Abstract: The present disclosure discloses a scanning method and apparatus, a storage medium, and a computer device. The method includes: obtaining plain film information of a target scanning object, and determining a target bed height based on the plain film information; adjusting the plain film information based on the target bed height to obtain target plain film information; and performing a subsequent operation based on the target plain film information. The present disclosure helps to quickly determine the target bed height, adjust the plain film information based on the target bed height, and perform the subsequent operation based on adjusted plain film information. Thus, a quality of a scanned image is improved while an adjustment efficiency is increased, thereby greatly improving user experience.

Abstract: Disclosed herein are a pharmaceutical composition and a disease therapy method. The pharmaceutical composition relates to an artificial chimeric antigen receptor (CAR). Specifically, the pharmaceutical composition includes a CAR protein that is highly specific to CD19 antigen, a vector that is capable of inducing a cell to generate the certain CAR 19 protein and a population of a modified mammal cell including the CAR19 protein, the vector or combination thereof. Furthermore, the artificial CAR19 includes a CD19 antigen-binding fragment, a transmembrane domain, and a signaling domain. The CD19 antigen-binding fragment is a single-chain variable fragment (scFv) having specific amino acid sequences. Additionally, the method relates to a cancer therapy by using said modified mammal cells. Furthermore, the method includes the steps of purifying a population of autologous cells, modifying the population of autologous cells with an artificial CAR, and administrating the modified autologous cells.

Abstract: Multispecific antigen-binding molecule capable of binding to multiple different antigens, but do not non-specifically crosslink two or more immune cells such as T cells are provided. Methods for producing or enriching a preferred structural form of such multispecific antibody protein, and method for eliminating disulfide heterogeneity of such multispecific antibody proteins are provided. In addition, conformation-specific antibodies that specifically recognize the preferred form of multispecific antibody proteins, and use of the conformation-specific antibodies are provided.

Abstract: A lens module includes a diffractive optical element, a lens, and a plurality of positioning elements, the diffractive optical element and the lens are matched and positively held together. First positioning grooves are defined in the diffractive optical element, and corresponding second positioning grooves are defined in the lens which is stacked on the diffractive optical element. Each positioning element is fixed in and entirely within a first positioning groove and a second positioning groove to fix and hold the diffractive optical element and the lens together.

Abstract: A lens module includes a diffractive optical element, a lens, and a plurality of positioning elements, the diffractive optical element and the lens are matched and positively held together. First positioning grooves are defined in the diffractive optical element, and corresponding second positioning grooves are defined in the lens which is stacked on the diffractive optical element. Each positioning element is fixed in and entirely within a first positioning groove and a second positioning groove to fix and hold the diffractive optical element and the lens together.

Abstract: Semiconductor device and formation method are provided. The method includes providing a substrate, a first fin and a second fin on the substrate, an isolation structure covering a portion of sidewalls of the first and second fins, a gate structure across the first fin or the second fin, a first doped source/drain region in the first fin, a second doped source/drain region in the second fin, and an interlayer dielectric layer on the isolation structure, the first and second fins, and the gate structure. A first through hole is formed in the interlayer dielectric layer, exposing the first doped source/drain region or the second doped source/drain region. A second through hole is formed in the interlayer dielectric layer on the isolation structure to connect to the first through hole. A first plug is formed in the first through hole and a second plug is formed in the second through hole.

Abstract: Disclosed herein provides a pharmaceutical composition and a disease therapy method. The pharmaceutical composition relates to an artificial chimeric antigen receptor (CAR). Specifically, the pharmaceutical composition includes a CAR protein that is highly specific to CD19 antigen, a vector that is capable of inducing a cell to generate the certain CAR 19 protein and a population of a modified mammal cell including the CAR19 protein, the vector or combination thereof. Furthermore, the artificial CAR19 includes a CD19 antigen-binding fragment, a transmembrane domain, and a signaling domain. The CD19 antigen-binding fragment is a single-chain variable fragment (scFv) having specific amino acid sequences. Additionally, the method relates to a cancer therapy by using said modified mammal cells. Furthermore, the method includes the steps of purifying a population of autologous cells, modifying the population of autologous cells with an artificial CAR, and administrating the modified autologous cells.

Abstract: A method for intelligent inspections applicable in an electronic device scans a two-dimensional code, a scanned result including a first location information associated with the two-dimensional code. Next, the method for intelligent inspections transmits the scanned result to an inspection server to trigger the inspection server to return a command for a second location information of the electronic device. The second location information of the electronic device is given according to the command for the second location information of the electronic device. The second location information of the electronic device is transmitted to the inspection server. A related method for intelligent inspections applicable in an inspection server, and an electronic device using the method are also disclosed.

Abstract: Methods, devices and a machine-readable storage medium for denoising a Computed Tomography (CT) image are provided. In one aspect, a method of denoising a CT image includes: generating an original CT image according to raw data which is obtained by scanning a subject, where a pixel count of the original CT image is greater than a preset target pixel count; obtaining a denoised image by denoising the original CT image; and obtaining a target image as a CT image of the subject by compressing the denoised image to the preset target pixel count based on an interpolation algorithm.

Abstract: A method and a device for processing metal artifacts in a CT image are provided. In an example, the method includes: a first image is obtained before a metal probe is intervened; second raw data and a second image corresponding to the second raw data are obtained after the metal probe is intervened; a third image of a metal region in the second image is obtained; channels corresponding to the metal region are determined; CT values of the metal region in the second image are set to a preset value to obtain a model image and model raw data corresponding to the model image; data at the channels in the second raw data is replaced with data at the channels in the model raw data to obtain a replaced second raw data; and based on the replaced second raw data and the third image, a target image is obtained.

