Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.

Abstract: A method for constructing a body-in-white (BiW) spot welding deformation prediction model based on a graph convolutional network (GCN) includes: 1) acquiring a welding feature and 3D coordinates of a spot weld to form an eigenvector and extracting designed 3D coordinates at each 3D coordinate measurement point; 2) encoding, by an encoder, eigenvectors and designed 3D coordinate vectors into hidden space vectors of spot welds and hidden space vectors of the coordinate measurement points, respectively, and constructing a graph topology G through a k-nearest neighbors algorithm; 3) decomposing a Laplacian eigenvector of the constructed graph topology G to acquire frequency domain components, and linearly transforming eigenvalues corresponding to the frequency domain components to construct a multi-layer GCN; 4) inputting the thermodynamic and kinetic information of each coordinate measurement point into a deep neural network and decoding a final deformation at each coordinate measurement point; and 5) optimizing

Abstract: A modulo divider and a modulo division operation method for binary data are provided, including: converting a first variant and a second variant to a variant set according to a first mapping table; generating a fifth variant and a sixth variant according to the variant set; generating a seventh variant and an eighth variant according to the variant set; updating the first variant according to one of the fifth variant and the sixth variant and updating the second variant according to the other one of the fifth variant and the sixth variant; updating the third variant according to one of the seventh variant and the eighth variant and updating the fourth variant according to the other one of the seventh variant and the eighth variant; and outputting the third variant as a result of a modulo division operation in response to determining the updating of the third variant being finished.

Abstract: A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.

Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.

Abstract: A modular multiplication circuit includes a main operation circuit, a look-up table, and an addition unit. The main operation circuit updates a sum value and a carry value according to 2iA corresponding to a first operation value A and m bits of a second operation value B currently under operation, m is a positive integer, i is from 0 to m?1. The look-up table records values related to a modulus, and selects one of the values as a look-up table output value according to the sum value. The addition unit updates the sum value and the carry value according to the look-up table output value and outputs the updated sum value and the updated carry value to the main operation circuit. The modular multiplication circuit updates the sum value and the carry value in a recursive manner by using m different bits of the second operation value B.

Abstract: Intraoral appliances are disclosed that provide electrical stimulation to tissue in a patient's oral cavity in a manner that reduces apnea events during sleep. A representative appliance can induce a current or currents through tissue and/or anatomical structures in a manner that maintains upper airway tone and/or patency.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device including a flexible portion that is suited to access target anatomy. The flexibility of an elongate portion of the delivery device can be varied. Additionally, the delivery device can include structure that maintains the positioning of the delivery device in patient anatomy.

Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: A modular multiplication circuit includes a main operation circuit, a look-up table, and an addition unit. The main operation circuit updates a sum value and a carry value according to 2iA corresponding to a first operation value A and m bits of a second operation value B currently under operation, m is a positive integer, i is from 0 to m-1. The look-up table records values related to a modulus, and selects one of the values as a look-up table output value according to the sum value. The addition unit updates the sum value and the carry value according to the look-up table output value and outputs the updated sum value and the updated carry value to the main operation circuit. The modular multiplication circuit updates the sum value and the carry value in a recursive manner by using m different bits of the second operation value B.

Abstract: A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.

Abstract: A method for constructing a body-in-white (BiW) spot welding deformation prediction model based on a graph convolutional network (GCN) includes: 1) acquiring a welding feature and 3D coordinates of a spot weld to form an eigenvector and extracting designed 3D coordinates at each 3D coordinate measurement point; 2) encoding, by an encoder, eigenvectors and designed 3D coordinate vectors into hidden space vectors of spot welds and hidden space vectors of the coordinate measurement points, respectively, and constructing a graph topology G through a k-nearest neighbors algorithm; 3) decomposing a Laplacian eigenvector of the constructed graph topology G to acquire frequency domain components, and linearly transforming eigenvalues corresponding to the frequency domain components to construct a multi-layer GCN; 4) inputting the thermodynamic and kinetic information of each coordinate measurement point into a deep neural network and decoding a final deformation at each coordinate measurement point; and 5) optimizing

Abstract: A system and associated method for altering or destroying tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders. In one aspect, the system includes a device configured to deploy devices for altering the lobes of a prostate.

Abstract: Intraoral electrical stimulation devices are disclosed. A representative device, which can be used to treat sleep apnea, includes an intraoral attachment body, a guide element carried by the attachment body and having a constrained guide path, and an electrode movably supported relative to the guide element and movable along the constrained guide path to a plurality of positions. A positioning member is coupleable to the electrode to move the electrode along the constrained guide path, and a signal generator is coupleable to the electrode to direct a stimulation signal to the electrode.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device including a flexible portion that is suited to access target anatomy. The flexibility of an elongate portion of the delivery device can be varied. Additionally, the delivery device can include structure that maintains the positioning of the delivery device in patient anatomy.

Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device including a flexible portion that is suited to access target anatomy. The flexibility of an elongate portion of the delivery device can be varied. Additionally, the delivery device can include structure that maintains the positioning of the delivery device in patient anatomy.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device and a plurality of anchor assemblies. The delivery system is configured to deliver a first anchor using loaded energy and reload the energy required to deliver an addition anchor.