Abstract: Provided herein are affinity matured anti-galectin-9 (Gal9) antibodies. The antibodies have improved binding affinity to Gal9. Also provided herein are method of use of the affinity matured anti-Gal9 antibodies, including methods of treatment of cancer, methods of rescuing or promoting effector T cell proliferation, methods of enhancing effector T cell activity, and/or of identifying and treating cancer in a subject including the administration of the anti-Gal9 antibodies described herein. Also provided are polynucleotides encoding the heavy chain or the light chain or the antigen-binding portion thereof described herein, and vectors, especially expression vectors, including the polynucleotides described herein.

Abstract: Systems and methods for a drilling machine. The drilling machine system, in one example, includes a gearbox with a planetary reduction and a floating input coupling directly coupled to or formed in a sun gear shaft that is included in the planetary reduction. Further, in the drilling machine system, the input coupling is unsupported by a bearing and rotational axes of the floating input and the sun gear shaft are coaxially arranged.

Abstract: The present invention provides a method for determining whether a mature cotton fiber includes Giza 94 (G94) variety of G. barbadense. The method comprises providing a mature cotton fiber from a manufactured article; extracting DNA from the mature cotton fiber; amplifying a portion of said DNA with a PCR-based technique using a primer set comprising SEQ ID NO: 1 and SEQ ID NO: 2, thereby producing one or more amplicons, generating a variable amplicon length polymorphism profile (VALP) from the amplicons, and comparing the generated VALP with a G94 variable amplicon length polymorphism profile, thereby determining whether the mature cotton fiber incudes G94.

Abstract: The present invention discloses a unit commitment method considering security region of wind turbine generators with frequency response control, and the main steps are: 1) determining security region of wind turbine generators when provides frequency response; 2) based on the security region of the wind turbine generators when provides frequency response, establishing a unit commitment model considering security region of wind turbine generators; and 3) calculating the unit commitment model considering the security region of the wind turbine generators by using mixed-integer linear programming method, and obtaining the operation result of the unit commitment considering the security region of the wind turbine generators with frequency response control. The present invention can be widely used in the setting of frequency response parameters of wind turbine generators dispatched in the prior art and the start-stop and output plans of synchronous generator.

Abstract: The present invention discloses a unit commitment method considering security region of wind turbine generators with frequency response control, and the main steps are: 1) determining security region of wind turbine generators when provides frequency response; 2) based on the security region of the wind turbine generators when provides frequency response, establishing a unit commitment model considering security region of wind turbine generators; and 3) calculating the unit commitment model considering the security region of the wind turbine generators by using mixed-integer linear programming method, and obtaining the operation result of the unit commitment considering the security region of the wind turbine generators with frequency response control. The present invention can be widely used in the setting of frequency response parameters of wind turbine generators dispatched in the prior art and the start-stop and output plans of synchronous generator.

Abstract: A wireless controller (200) is configured to send commands to a mini-split HVAC unit (100) that thermostatically controls a temperature in a space (50) using the temperature sensed and a programmable set point. The wireless controller (212) may include an infrared (IR) transmitter (208), a temperature sensor (210), a user interface (214), a non-volatile memory (202), and a controller (212). The wireless controller (200) may store an IR database in the non-volatile memory (202) for each of a wide variety of mini-split HVAC unit (100). The wireless controller (200) may then allow a user to select a particular mini-split HVAC unit (100), and from the selection may identify a corresponding IR protocol in the IR database. During subsequent use, the wireless controller (200) may use the corresponding IR protocol during subsequent communication with the mini-split HVAC unit (100).

Abstract: A wireless controller (200) is configured to send commands to a mini-split HVAC unit (100) that thermostatically controls a temperature in a space (50) using the temperature sensed and a programmable set point. The wireless controller (212) may include an infrared (IR) transmitter (208), a temperature sensor (210), a user interface (214), a non-volatile memory (202), and a controller (212). The wireless controller (200) may store an IR database in the non-volatile memory (202) for each of a wide variety of mini-split HVAC unit (100). The wireless controller (200) may then allow a user to select a particular mini-split HVAC unit (100), and from the selection may identify a corresponding IR protocol in the IR database. During subsequent use, the wireless controller (200) may use the corresponding IR protocol during subsequent communication with the mini-split HVAC unit (100).

Abstract: The invention relates to the fields of medicines, chemistry, and food products, and specifically relates to a rolling mold combination device, a method using a rolling mold to prepare a freeze-dried excipient, and a product thereof. The method has the advantage of being able to engrave any character or pattern at any part of a mold, and correspondingly, can produce the character or pattern at any part of a manufactured product, including a product name or trademark, and such an effect cannot be obtained in existing freeze-dried excipient products. The manufactured product can be designed to be any shape and does not readily break inside packaging, reducing loss of medicines and enabling accurate dosages thereof. The method of preparing a freeze-dried excipient adopts mold-release freeze-drying, and a mold does not re-enter a freeze-drying step, improving production efficiency, decreasing production cost, saving energy and protecting the environment.

Abstract: Disclosed are a freeze-drying excipient preparation of an arbitrary shape and a preparation method therefor, and in particular a method for preparing a freeze-drying excipient preparation of an arbitrary shape mainly containing an active ingredient and a binder by using multiple moulds, and a product prepared by the method.