Abstract: Disclosed in the present invention is a compound as represented by formula (IA) or formula (IC) or a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof. The definition of each group in the formula is shown in the description for details. Further disclosed are a pharmaceutical composition containing the compound and the use thereof in the preparation of a drug for preventing and/or treating diseases or conditions related to HPK1 activity.

Abstract: An atomizing device includes a housing, an end lid and a cover. The end lid is disposed at an end of the housing, and is hermitically connected with the housing. The cover is disposed to cover around the end lid. A first conducting groove is disposed to extend circumferentially at a selective one of an outer wall of the end lid and an inner wall of the cover. A second conducting groove is spatially communicated with the first conducting groove, and an included angle is formed between the first conducting groove and the second conducting groove. A sliding piece is disposed at the rest of the outer wall of the end lid and the inner wall of the cover to mate with the first conducting groove and the second conducting groove. The sliding piece is disposed to move in the first conducting groove and the second conducting groove.

Abstract: A compound having HPK1 inhibitory activity as shown in formula (IA) or (IC), and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and use of same in preparation of a drug for preventing and/or treating diseases or conditions associated with HPK1 activity.

Abstract: The present disclosure discloses a recombinant varicella-zoster virus (VZV) vaccine, including a fusion protein formed by an amino acid sequence of an extracellular domain of a recombinant glycoprotein gE of a live attenuated VZV strain (OKA strain) gene and an Fc fragment of human immunoglobulin. The present disclosure further provides preparation and use of the fusion protein, a corresponding recombinant gene, a eukaryotic expression vector, etc. The fusion protein of the present disclosure has prominent immunogenicity and can induce the high-level expression of neutralizing antibodies in serum.

Abstract: Provided are a fused tricyclic compound having the structure shown in formula (I), a pharmaceutical composition thereof, and a use thereof. The fused tricyclic compound serves as a selective inhibitor of KRAS mutation, and has high activity, good selectivity. and reduced toxic side effects.

Abstract: An aerosol-shielding endoscopy mouthpiece (AeroFree mouthpiece) is disclosed. The aerosol-shielding endoscopy mouthpiece includes a bite block part through which the endoscope passes and a mouth and nose-shielding part. Besides allowing for safe passage of the endoscope and respiration of the examinee, the bite block part includes a cover which is configured to mitigate splashing of aerosol and saliva through the orifice for endoscope passage during the endoscopic procedure. The mouth and nose-shielding part contains the bodily fluids and aerosols from the examinee's mouth and nose and reduces the risk of contamination at the time of removal and disposal.

Abstract: The present disclosure discloses a recombinant varicella-zoster virus (VZV) vaccine, including a fusion protein formed by an amino acid sequence of an extracellular domain of a recombinant glycoprotein gE of a live attenuated VZV strain (OKA strain) gene and an Fc fragment of human immunoglobulin. The present disclosure further provides preparation and use of the fusion protein, a corresponding recombinant gene, a eukaryotic expression vector, etc. The fusion protein of the present disclosure has prominent immunogenicity and can induce the high-level expression of neutralizing antibodies in serum.

Abstract: An atomizing device includes a housing, an end lid and a cover. The end lid is disposed at an end of the housing, and is hermitically connected with the housing. The cover is disposed to cover around the end lid. A first conducting groove is disposed to extend circumferentially at a selective one of an outer wall of the end lid and an inner wall of the cover. A second conducting groove is spatially communicated with the first conducting groove, and an included angle is formed between the first conducting groove and the second conducting groove. A sliding piece is disposed at the rest of the outer wall of the end lid and the inner wall of the cover to mate with the first conducting groove and the second conducting groove. The sliding piece is disposed to move in the first conducting groove and the second conducting groove.

Abstract: An oxaazaquinazolin-7(8H)-ketone compound with a selective inhibition effect on KRAS gene mutation and pharmaceutically acceptable salts thereof, stereoisomers, solvent compounds or prodrugs (as shown in formula I or formula II, see the details of the definition to each group in the formulas in the specification), as well as the pharmaceutical composition containing the compound, and the application thereof in preparation of cancer medicine.

Abstract: A phosphorus-based calcification inhibitor (“inhibitor”) configured to prevent calcification of anaerobic granular sludge.

Abstract: A biosensor and a biological detection method are provided. The biosensor includes a substrate, a plurality of first and second electrodes in a strip shape, a material layer and a capture antibody. The substrate has a sampling region and a measuring region connected to the sampling region. The first and second electrodes are disposed on the substrate in the measuring region, and the first and second electrodes are arranged alternately with each other, wherein the first electrodes are connected in parallel with each other, and the second electrodes are connected in parallel with each other.

Abstract: The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.

Abstract: The present invention belongs to the technical field of wastewater treatment, and particularly relates to a method for pre-conditioning high-calcium wastewater by calcification blocking, and a device for implementing the method. The method for treating high-calcium wastewater by calcification blocking includes mixing high-calcium wastewater, an alkalizing agent and a chelating agent, and carrying out alkalizing conditioning pretreatment under a condition of stirring by bubbling of a biogas, so as to obtain pre-conditioned wastewater. The pre-conditioned wastewater is mixed with anaerobic granular sludge, and an anaerobic reaction is performed in a high hydraulic shear flow field formed by the biogas, so as to generate the biogas and calcium scale. A part of the biogas for the stirring is refluxed by bubbling of the biogas and the rest of the biogas is refluxed for forming the high hydraulic shear flow field.

Abstract: Embodiments of the present invention pertain to a composite decalcification agent of calcified anaerobic granular sludge and a decalcification regeneration process.

Abstract: A phosphorus-based calcification inhibitor (“inhibitor”) configured to prevent calcification of anaerobic granular sludge.

Abstract: Embodiments of the present invention pertain to a composite decalcification agent of calcified anaerobic granular sludge and a decalcification regeneration process.

Abstract: A ubiquitous auto calibration device is provided, which includes microcontroller unit, flex bus, image receiver image processing module, and an image output unit. The microcontroller unit is provided for receiving the electronic signal and performing a self-adjusting process to the electronic signal. The flex bus is connected with the microcontroller unit, and is provided for transmitting the electronic signal to the image processing module after performing the self-adjusting process. The image receiver is provided for receiving the image signal from the image receiving interface. The image processing module is provided for performing an image calibration process to the image signal, so that the image signal can obey the color temperature standard, Gamma value, uniformity and color gamut standards when the panel outputs the image signal.

Abstract: A ubiquitous auto calibration device is provided, which includes microcontroller unit, flex bus, image receiver image processing module, and an image output unit. The microcontroller unit is provided for receiving the electronic signal and performing a self-adjusting process to the electronic signal. The flex bus is connected with the microcontroller unit, and is provided for transmitting the electronic signal to the image processing module after performing the self-adjusting process. The image receiver is provided for receiving the image signal from the image receiving interface. The image processing module is provided for performing an image calibration process to the image signal, so that the image signal can obey the color temperature standard, Gamma value, uniformity and color gamut standards when the panel outputs the image signal.