Abstract: Disclosed herein are systems, methods, and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.

Abstract: Disclosed herein are systems, methods, and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.

Abstract: The present invention discloses a production system and method for location-aware environment. The method comprises the following steps: making each of the gateways sense a test RSSI corresponded to a test position of the end device; obtaining a corresponded reference GPS parameter through finding corresponding data of the fingerprint positioning database according to the test RSSI; and determining the selected area is a location-aware completed area if a difference between the reference GPS parameter and the real GPS parameter is smaller than or equal to a preset error.

Abstract: The present invention discloses a production system and method for location-aware environment. The method comprises the following steps: making each of the gateways sense a test RS SI corresponded to a test position of the end device; obtaining a corresponded reference GPS parameter through finding corresponding data of the fingerprint positioning database according to the test RSSI; and determining the selected area is a location-aware completed area if a difference between the reference GPS parameter and the real GPS parameter is smaller than or equal to a preset error.

Abstract: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.

Abstract: Disclosed herein are systems, methods and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.

Abstract: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.

Abstract: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.

Abstract: A wireless packet relay apparatus is disclosed including: an RF module for receiving a streaming service request from a wireless set-top box; a network interface; and a processing circuit for performing a predetermined network connection authentication with the wireless set-top box via the RF module; wherein the processing circuit transmits the streaming service request to a multimedia streaming server via the network interface if the streaming service request is received by the RF module within a predetermined period.

Abstract: A wireless routing circuit is disclosed including: a first RF circuit having a first physical address for communicating with a first set of one or more wireless networking devices each has a gateway address configured as the first physical address; a second RF circuit having a second physical address for communicating with a second set of one or more wireless networking devices each has a gateway address configured as the second physical address; a processing circuit coupled with the first and second RF circuits for processing packets received or to be transmitted by the first and second RF circuits; and a network interface coupled with the processing circuit for communicating with one or more network areas under the control of the processing circuit.

Abstract: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.

Abstract: A panel of biomarkers has been identified for analysis of colorectal cancer. The panel, originally identified using a mouse colon cancer model, has been used to assess changes in human tissue from surgical and biopsy samples against a normal human control panel of biomarkers. The panel may be used for providing a cost effective, rapid, noninvasive procedure for risk assessment, early diagnosis, establishing prognosis, monitoring patient treatment, detecting relapse, and for the discovery of therapeutic intervention of colorectal cancer.

Abstract: New methods are disclosed for detecting cancer associated genes, and obtaining corresponding cDNA fragments. The methods involve supplying RNA preparations from control cells, and from a plurality of different cancer cells that share a duplicated or deleted gene in the same region of a chromosome. Amplified cDNA copies are displayed, and then selected based on differences in abundance of RNA between preparations. Optional additional screening steps involve surveying panels of cancer cells using the cDNA for RNA overabundance with or without gene duplication. By applying these methods, cDNA sequences derived from four novel genes associated with breast cancer were obtained and characterized. Each of the genes was duplicated in about 60% of the cancer cell lines tested; while other cells showed RNA overabundance without gene duplication. Genes with these properties are particularly useful in cancer diagnosis and treatment.

Abstract: cDNA sequences derived from four novel genes associated with breast cancer are provided. In over about 60% of the cancer cell lines tested, RNA hybridizing with the cDNAs were substantially more abundant than in normal cells. Most of the cell lines also showed a duplication of the corresponding gene, which probably contributed to the increased level of RNA in the cell. However, for each of the four genes, there were some cell lines which had RNA overabundance without gene duplication. This suggests that the gene product is sufficiently important to the cancer process that cells will use several alternative mechanisms to achieve increased expression. The polynucleotides, polypeptides, and antibodies provided by this invention are expected to be particularly useful in diagnosis and treatment of breast cancer. Also provided is a general method for obtaining cDNA with similar properties that may be associated with breast cancer and other malignancies.