Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: A closed-loop perfusion system may include a sealed biological culture container configured to house a biological cell culture, and a filtering unit that permits passage of waste products from an output of the sealed biological cell culture container, permits passage of nutrients from a nutrient media solution, and blocks passage of beneficial molecules from the output of the sealed biological cell culture container. The system may further include a first fluid path between an output of the sealed biological cell culture container and an input of the filtering unit, a second fluid path between an output of the filtering unit and an input of the sealed biological cell culture, and a pump to control the flow of media through the first fluid path and the second fluid path.

Abstract: In one embodiment, a method receives a first bundle and a second bundle for a video based on metadata for the video. The method stores the second bundle with a dependency on the first bundle when the second bundle is associated with a first set of control data parameters found in the first bundle that control a first aspect of access to the video. The second bundle is stored with a second set of control data parameters to control a second aspect of access to the video. When the first bundle is selected, the method accesses the first set of control data parameters for the first bundle. When the second bundle is selected, the method accesses the first set of control data parameters in the first bundle via the dependency to the first bundle and the second set of control data parameters for the second bundle.

Abstract: In one embodiment, a method receives a first bundle and a second bundle for a video based on metadata for the video. The method stores the second bundle with a dependency on the first bundle when the second bundle is associated with a first set of control data parameters found in the first bundle that control a first aspect of access to the video. The second bundle is stored with a second set of control data parameters to control a second aspect of access to the video. When the first bundle is selected, the method accesses the first set of control data parameters for the first bundle. When the second bundle is selected, the method accesses the first set of control data parameters in the first bundle via the dependency to the first bundle and the second set of control data parameters for the second bundle.

Abstract: In one embodiment, a method receives information for a video entity where a video delivery system delivers the video entity as a plurality of video assets using different video delivery methods. The method generates bundles for the video assets. Also, dependencies are generated between bundles when two bundles include control data parameters that are the same. The method then stores control data parameters for the bundles for the plurality of video assets based on the dependencies. A second bundle is stored with the dependency on a first bundle and the second bundle includes a second set of control data parameters for the second bundle that is different from the first set of control data parameters included in the first bundle. When the second bundle is selected, the method accesses the first set of control data parameters and the second set of control data parameters for the second bundle.

Abstract: In one embodiment, a method receives information for a video entity where a video delivery system delivers the video entity as a plurality of video assets using different video delivery methods. The method generates bundles for the video assets. Also, dependencies are generated between bundles when two bundles include control data parameters that are the same. The method then stores control data parameters for the bundles for the plurality of video assets based on the dependencies. A second bundle is stored with the dependency on a first bundle and the second bundle includes a second set of control data parameters for the second bundle that is different from the first set of control data parameters included in the first bundle. When the second bundle is selected, the method accesses the first set of control data parameters and the second set of control data parameters for the second bundle.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to Web services construction and provide a novel and non-obvious method, system and computer program product for message-oriented Web services construction. A method for the message oriented construction of a Web service can include graphically assembling a selection of message flow primitives defining an operation for a Web service, interconnecting selected ones of the message flow primitives to represent a flow of messages from one interconnected message flow primitive to another interconnected message flow primitive, and generating Web service logic from the selection of message flow primitives. The method further can include interpreting or executing the Web service logic in response to receiving a request to invoke the Web service.

Abstract: Continuous cell lines that are highly permissive to infection by porcine circovirus type 2 (“PCV2”) are described. PCV2 is the causal agent of post-weaning multi-systemic wasting syndrome (“PMWS”) in pigs. PMWS has emerged as a major disease that poses a significant threat to the economics of global swine industry. The highly permissive cell lines of this invention provide efficient and reliable sources of PCV2 for use in development of vaccines, therapies and diagnostic agents for PMWS.

Abstract: Vendor information relating to a plurality of vendors is transmitted to an employer. The vendor information of each vendor includes a respective offering of the vendor, including a description and cost of the offering. A selection of a respective offering of a vendor is received from the employer, including a co-payment amount the employer is willing to contribute. A benefits package is created including the selected offering and the co-payment amount. An invitation to participate in the benefits package is transmitted to an employee of the employer. An acceptance of the invitation to participate in the benefits package is received from the employee. The employer is charged the co-payment amount and the employee is charged an amount equal to the cost of the offering net of the co-payment amount and an order for the offering is created on behalf of the employee.

Abstract: The present invention generally comprises one or more cooled anodes shadowing one or more gas introduction tubes where both the cooled anodes and the gas introduction tubes span a processing space defined between one or more sputtering targets and one or more substrates within a sputtering chamber. The gas introduction tubes may have gas outlets that direct the gas introduced away from the one or more substrates. The gas introduction tubes may introduce reactive gas, such as oxygen, into the sputtering chamber for depositing TCO films by reactive sputtering. During a multiple step sputtering process, the gas flows (i.e., the amount of gas and the type of gas), the spacing between the target and the substrate, and the DC power may be changed to achieve a desired result.

