Abstract: There is provided a video-based automated detection method for epileptic seizure behavior of an animal. The method includes providing an epileptic seizure detection dataset for an animal, constructing a deep learning framework by applying a transfer learning with a spatial-temporal network (STN) to localize and detect seizure behavior of the animal based on the epileptic seizure detection dataset, and detecting epileptic seizure behavior of the animal from raw video frames based on the deep learning framework.

Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: A method for a method of prophylaxis and/or therapy of neurological conditions in a subject in need thereof includes the step of administrating a recombinant AAV vector to the subject. Also disclosed is the use of the a recombinant AAV vector in the manufacture of a medicament of prophylaxis and/or therapy of neurological conditions in a subject in need thereof. The recombinant AAV vector includes: PHP.eB; a sequence for introducing the expression of human M3 muscarinic DREADD receptor coupled to Gq (hM3Dq); and an inhibitory neuron-specific Distal-less homeobox (Dlx) gene enhancer sequence.

Abstract: Provided are single domain antibodies that bind to GUCY2C, and chimeric antigen receptors comprising same. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating a disease or disorder are also provided.

Abstract: Provided are a chimeric antigen receptor, a construction method therefor and an application thereof. The chimeric antigen receptor consists of an antigen binding domain, an extracellular hinge region, a transmembrane domain, a co-stimulatory domain and a CD3z signaling domain. Further provided is a CAR-T cell which comprises two chimeric antigen receptors containing different antigen binding domains, and which is bispecific and exhibits increased cell killing efficiency and a better tumor inhibitory effect in vivo.

Abstract: Provided are allogeneic CAR-T cells prepared by expressing related functional proteins in T cells and regulating HLA class I molecules on the cell surface. Also provided is the use of the allogeneic CAR-T cells.

Abstract: The present invention provides an oligonucleotide conjugate with high hybridization performance and use thereof. The oligonucleotide conjugate of the present invention can be used as a probe for nucleic acid detection, the oligonucleotide conjugate of the present invention can be used to design probes more flexibly, and the conservative regions are more accessible. The specificity of the probe is better, and the fluorescence value of the probe can be significantly improved, the fluorescence background is significantly reduced, and the sensitivity of the probe is greatly improved.

Abstract: Provided is an engineered T cell. The expression level of an HLA class I molecule on the surface of the T cell is down-regulated to 10-50% of that of a non-engineered T cell. The expression of the T cell down-regulates a functional protein of the HLA class I molecule. The functional protein down-regulates at least one of HLA-A, HLA-B, and HLA-E molecules of the HLA class I molecule. The T cell may be an allogeneic CAR-T cell. Also provided is an application of the T cell or the allogeneic CAR-T cell.

Abstract: An Ethernet power sourcing equipment (PSE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: An Ethernet power sourcing equipment (P SE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: An Ethernet power sourcing equipment (PSE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: Provided is a lighting system driver including a damper circuit. A power circuit is coupled to the damper circuit and includes a first portion of a winding of a transformer. Also included is an oscillating control circuit including a second portion of the winding of the transformer.

Abstract: An Ethernet power sourcing equipment (PSE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: This application provides a capacitive fingerprint recognition module, including a substrate, a fingerprint recognition chip, a mold compound, a chip adhesive layer, and a cover plate. The mold compound and the fingerprint recognition chip are disposed on the substrate, and the mold compound packages the fingerprint recognition chip. The cover plate is covered on the chip adhesive layer, so that a squeezed part of the chip adhesive layer is squeezed beyond an edge of the cover plate and is exposed outside. The chip adhesive layer is selected from a non-white material, and therefore the squeezed part of the chip adhesive layer is visually hidden. By means of the configuration, a process of clearing the squeezed part of the chip adhesive layer may be omitted.

Abstract: A heat dissipation simulator of a component on a printed circuit board (PCB) includes a simulation board and a simulated heat source. The simulation board includes an iron layer and a plastic layer. The simulated heat source includes a simulation chip, a thermal, and a heat sink. The simulation chip, the thermal piece, and the heat sink are mounted on the simulation board in that order. The heat dissipation simulator replaces a sample of the PCB with the component for simulating working states of the component on the PCB.

Abstract: A technique for acquiring a web page includes: receiving, at a client, a user instruction; obtaining from the instruction a page number of a web page that a user desires to access; searching for web page data in a hidden form that is cached in advance at the client, the search being based at least in part on the page number and the hidden form comprising web page data for a plurality of page numbers and in the event that web page data is found in the hidden form, generating, by the client, the web page using the web page data.

Abstract: Provided is a lighting system driver including a damper circuit. A power circuit is coupled to the damper circuit and includes a first portion of a winding of a transformer. Also included is an oscillating control circuit including a second portion of the winding of the transformer.

Abstract: A technique for acquiring a web page includes: receiving, at a client, a user instruction; obtaining from the instruction a page number of a web page that a user desires to access; searching for web page data in a hidden form that is cached in advance at the client, the search being based at least in part on the page number and the hidden form comprising web page data for a plurality of page numbers and in the event that web page data is found in the hidden form, generating, by the client, the web page using the web page data.

Abstract: A wind charger set on a circuit board for powering a button cell held by a holder set on the circuit board. The wind charger includes a bracket attached to the holder, a wind turbine fixed on the bracket and a charge circuit. The charge circuit is set on the circuit board. The wind turbine transfers airflow created by a heat-dissipating device set on the circuit board into electricity for powering the charge circuit, which charges the button cell.

Abstract: Preventing web crawler access includes receiving a request for a webpage that includes web content that is to be protected from a web crawler, encrypting the web content to be protected to generate encrypted content and responding to the request, including sending the encrypted content and a decryption instruction. The decryption instruction is configured to allow a web browser to decrypt the encrypted content.