Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: The present application discloses a biological valve material which is a swim bladder derived biological valve material. The present application also discloses a method for preparing the biological valve material, includes: decellularizing a raw swim bladder; and cross-linking the decellularized swim bladder with a cross-linking agent. The present application also discloses use of the biological valve material, wherein the biological valve material is used for preparing one or more of a biological heart valve, a biological patch, and an artificial blood vessel. The present application also discloses a cross-linking agent for a bio-based material, including a cross-linking compound and an organic solvent. The cross-linking compound includes a polyphenol compound. The present application also discloses use of the cross-linking agent, wherein the cross-linking agent is used to cross-link the bio-based material after the decellularization treatment.

Abstract: A microfluidic device and method comprises a rotatable substrate configured to be rotated at various angular velocities in order to accomplish a series of media exchanges with a sample chamber for containing a sample. A plurality of media reservoirs and waste reservoirs are connected to the sample chamber via channels forming capillary valves in which the capillary valves have varying burst frequencies of rotation of the substrate. The substrate can then be rotated through a series of angular velocities to automate media exchanges between the sample chamber and the respective media reservoirs and waste reservoirs. A pair of media reservoirs are located radially inward of the sample chamber and a pair of waste reservoirs are located radially outward of the sample chamber in an “X” configuration such that centrifugal forces cause fluid media to open the capillary valves and flow among the sample chamber, media reservoirs and waste reservoirs.

Abstract: A method for increasing the expression of SIRT1 mRNA and/or decreasing the expression of SOCS3 mRNA, and especially for regulating blood glucose levels in a subject in need thereof is provided. The method comprises administering to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein X is H or C1-C3 alkyl; one of Y and Z is and the other one is H, OH or wherein when Y is Z is R1 to R13 are independently H or OH, and wherein, R1 to R3 are not simultaneously H; R8 and R9 are not simultaneously H.

Abstract: A method for enhancing sauce flavor including steps of: collection, dilution, denaturation, enzymolysis, enzyme deactivation, centrifugation, secondary enzymolysis, deodorization, Maillard reaction, seasoning, dosing and flexible sterilization of a raw material, salted duck egg white. The by-product, salted duck egg white, not fully used in the food processing industry is recycled as a raw material, which not only saves the cost but also can protect the environment. Hydrolyzed animal protein is obtained through double-enzyme fractional hydrolysis. The degree of hydrolysis is high. The obtained hydrolyzed protein contains no trichloropropanol and is relatively safe, and flavourzyme decomposes bitter peptide, to make the hydrolysate not taste bitter. Some yeast, cooking wine and essence with unique flavor are chosen. Each ingredient is in a reasonable proportion, and the obtained product is delicious and of mellow flavor.

Abstract: The present invention is to provide a two-stage sterilization process for treating heat-resistant spores in a great burdock extract drink, which comprises the steps of sealing dried great burdock and water in a double-kettle pressure cooker; heating liquid mixture of great burdock and water to a first temperature range lower than or equal to 100° C. for at least a first duration during a first-stage sterilization; opening lid of the cooker and filtering out great burdock residue so that all that remains in the cooker is great burdock extract; resealing the cooker and heating the great burdock extract to a second temperature range higher than or equal to 120° C. for at least a second duration during a second-stage sterilization, and the pressure in the cooker during the second-stage sterilization is higher than that during the first-stage sterilization; so as to obtain the extract drink free of common bacteria and heat-resistant spores.

Abstract: A microfluidic device and method comprises a rotatable substrate configured to be rotated at various angular velocities in order to accomplish a series of media exchanges with a sample chamber for containing a sample. A plurality of media reservoirs and waste reservoirs are connected to the sample chamber via channels forming capillary valves in which the capillary valves have varying burst frequencies of rotation of the substrate. The substrate can then be rotated through a series of angular velocities to automate media exchanges between the sample chamber and the respective media reservoirs and waste reservoirs. A pair of media reservoirs are located radially inward of the sample chamber and a pair of waste reservoirs are located radially outward of the sample chamber in an “X” configuration such that centrifugal forces cause fluid media to open the capillary valves and flow among the sample chamber, media reservoirs and waste reservoirs.

Abstract: A method for increasing the expression of SIRT1 mRNA and/or decreasing the expression of SOCS3 mRNA, and especially for regulating blood glucose levels in a subject in need thereof is provided. The method comprises administering to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein X is H or C1-C3 alkyl; one of Y and Z is and the other one is H, OH or wherein when Y is Z is R1 to R13 are independently H or OH, and wherein, R1 to R3 are not simultaneously H; R8 and R9 are not simultaneously H.

Abstract: A method for increasing the expression of SIRT1 mRNA and/or decreasing the expression of SOCS3 mRNA, and especially for regulating blood glucose levels in a subject in need thereof is provided. The method comprises administering to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein X is H or C1-C3 alkyl; one of Y and Z is and the other one is H, OH or wherein when Y is Z is R1 to R13 are independently H or OH, and wherein, R1 to R3 are not simultaneously H; R8 and R9 are not simultaneously H.