Abstract: The present invention relates to a hand sensory assessment device capable of point localization, two-point discrimination, vibration, and texture discrimination for assessing and training patients. The device possesses multiples of pins serving as contacting points that are capable of treating multiples points on a patients hand.

Abstract: Continuous cell lines that are highly permissive to infection by porcine circovirus type 2 (“PCV2”) are described. PCV2 is the causal agent of post-weaning multi-systemic wasting syndrome (“PMWS”) in pigs. PMWS has emerged as a major disease that poses a significant threat to the economics of global swine industry. The highly permissive cell lines of this invention provide efficient and reliable sources of PCV2 for use in development of vaccines, therapies and diagnostic agents for PMWS.

Abstract: The present invention relates to a hand sensory assessment device capable of point localization, two-point discrimination, vibration, and texture discrimination for assessing and training patients. The device possesses multiples of pins serving as contacting points that are capable of treating multiples points on a patients hand.

Abstract: A physical vapor deposition (PVD) apparatus and a PVD method are disclosed. Extending an anode across the processing space between the target and the substrate may increase deposition uniformity on a substrate. The anode provides a path to ground for electrons that are excited in the plasma and may uniformly distribute the electrons within the plasma across the processing space rather than collect at the chamber walls. The uniform distribution of the electrons within the plasma may create a uniform deposition of material on the substrate. The anodes may be cooled with a cooling fluid to control the temperature of the anodes and reduce flaking. The anodes may be disposed across the process space perpendicular to the long side of a magnetron that may scan in two dimensions across the back of the sputtering target. The scanning magnetron may reduce localized heating of the anode.

Abstract: A vacuum having a series of motors and fans. As the fans rotate, they draw air into the vacuum. The volume of the air brought into the vacuum is maximized by positioning the fans in series. A plurality of fans is positioned so that outflow from a first fan is the primary inflow into a second fan, and so forth. Together the fans will draw more air than one could alone. By positioning the fans in series, the external diameter of the vacuum does not need to be any larger than it would for a vacuum having a single fan. The fans and motors are contained in a housing having an intake aperture. The intake aperture is preferably separated from the intake opening to the first fan and is preferably slightly smaller than the intake openings to the first fan. This will cause air entering the housing to accelerate.

Abstract: Improved acid copper electroplating bath compositions are disclosed. The improved bath solutions contain at least one of a carrier; a water-soluble, mercapto-containing organic brightener; and a leveler which comprises an organic compound containing single or multiply charged centers in acidic bath solution. These electroplating bath compositions are used to copper plate advanced interconnects on semiconductor devices.

Abstract: The present invention provides for methods and compositions for gas separation and purification utilizing a metallo-organic polymer adsorbent in processes for separating carbon dioxide, water, nitrogen oxides and hydrocarbons from gas streams.

Abstract: The present invention provides for novel solid state O2-selective metal complex-based adsorbents and their utility for separating oxygen from a gas stream. In particular, the invention provides for an adsorption complex which contains four-coordinate O2-selective metal complexes including oligomeric/polymeric metal complexes, and organic base-containing polymers supported on porous materials.

Abstract: A method of fabricating an integrated circuit package for ball grid arrays, comprising the steps of: laminating layers of fiberglass prepreg and copper foil to a copper plate in order to create a three-layer laminated carrier; patterning and etching contact pads for input/output and a power/ground ring; applying a solder mask and plating up the contact pads and the ring with a wire bondable metal surface; forming window openings for receiving semiconductor dies; attaching the dies within the windows, wire bonding the dies to the contact pads and the ring, encapsulating the dies, attaching solder balls to the contact pads to create finished packages and singulating the finished packages into individual packages; and attaching the copper plate portion of each of the individual packages to copper plate heat spreader.

Abstract: A method of fabricating an integrated circuit package for ball grid arrays, comprising the steps of: laminating layers of fiberglass prepreg and copper foil to a copper plate in order to create a three-layer laminated carrier; patterning and etching contact pads for input/output and a power/ground ring; applying a solder mask and plating up the contact pads and the ring with a wire bondable metal surface; forming window openings for receiving semiconductor dies; attaching the dies within the windows, wire bonding the dies to the contact pads and the ring, encapsulating the dies, attaching solder balls to the contact pads to create finished packages and singulating the finished packages into individual packages; and attaching the copper plate portion of each of the individual packages to copper plate heat spreader.