Patents by Inventor LING CAI
LING CAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12269885Abstract: The present invention provides an anti-PD-L1/VEGF bispecific antibody and a use thereof. Specifically, the present invention provides a bifunctional antibody, comprising: (a) anti-PD-L1 antibody or element; and (b) an anti-VEGF antibody or element linked to the anti-PD-L1 antibody or element. The bifunctional antibody of the present invention can simultaneously bind to VEGF and PD-L1, thereby exerting a therapeutic effect on VEGF and PD-L1-positive tumor cells (especially malignant tumor cells).Type: GrantFiled: March 31, 2020Date of Patent: April 8, 2025Assignee: HUABO BIOPHARM (SHANGHAI) CO., LTD.Inventors: Xiangyang Zhu, Fengxue Zhang, Mingqing Cai, Lei Zhang, Shi Chen, Ling Yu
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Publication number: 20240368022Abstract: A glass composition includes from 50 mol % to 80 mol % SiO2; from 5 mol % to 15 mol % Al2O3; from 10 mol % to 25 mol % B2O3; greater than or equal to 0 mol % Li2O; greater than or equal to 0 mol % Na2O; greater than or equal to 0 mol % K2O; greater than or equal to 0 mol % Rb2O; greater than or equal to 0 mol % Cs2O; from 1.5 mol % to 5 mol % MgO; from 4 mol % to 12 mol % CaO; and from 0.5 mol % to 5 mol % SrO. R2O is from 0.1 mol % to 15 mol %, R2O being the sum of Li2O, Na2O, K2O, Rb2O, and Cs2O.Type: ApplicationFiled: August 16, 2022Publication date: November 7, 2024Inventors: Venkatesh Botu, Ling Cai, Jesse Kohl, Mark Owen Weller
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Publication number: 20240300853Abstract: A glass-ceramic substrate includes a continuous glass phase; a magnetizable component; and an antimicrobial component. The substrate can further include a discontinuous glass phase disposed in the continuous glass phase. The magnetizable component and the antimicrobial component can be disposed in the discontinuous glass phase. The substrate can include 45 percent to 60 percent SiO2; 3 percent to 6 percent P2O5; 3 percent to 10 percent B2O3; 4 percent to 8 percent K2O; 7 percent to 15 percent Fe2O3; and 15 percent to 25 percent CuO. A ratio of the mole percentage of CuO to Fe2O3 in the substrate can be 1.3 to 3.0. The magnetizable component can include one or more of delafossite and magnetite. The antimicrobial component can include one or more of cuprite and metallic copper. The substrate can exhibit a magnetic permeability of greater than or equal to 1.02?R at a frequency of 10,000,000 Hz.Type: ApplicationFiled: January 4, 2022Publication date: September 12, 2024Inventors: David Eugene Baker, Bavani Balakrisnan, Ling Cai, Timothy Michael Gross
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Patent number: 12036728Abstract: The present invention relates to a paper-based 3D printing device and a printing method. The paper-based 3D printing device comprises a printing platform, a three-axis linkage platform, a cutting head and an inkjet head. The printing platform is used for placing paper, and the three-axis linkage platform is arranged to, firstly, drive the cutting head to cut the corresponding paper along the contour of a preset model to form a cutting seam, and then drive the inkjet head to inkjet color toward the cutting seam along the contour of the preset model. The paper-based 3D printing device and the printing method save ink, and can directly spray the ink at the cutting seam, which is equivalent to coloring the outer surface of the model, effectively improving the coloring effect, making the coloring of the outer surface of the model uniform, eliminating the step of printing one by one.Type: GrantFiled: August 17, 2020Date of Patent: July 16, 2024Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGYInventors: Guangxue Chen, Ling Cai, Linyi Chen, Qifeng Chen, Jiangping Yuan, Xiaochun Wang
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Patent number: 12017947Abstract: A glass-ceramic includes SiO2 in a range of 40 mol. % to 80 mol. %; Al2O3 in a range of 5 mol. % to 20 mol. %; MgO in a range of 5 mol. % to 20 mol. %; and at least one of B2O3, ZnO, and TiO2, each in a range of 0 mol. % to 10 mol. %, such that the glass-ceramic further comprises a magnesium aluminosilicate crystalline phase at a concentration in a range of 5 wt. % to 80 wt. % of the glass-ceramic.Type: GrantFiled: April 20, 2022Date of Patent: June 25, 2024Assignee: CORNING INCORPORATEDInventors: George Halsey Beall, Heather Debra Boek, Ling Cai, Mark Owen Weller