Abstract: A method for increasing the expression of SIRT1 mRNA and/or decreasing the expression of SOCS3 mRNA, and especially for regulating blood glucose levels in a subject in need thereof is provided. The method comprises administering to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein X is H or C1-C3 alkyl; one of Y and Z is and the other one is H, OH or wherein when Y is Z is R1 to R13 are independently H or OH, and wherein, R1 to R3 are not simultaneously H; R8 and R9 are not simultaneously H.

Abstract: A system for determining a list of potential lots for consolidation is presented. The system includes a module having a database and an input for receiving an event occurrence. The database may include a set of consolidation rules. The module, upon receiving the event occurrence, retrieves the consolidation rules and initiates a consolidation analysis to determine the list of potential lots for consolidation based on the consolidation rules.

Abstract: A rotary connection apparatus comprising a bottom bracket, a top bracket rotatably connected to the bottom bracket, an annular spacer and a plurality of balls. The spacer and the balls are received between the bottom bracket and the top bracket. A thickness of the spacer is less than a diameter of the balls, and the spacer includes a plurality of holding holes, each holding hole has two openings exposed at opposite surfaces of the spacer, and a diameter of each of the openings is less than that of the balls, and a diameter of a central portion of each holding hole is equal to the diameter of the balls; each of the holding holes accommodates one corresponding ball, and each ball has opposite end portions protruding out of the spacer. A spacer is also provided.

Abstract: Novel chemopreventive and chemotherapeutic cancer treatment method using elemental selenium nanoparticles. Cancer cells, especially androgen dependent prostate cancers are exposed to selenium from elemental selenium nanoparticle treatment, and apoptosis is induced in the cancer cells.

Abstract: A method and apparatus to treat a subterranean formation including introducing a fluid comprising degradable material into a wellbore, contacting a surface of the wellbore with the fluid, and stimulating a surface of a subterranean formation, wherein the contacting the wellbore surface and stimulating the formation occur over a time period that is tailored by the properties of the degradable material. In some embodiments, the properties of the degradable material include a chemical composition, a surface area, a geometric shape of a particle of the material, a concentration of the material in the fluid, a density of the material, a dimension of a particle of the material, or a combination thereof.

Abstract: A manufacturing method of separating and purifying neoagarooligosaccharides having degrees of polymerization of 2-22 includes the steps of adding crude enzyme solutions with agarases produced by Pseudomonas vesicularis MA103 and Aeromonas salmonicida MAEF108, respectively, into an agar polysaccharide extract solution, and obtaining a neoagarooligosaccharides solution after a hydrolysis on the algal polysaccharide (such as agar) is performed; performing a separation to the neoagarooligosaccharides solution by a ultrafiltration (UF) system to obtain a neoagarooligosaccharide eluent; performing a separation to the neoagarooligosaccharide eluent by a semi-preparative high-performance liquid chromatography system equipped with a molecule size exclusion chromatography function to obtain the neoagarooligosaccharides having the degrees of polymerization from 2 to 22; and using a fraction collector to collect the neoagarooligosaccharides, and obtaining purified single neoagarooligosaccharide products with different mo

Abstract: A system for determining a list of potential lots for consolidation is presented. The system includes a module having a database and an input for receiving an event occurrence. The database may include a set of consolidation rules. The module, upon receiving the event occurrence, retrieves the consolidation rules and initiates a consolidation analysis to determine the list of potential lots for consolidation based on the consolidation rules.

Abstract: A composition for treatment of a subterranean formation, which may be used for water control, is comprised of at least one of 1) a premix of an oleochemical polyol, at least one of polyisocyanate, polycyanate and polyisothiocyanate, and a blocking agent to temporarily block all or a portion of free reactive groups of said at least one of polyisocyanate, polycyanate and polyisothiocyanate. Alternatively, or in addition, the composition may be comprised of a solvent and 2) a polyurethane prepolymer formed by reacting an oleochemical polyol and at least one of polyisocyanate, polycyanate and polyisothiocyanate. A blocking agent may also be used with the polyurethane prepolymer. The composition may be used in a method of treating a subterranean formation penetrated by a wellbore by introducing the composition into the formation through the wellbore.

Abstract: A particle embedded with chemical substances, especially with physiological activity substances, is disclosed. The particle has (a) the embedded substances, embedded in base materials and ranged from about 0.1 to 70% by weight based on the total weight of the particle; and (b) the base material, selected from hydrogenated plant oil, hydrogenated animal oil, C8-C64 saturated fatty acid or the derivatives thereof, and ranged from about 30 to 99.9% by weight based on the total weight of the particle. Also, the present invention discloses a method for producing the particle.