Abstract: Semiconductor device and formation method are provided. The method includes providing a substrate, a first fin and a second fin on the substrate, an isolation structure covering a portion of sidewalls of the first and second fins, a gate structure across the first fin or the second fin, a first doped source/drain region in the first fin, a second doped source/drain region in the second fin, and an interlayer dielectric layer on the isolation structure, the first and second fins, and the gate structure. A first through hole is formed in the interlayer dielectric layer, exposing the first doped source/drain region or the second doped source/drain region. A second through hole is formed in the interlayer dielectric layer on the isolation structure to connect to the first through hole. A first plug is formed in the first through hole and a second plug is formed in the second through hole.

Abstract: A method of selecting a slice configuration of a medical imaging apparatus is provided. The method includes: picking out two or more candidate slice configurations from available slice configurations of the medical imaging apparatus; determining a scan dose corresponding to each of the two or more candidate slice configurations; and selecting a candidate slice configuration corresponding to a minimum scan dose as a target slice configuration, where the target slice configuration is used for a current scan protocol.

Abstract: The disclosure includes: judging whether a center line of an object to be scanned is deviated from a rotation axis of a gantry of a CT scanning device; determining a first distance by which the center line of the object to be scanned is deviated from the rotation axis in a case that the center line of the object to be scanned is deviated from the rotation axis; determining according to the first distance a second distance by which the shape filter is to be translated in each projection angle; and controlling the shape filter to make it translate by the second distance in each corresponding projection angle.

Abstract: A method for optimizing CT scanning parameter is disclosed. A target group may be generated from a plurality of reference information samples. Each of the reference information samples may include subject information, information indicating a scanning protocol, one or more scanning parameter values and information indicating reconstructed image quality; the target group can consist of one or more reference information samples with the same subject information and the same scanning protocol. A scanning parameter optimization may be performed according to reconstructed image qualities and scanning parameter values of reference information samples in the target group, so as to acquire a target scanning parameter value of the target group. And according to the target scanning parameter value, a reference X-ray irradiation dose corresponding to the scanning protocol and the subject information of the target group may be determined.

Abstract: Methods of reconstructing a CT image and CT devices are provided in examples of the present disclosure. In one aspect, scanning parameters for a CT device is obtained to perform a scan on a subject, a target reference detector is determined from the reference detectors according to the scanning parameters; the scan is performed on the subject according to the scanning parameters to obtain detection data outputted by the detector and reference detection data outputted by the target reference detector; energy data of the original X-rays emitted by the bulb tube with the scanning parameters is determined according to the reference detection data outputted by the target reference detector; the detection data outputted by the detector is corrected based on the energy data of the original X-rays to obtain scanning data; and the CT image of the subject is reconstructed by performing image reconstruction based on the scanning data.

Abstract: A method and a device for processing metal artifacts in a CT image are provided. In an example, the method includes: a first image is obtained before a metal probe is intervened; second raw data and a second image corresponding to the second raw data are obtained after the metal probe is intervened; a third image of a metal region in the second image is obtained; channels corresponding to the metal region are determined; CT values of the metal region in the second image are set to a preset value to obtain a model image and model raw data corresponding to the model image; data at the channels in the second raw data is replaced with data at the channels in the model raw data to obtain a replaced second raw data; and based on the replaced second raw data and the third image, a target image is obtained.

Abstract: Methods, devices and a machine-readable storage medium for denoising a Computed Tomography (CT) image are provided. In one aspect, a method of denoising a CT image includes: generating an original CT image according to raw data which is obtained by scanning a subject, where a pixel count of the original CT image is greater than a preset target pixel count; obtaining a denoised image by denoising the original CT image; and obtaining a target image as a CT image of the subject by compressing the denoised image to the preset target pixel count based on an interpolation algorithm.

Abstract: A method and device for X-ray scanning based on dose, comprising: receiving an X-ray dose for scanning set for a region of a subject to be scanned, selecting a scanning and reconstructing technology combination according to said pre-set X-ray dose for scanning wherein the demanded X-ray dose of the selected scanning and reconstructing technology combination satisfies said pre-set X-ray dose for scanning, and scanning said region and implementing a reconstruction accordingly with the selected scanning and reconstructing technology combination to obtain a resultant scanning image.

Abstract: Methods, devices, and apparatus, including computer programs encoded on a computer storage medium for reconstructing an image are provided. An example method includes: acquiring Computed Tomography (CT) projection data of a subject, determining an image cutoff frequency Fimg according to a CT image matrix size for reconstructing a CT image and an imaging field of view size, obtaining a convolution kernel and a cutoff frequency Fker of the convolution kernel, using the convolution kernel as a reconstruction convolution kernel when Fker<Fimg; adjusting Fker to a product of a preset value k and Fimg and truncating the convolution kernel to obtain a portion of the convolution kernel having a cutoff frequency no more than the adjusted Fker as the reconstruction convolution kernel when Fker?Fimg, and reconstruct the CT image with the CT projection data and the reconstruction convolution kernel by using a convolution back-projection algorithm.

Abstract: A method and apparatus for selecting high and low energy scanning voltages for a dual energy CT scanner are provided. The method may comprise: setting a criterion of selection for selecting high and low energy scanning voltages; generating combinations of high and low energy scanning voltages according to all scanning voltages supported by a dual energy CT scanner, wherein each of the combinations may comprise a high energy scanning voltage and a low energy scanning voltage; and selecting a combination of high and low energy scanning voltages from the generated combinations of high and low energy scanning voltages based on the criterion of selection.