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Patent number: 11952310Abstract: Disclosed herein are glass compositions that present several advantages over glasses and other materials currently used for redistribution layers for RF, interposers, and similar applications. The glasses disclosed herein are low cost, flat glasses that have high throughput for the laser damage and etching process used to create through glass vias (TGV). TGV generated using the silicate glasses and processes described herein have large waist diameters (Dw), which is a desirable feature with respect to producing glass articles such as interposers.Type: GrantFiled: April 30, 2020Date of Patent: April 9, 2024Assignee: Corning IncorporatedInventors: Ling Cai, Tian Huang, Yuhui Jin, Jingshi Wu
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Publication number: 20230337543Abstract: Embodiments of a sensor are disclosed herein. The sensor includes a ceramic substrate having a first major surface, a second major surface opposite to the first major surface, and a thickness measured from the first major surface to the second major surface. The thickness is from 10 ?m to 200 ?m. A piezoelectric layer is disposed on the first major surface of the ceramic substrate, and the piezoelectric layer has a thickness of 10 ?m or less. At least one electrical contact is disposed on the piezoelectric layer or between the ceramic substrate and the piezoelectric layer or both on the piezoelectric layer and between the ceramic substrate and the piezoelectric layer. A wearable device including such a sensor is also disclosed herein as well as a method of manufacturing same.Type: ApplicationFiled: April 19, 2023Publication date: October 19, 2023Inventors: Ling Cai, JaeMyung Chang, Yang Liu, Jungwon Seo, Cheng-Gang Zhuang
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Patent number: 11695310Abstract: A motor, a cooling device, and a cooling method are disclosed. The cooling device is mounted on a stator of the motor. The cooling device includes a sleeve and a spiral duct. A wall of the sleeve has a spiral groove extending along the sleeve. The sleeve is sleeved onto the stator. The spiral duct is mounted in the spiral groove. The spiral duct has a first spiral form corresponding to the spiral groove, so that the spiral duct is correspondingly installed in the spiral groove. The spiral duct has a second spiral form extending along the spiral duct. A twisted spiral cooling channel is formed along the spiral pathway. A cooling fluid flowing through the twisted spiral cooling channel is subjected to the continuously changing cross-section of the twisted spiral cooling channel to enhance the swirl intensity, thereby improving the convection heat transfer effectiveness.Type: GrantFiled: November 30, 2020Date of Patent: July 4, 2023Assignee: National Cheng Kung UniversityInventors: Mi-Ching Tsai, Shyy-Woei Chang, Min-Fu Hsieh, Kai-Jung Shih, Wei-Ling Cai, Jen-Hsiang Liu
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Patent number: 11629090Abstract: An article including a glass having that includes SiO2, Al2O3, and B2O3 and least one of Li2O, Na2O, K2O, MgO, CaO, SrO, BaO, SnO2, ZnO, La2O3, F, and Fe2O3, wherein the glass includes a dielectric constant of about 10 or less and/or a loss tangent of about 0.01 or less, both as measured with signals at 10 GHz.Type: GrantFiled: August 18, 2021Date of Patent: April 18, 2023Assignee: Corning IncorporatedInventors: Heather Debra Boek, Ling Cai, Jennifer Anella Heine, Lisa Ann Lamberson, Adama Tandia, Kochuparambil Deenamma Vargheese, Mark Owen Weller
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Patent number: 11581778Abstract: A motor and a rotating shaft cooling device thereof are disclosed. A rotating shaft of the motor is formed with an annular space. A shaft has a front end and a rear end. The shaft is a blind tube formed with a channel communicating with the annular space through a plurality of nozzles. The distance between the nozzles and the rear end is less than one-half of the length of the shaft. A cooling fluid flows through the nozzles to form a jet array to impinge on the inner wall of the rotating shaft to cool the rotating shaft, and flows back in the annular space to enhance the cooling effect, increase the heat exchange area, and improve the cooling effectiveness of the rotating shaft.Type: GrantFiled: January 12, 2021Date of Patent: February 14, 2023Assignee: National Cheng Kung UniversityInventors: Mi-Ching Tsai, Shyy-Woei Chang, Min-Fu Hsieh, Kai-Jung Shih, Wei-Ling Cai, Bi-Sheng Wei
