Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: The present invention relates to an article comprising a substrate at least partially coated with a composition comprising solid in the form of aggregate and (per) fluoropolyether polymer. The invented article shows excellent performance on amphiphobicity and transparency.

Abstract: A slurry suspension is provided, which comprises (a) carbonaceous material particles having an average diameter D50 comprised between 0.1 ?m and 200 ?m; (b) an organic compound comprising at least one amine group; and (c) an organic phase.

Abstract: A slurry suspension is provided, which comprises (a) carbonaceous material particles having an average diameter D50 comprised between 0.1 ?m and 200 ?m; (b) an organic compound comprising at least one amine group; and (c) an organic phase.

Abstract: A glass manufacturing apparatus may be configured to facilitate a process of separating a glass ribbon along a separation path extending across a width of the glass ribbon. In one example, the glass manufacturing apparatus comprises at least one anvil-side vacuum port defined by an elongated nose and an elongated anvil member. The anvil-side vacuum port is configured to remove glass debris during the process of separating the glass ribbon. In another example, the glass manufacturing apparatus comprises a scoring device and a score-side vacuum port configured to remove glass debris generated during the process of separating the glass ribbon.

Abstract: The present disclosure is directed to novel methods of treating type-1 or type-2 diabetes by inactivating TLR2 and TLR4 genes together in cells capable of producing insulin and/or regenerating ? cells, and providing the cells to a subject in need thereof.

Abstract: A slurry suspension is provided, which comprises (a) carbonaceous material particles having an average diameter D50 comprised between 0.1 ?m and 200 ?m; (b) an organic compound comprising at least one amine group; and (c) an organic phase.

Abstract: Disclosed is a liquid biofuel comprising carbonaceous material particles having a D50 ranging from 0.1 ?m to 200 ?m suspended in a liquid biodiesel composition.

Abstract: A slurry suspension comprises: a) carbonaceous material particles having an average diameter D50 comprised between 0.1 ?m and 200 ?m; b) a non-ionic surfactant; c) an aqueous phase; and d) an organic phase.

Abstract: The present disclosure is directed to novel methods of treating type-1 or type-2 diabetes by inactivating TLR2 and TLR4 genes together in cells capable of producing insulin and/or regenerating ? cells, and providing the cells to a subject in need thereof.

Abstract: Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer T (NKT) cells attenuate inflammation in adipose tissue and improves systemic glucose homeostasis in mice at different stages of obesity. Accordingly, the present invention provides methods of treating type-2 diabetes or those at risk for type-2 diabetes using activators of adipose-resident NKT cells. Such activators include particular glycolipids (e.g., a-galactosylceramide and its analogs other than sulfated analogs) and cytokines that promote M2 macrophage polarization. The invention also includes methods to screen for activators of adipose-resident NKT cells.

Abstract: Testing stacked devices. In accordance with a first method embodiment, a primary circuit assembly is accessed from a first circuit assembly carrier. The primary circuit assembly is placed into a test fixture. A secondary circuit assembly is accessed from a second circuit assembly carrier. The secondary circuit assembly is placed into the test fixture on top of the primary circuit assembly. The primary circuit assembly is tested in conjunction with said secondary circuit assembly while coupled together.

Abstract: A SMT tape includes a carrier tape, a number of separation pads, a number of workpieces, and a package tape. The carrier tape includes a package surface and defines a number of receiving grooves in the package surface and arranged along a length direction of the carrier tape. The separation pads are received in the receiving grooves and fixed to bottom surfaces of the receiving grooves respectively. Each separation pad includes a separation surface opposite to a bottom surface of the corresponding receiving groove and a number of protrusions protruding up from the separation surface. The workpieces are respectively received in the receiving grooves. Each workpiece includes a main body and an adhesive layer positioned between the corresponding separation pad and the main body. The package tape is adhered to the package surface and seals the receiving grooves.

Abstract: Testing stacked devices. In accordance with a first method embodiment, a primary circuit assembly is accessed from a first circuit assembly carrier. The primary circuit assembly is placed into a test fixture. A secondary circuit assembly is accessed from a second circuit assembly carrier. The secondary circuit assembly is placed into the test fixture on top of the primary circuit assembly. The primary circuit assembly is tested in conjunction with said secondary circuit assembly while coupled together.

Abstract: Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer T (NKT) cells attenuate inflammation in adipose tissue and improves systemic glucose homeostasis in mice at different stages of obesity. Accordingly, the present invention provides methods of treating type-2 diabetes or those at risk for type-2 diabetes using activators of adipose-resident NKT cells. Such activators include particular glycolipids (e.g., a-galactosyl-ceramide and its analogs other than sulfated analogs) and cytokines that promote M2 macrophage polarization. The invention also includes methods to screen for activators of adipose-resident NKT cells.

Abstract: A SMT tape includes a carrier tape, a number of separation pads, a number of workpieces, and a package tape. The carrier tape includes a package surface and defines a number of receiving grooves in the package surface and arranged along a length direction of the carrier tape. The separation pads are received in the receiving grooves and fixed to bottom surfaces of the receiving grooves respectively. Each separation pad includes a separation surface opposite to a bottom surface of the corresponding receiving groove and a number of protrusions protruding up from the separation surface. The workpieces are respectively received in the receiving grooves. Each workpiece includes a main body and an adhesive layer positioned between the corresponding separation pad and the main body. The package tape is adhered to the package surface and seals the receiving grooves.

Abstract: The present invention relates to a method for producing a coating based on two organic semi-conducting compounds CP and CN, respectively of type P and of type N, CN being immiscible with compound CP in the coating produced, and wherein: (A) a solution is deposited on the surface of the support, comprising compounds CP and CN in a solvent medium S capable of solvating compounds CP and CN without chemically reacting therewith, said solvent S being formed by a mixture of: a first fraction formed by a solvent or a mixture of solvents S1 capable of solvating both compounds CP or CN; and a second fraction miscible with the first fraction consisting of a solvent or a mixture of solvents S2 with a higher boiling point than that of the solvent or mixture of solvents S1 and which is capable of solvating one of the compounds CP or CN but not the other one; and (B) the solvent S present in the thereby produced deposit is removed by evaporation.

Abstract: The present invention is directed to a process for the preparation of an aqueous dispersion of coacervates having a core-shell structure, the core (a) being an inorganic particle being anionic or cationic and the shell (b) being a copolymer wherein said copolymer comprises at least two parts, A and B, part A being cationic if particle (a) is anionic, and anionic if particle (a) is cationic, and part B being neutral in pH conditions of said dispersion. More particularly, the invention is directed to treating compositions comprising that aqueous dispersion of coacervates delivering antifouling, water sheeting, antisoiling, anti-adhesion, adhesion, anti-deposition, and/or anti-UV properties onto all kinds of surfaces.

Abstract: Disclosed herein are methods for identifying agents capable of affecting the expression, posttranslational modification, and/or an activity of TRB3, for example, in adipose tissue and/or adipocytes. Such agents are useful, for example, to mobilize fat stores and as prospective obesity therapeutics.

Abstract: A surface modified substrate includes a substrate having a surface, a layer of nanoscale inorganic oxide particles disposed on at least a portion of the surface of the substrate, said layer of nanoscale inorganic oxide particles comprising sites bearing an electric charge of a first polarity, and a monolayer of a polymer disposed on a least a portion of the layer of nanoscale inorganic oxide particles, said monolayer of polymer comprising sites bearing an electric charge of a second polarity, wherein the second polarity is the opposite of the first polarity.