Abstract: This invention discloses a method for comprehensively apportioning the source contribution to fine particular matter (PM2.5) based on the receptor model and the chemical transport model, which comprises the receptor model calculation steps, chemical transport model calculation steps and comprehensive source apportionment steps; the said comprehensive source apportionment step comprises the following sub-steps: according to the principle of inverse proportionality between uncertainty and weight coefficient, the first (receptor model) uncertainty and the second (chemical transport model) uncertainty are normalized to obtain their respective weight coefficients; the comprehensive source apportionment results are calculated based on the apportionment results of the receptor model and the chemical transport model, and their respective weight coefficient.