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Publication number: 20220242779Abstract: A glass-ceramic includes SiO2 in a range of 40 mol. % to 80 mol. %; Al2O3 in a range of 5 mol. % to 20 mol. %; MgO in a range of 5 mol. % to 20 mol. %; and at least one of B2O3, ZnO, and TiO2, each in a range of 0 mol. % to 10 mol. %, such that the glass-ceramic further comprises a magnesium aluminosilicate crystalline phase at a concentration in a range of 5 wt. % to 80 wt. % of the glass-ceramic.Type: ApplicationFiled: April 20, 2022Publication date: August 4, 2022Inventors: George Halsey Beall, Heather Debra Boek, Ling Cai, Mark Owen Weller
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Publication number: 20220224188Abstract: A motor and a rotating shaft cooling device thereof are disclosed. A rotating shaft of the motor is formed with an annular space. A shaft has a front end and a rear end. The shaft is a blind tube formed with a channel communicating with the annular space through a plurality of nozzles. The distance between the nozzles and the rear end is less than one-half of the length of the shaft. A cooling fluid flows through the nozzles to form a jet array to impinge on the inner wall of the rotating shaft to cool the rotating shaft, and flows back in the annular space to enhance the cooling effect, increase the heat exchange area, and improve the cooling effectiveness of the rotating shaft.Type: ApplicationFiled: January 12, 2021Publication date: July 14, 2022Inventors: MI-CHING TSAI, SHYY-WOEI CHANG, MIN-FU HSIEH, KAI-JUNG SHIH, WEI-LING CAI, BI-SHENG WEI
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Patent number: 11332405Abstract: A glass-ceramic includes SiO2 in a range of 40 mol. % to 80 mol. %; Al2O3 in a range of 5 mol. % to 20 mol. %; MgO in a range of 5 mol. % to 20 mol. %; and at least one of B2O3, ZnO, and TiO2, each in a range of 0 mol. % to 10 mol. %, such that the glass-ceramic further comprises a magnesium aluminosilicate crystalline phase at a concentration in a range of 5 wt. % to 80 wt. % of the glass-ceramic.Type: GrantFiled: July 9, 2019Date of Patent: May 17, 2022Assignee: CORNING INCORPORATEDInventors: George Halsey Beall, Heather Debra Boek, Ling Cai, Mark Owen Weller
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Patent number: 11258419Abstract: Embodiments of a filter for electromagnetic radiation are disclosed herein. The filter includes a first glass-ceramic substrate having a first refractive index, a second glass-ceramic substrate having the first refractive index, and a first region disposed between the first glass-ceramic substrate and the second glass-ceramic substrate. The first region has a second refractive index that is less than the first refractive index. Further, the second glass-ceramic substrate is arranged substantially parallel to and spatially disposed from the first glass-ceramic substrate. The filter transmits at least 70% of electromagnetic radiation within a band of frequencies and reflects at least 80% of electromagnetic radiation outside the band of frequencies. The band of frequencies is located within the frequency range of 20 GHz to 100 GHz.Type: GrantFiled: September 17, 2020Date of Patent: February 22, 2022Assignee: Corning IncorporatedInventors: George Halsey Beall, Nicholas Francis Borrelli, Ling Cai, Karl William Koch, III, Steven Alvin Tietje
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Patent number: 11236012Abstract: A glass-ceramic that includes: SiO2 from about 35 mol % to about 80 mol %; B2O3 from about 10 mol % to about 50 mol %; P2O5 from about 10 mol % to about 50 mol %; and an optional addition of one or more of CaO, MgO and Bi2O3 from 0 mol % to about 5 mol %, wherein the glass-ceramic further comprises a boron-phosphate crystalline phase.Type: GrantFiled: March 28, 2019Date of Patent: February 1, 2022Assignee: Corning IncorporatedInventors: George Halsey Beall, Heather Debra Boek, Ling Cai, Jin Su Kim, Dean Michael Thelen, Mark Owen Weller
