Abstract: A light-emitting device includes a substrate and an epitaxial structure. The epitaxial structure includes a first semiconductor layer, an active layer, and a second semiconductor layer which are disposed on the upper surface of the substrate in such order. The substrate has a substrate edge region surrounding and exposed from the epitaxial structure. The substrate edge region includes a first substrate edge region and a second substrate edge region which is more proximate to the epitaxial structure than the first substrate edge region. The first substrate edge region has a first uneven toothed surface or an even flat surface. The second substrate edge regions are formed with second uneven toothed surfaces which have a height greater than a height of the first even toothed surface, or the even flat surface.

Abstract: A bidirectional reflectance distribution function (BRDF) measurement system and method, an electronic device, and a storage medium. The BRDF measurement system includes: a blackbody, a spectroradiometer and a controller; where in case that the blackbody is heated to a target temperature, it undergoes a solid-liquid phase change; the spectroradiometer is used to measure the blackbody and transmit a first measurement signal to the controller, and in case that the blackbody irradiates a to-be-measured point on a sample surface, the spectroradiometer is further used to measure radiation from the to-be-measured point, and transmit a second measurement signal to the controller; and the controller is used to obtain a BRDF of the to-be-measured point based on the first measurement signal, the second measurement signal, the target geometric relationship, a target mapping relationship and a dimension parameter of the blackbody.

Abstract: Disclosed herein are, inter alia, inhibitors of protein arginine methyltransferase 9 and pharmaceutical compositions thereof, and methods comprising the use of protein arginine methyltransferase 9 inhibitors for the treatment of a protein arginine methyltransferase 9-modulated disease or disorder, such as a hematological cancer.

Abstract: Disclosed is an electronic device including a display module and a camera module. The display module includes a first substrate and a second substrate stacked with each other, and a routing structure arranged on a surface of one side of the second substrate facing towards the first substrate, and provided with a first light-passing hole. The camera module includes a camera body and a light-shielding layer arranged on a surface of one side of the first substrate away from the second substrate and provided with a light inlet hole and a second light-passing hole. The first light-passing hole, the second light-passing hole, and the light inlet hole are arranged in an optical axis direction of the camera module. An orthographic projection of the first light-passing hole and the second light-passing hole on a surface perpendicular to the optical axis direction fall within an orthographic projection of the light inlet hole.

Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: A keyboard device includes a key module and a backlight module. The key module includes a supporting plate and plural key structures. The key structures are installed on the supporting plate. The backlight module includes a light guide plate, a light-sheltering layer, a reflecting layer, a light-emitting unit, a base plate and an opaque structure. The light guide plate includes a second opening. The second opening includes a lateral wall. The light-sheltering layer is located over the light guide plate. The light-sheltering layer includes a third opening. The reflecting layer is located under the light guide plate. The reflecting layer includes a fourth opening. The light-emitting unit emits a light beam into the light guide plate. The opaque structure is arranged between the light-sheltering layer and the reflecting layer. The opaque structure is located beside the lateral wall of the light guide plate.

Abstract: An active noise control (ANC) circuit is used for generating an anti-noise signal, and has a plurality of filters including at least one first filter and at least one second filter. The at least one first filter generates at least one first filter output, wherein each of the at least one first filter has at least one non-static filter and at least one static filter connected in a series fashion. The at least one second filter generates at least one second filter output, wherein each of the at least one second filter has at least one adaptive filter. The anti-noise signal is jointly controlled by the at least one first filter output and the at least one second filter output. The at least one first filter and the at least one second filter are connected in a parallel fashion.

Abstract: A method for a method of prophylaxis and/or therapy of neurological conditions in a subject in need thereof includes the step of administrating a recombinant AAV vector to the subject. Also disclosed is the use of the a recombinant AAV vector in the manufacture of a medicament of prophylaxis and/or therapy of neurological conditions in a subject in need thereof. The recombinant AAV vector includes: PHP.eB; a sequence for introducing the expression of human M3 muscarinic DREADD receptor coupled to Gq (hM3Dq); and an inhibitory neuron-specific Distal-less homeobox (Dlx) gene enhancer sequence.

