure of the farnesoid X receptor ligand binding domain and methods of use therefor
    Patent number: 7647217
    Abstract: The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist, fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a three-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: January 12, 2010
    Assignee: The Salk Institute for Biological Studies
    Inventors: Michael R Downes, Mark A. Verdicia, Joseph P. Noel, Ronald M. Evans, Lindsey J. Bowman, Marianne Bowman