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Publication number: 20220009160Abstract: The present invention relates to a paper-based 3D printing device and a printing method. The paper-based 3D printing device comprises a printing platform, a three-axis linkage platform, a cutting head and an inkjet head. The printing platform is used for placing paper, and the three-axis linkage platform is arranged to, firstly, drive the cutting head to cut the corresponding paper along the contour of a preset model to form a cutting seam, and then drive the inkjet head to inkjet color toward the cutting seam along the contour of the preset model. The paper-based 3D printing device and the printing method save ink, and can directly spray the ink at the cutting seam, which is equivalent to coloring the outer surface of the model, effectively improving the coloring effect, making the coloring of the outer surface of the model uniform, eliminating the step of printing one by one.Type: ApplicationFiled: August 17, 2020Publication date: January 13, 2022Inventors: Guangxue CHEN, Ling CAI, Linyi CHEN, Qifeng CHEN, Jiangping YUAN, Xiaochun WANG
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Publication number: 20210395134Abstract: An article including a glass having that includes SiO2, Al2O3, and B2O3 and least one of Li2O, Na2O, K2O, MgO, CaO, SrO, BaO, SnO2, ZnO, La2O3, F, and Fe2O3, wherein the glass includes a dielectric constant of about 10 or less and/or a loss tangent of about 0.01 or less, both as measured with signals at 10 GHz.Type: ApplicationFiled: August 18, 2021Publication date: December 23, 2021Inventors: Heather Debra Boek, Ling Cai, Jennifer Anella Heine, Lisa Ann Lamberson, Adama Tandia, Kochuparambil Deenamma Vargheese, Mark Owen Weller
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Patent number: 11182460Abstract: A computer implemented method, computer system and computer program product are provided for lost detection for paired mobile devices. According to the method, a processor receives behavior data of paired mobile devices from one or more sensors of the paired mobile devices, wherein the behavior data comprising one or more parameters that reflect current status of the paired mobile devices. And the processor compares the received behavior data with human behavior data model. And, in response to the received behavior data being not matched with the human behavior data model, the processor determines that at least one of the paired mobile devices is lost.Type: GrantFiled: October 17, 2018Date of Patent: November 23, 2021Assignee: International Business Machines CorporationInventors: Gui Song Huang, Hong Gang Liu, Wen Dong Wang, Xi Ling Cai, Li Zhen Zhou, Ting Li, Cui Su, Jing Wen Zhou
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Publication number: 20210328477Abstract: A motor, a cooling device, and a cooling method are disclosed. The cooling device is mounted on a stator of the motor. The cooling device includes a sleeve and a spiral duct. A wall of the sleeve has a spiral groove extending along the sleeve. The sleeve is sleeved onto the stator. The spiral duct is mounted in the spiral groove. The spiral duct has a first spiral form corresponding to the spiral groove, so that the spiral duct is correspondingly installed in the spiral groove. The spiral duct has a second spiral form extending along the spiral duct. A twisted spiral cooling channel is formed along the spiral pathway. A cooling fluid flowing through the twisted spiral cooling channel is subjected to the continuously changing cross-section of the twisted spiral cooling channel to enhance the swirl intensity, thereby improving the convection heat transfer effectiveness.Type: ApplicationFiled: November 30, 2020Publication date: October 21, 2021Inventors: MI-CHING TSAI, SHYY-WOEI CHANG, MIN-FU HSIEH, KAI-JUNG SHIH, WEI-LING CAI, JEN-HSIANG LIU
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Patent number: 11117828Abstract: An article including a glass having that includes SiO2, Al2O3, and B2O3 and least one of Li2O, Na2O, K2O, MgO, CaO, SrO, BaO, SnO2, ZnO, La2O3, F, and Fe2O3, wherein the glass includes a dielectric constant of about 10 or less and/or a loss tangent of about 0.01 or less, both as measured with signals at 10 GHz.Type: GrantFiled: March 4, 2020Date of Patent: September 14, 2021Assignee: Corning IncorporatedInventors: Heather Debra Boek, Ling Cai, Jennifer Anella Heine, Lisa Ann Lamberson, Adama Tandia, Kochuparambil Deenamma Vargheese, Mark Owen Weller