Abstract: Provided are single domain antibodies that bind to GUCY2C, and chimeric antigen receptors comprising same. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating a disease or disorder are also provided.

Abstract: Provided are a chimeric antigen receptor, a construction method therefor and an application thereof. The chimeric antigen receptor consists of an antigen binding domain, an extracellular hinge region, a transmembrane domain, a co-stimulatory domain and a CD3z signaling domain. Further provided is a CAR-T cell which comprises two chimeric antigen receptors containing different antigen binding domains, and which is bispecific and exhibits increased cell killing efficiency and a better tumor inhibitory effect in vivo.

Abstract: Provided are allogeneic CAR-T cells prepared by expressing related functional proteins in T cells and regulating HLA class I molecules on the cell surface. Also provided is the use of the allogeneic CAR-T cells.

Abstract: The present invention provides an oligonucleotide conjugate with high hybridization performance and use thereof. The oligonucleotide conjugate of the present invention can be used as a probe for nucleic acid detection, the oligonucleotide conjugate of the present invention can be used to design probes more flexibly, and the conservative regions are more accessible. The specificity of the probe is better, and the fluorescence value of the probe can be significantly improved, the fluorescence background is significantly reduced, and the sensitivity of the probe is greatly improved.

Abstract: Provided is an engineered T cell. The expression level of an HLA class I molecule on the surface of the T cell is down-regulated to 10-50% of that of a non-engineered T cell. The expression of the T cell down-regulates a functional protein of the HLA class I molecule. The functional protein down-regulates at least one of HLA-A, HLA-B, and HLA-E molecules of the HLA class I molecule. The T cell may be an allogeneic CAR-T cell. Also provided is an application of the T cell or the allogeneic CAR-T cell.

Abstract: An Ethernet power sourcing equipment (PSE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: An Ethernet power sourcing equipment (P SE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: An Ethernet power sourcing equipment (PSE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: Provided is a lighting system driver including a damper circuit. A power circuit is coupled to the damper circuit and includes a first portion of a winding of a transformer. Also included is an oscillating control circuit including a second portion of the winding of the transformer.

Abstract: An Ethernet power sourcing equipment (PSE), and a method and an apparatus for power over Ethernet (PoE), where the Ethernet PSE includes a PSE chip, a master control processor, a power supplying port, and a preprocessor. The preprocessor is configured to determine whether the master control processor starts upon power-on, control the PSE chip to detect whether the power supplying port is connected to a valid powered device (PD) when the master control processor starts upon power-on, and control, according to a preset rule, the PSE chip to power on the valid PD when the power supplying port is connected to the valid PD. Hence, the Ethernet PSE has abundant management functions and can quickly power on a PD.

Abstract: This application provides a capacitive fingerprint recognition module, including a substrate, a fingerprint recognition chip, a mold compound, a chip adhesive layer, and a cover plate. The mold compound and the fingerprint recognition chip are disposed on the substrate, and the mold compound packages the fingerprint recognition chip. The cover plate is covered on the chip adhesive layer, so that a squeezed part of the chip adhesive layer is squeezed beyond an edge of the cover plate and is exposed outside. The chip adhesive layer is selected from a non-white material, and therefore the squeezed part of the chip adhesive layer is visually hidden. By means of the configuration, a process of clearing the squeezed part of the chip adhesive layer may be omitted.

Abstract: A heat dissipation simulator of a component on a printed circuit board (PCB) includes a simulation board and a simulated heat source. The simulation board includes an iron layer and a plastic layer. The simulated heat source includes a simulation chip, a thermal, and a heat sink. The simulation chip, the thermal piece, and the heat sink are mounted on the simulation board in that order. The heat dissipation simulator replaces a sample of the PCB with the component for simulating working states of the component on the PCB.