Patents by Inventor Ling Tong
Ling Tong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12329396Abstract: Kidney stone removal system is disclosed having components including a handle mechanism, a nozzle tip, and a guiding device. The handle mechanism employs a trigger that enables control of irrigation and vacuum/suction. Depression of a trigger in the trigger mechanism conveys status of vacuum/suction and irrigation to a user by providing increased resistance at different points of depression. When the trigger is in a home (undepressed) position, irrigation and vacuum/suction are turned off. When the trigger is in a fully depressed position, irrigation and vacuum/suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum/suction remains turned off. The nozzle includes one or more irrigation ports positioned at a distal end of the nozzle and having an irrigation port departure angle of 30 to 60 degrees for directing irrigation fluid forward and laterally from the distal end of the nozzle.Type: GrantFiled: March 1, 2023Date of Patent: June 17, 2025Assignee: CALYXO, INC.Inventors: Ling Tong, Calvin Lam, Kejin Wang, Joseph Catanese, III, Jee Shin, Alex Lim, Brian Y. Tachibana, Matthew Yurek, Caralin Riva Adair, Andrew J. Hudson, Andrew Johnston, Eddie Gonzalez, Ailee Pham
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Patent number: 12329399Abstract: Kidney stone removal system is disclosed having components including a handle mechanism, a nozzle tip, and a guiding device. The handle mechanism employs a trigger that enables control of irrigation and vacuum/suction. Depression of a trigger in the trigger mechanism conveys status of vacuum/suction and irrigation to a user by providing increased resistance at different points of depression. When the trigger is in a home (undepressed) position, irrigation and vacuum/suction are turned off. When the trigger is in a fully depressed position, irrigation and vacuum/suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum/suction remains turned off. The nozzle includes one or more irrigation ports positioned at a distal end of the nozzle and having an irrigation port departure angle of 30 to 60 degrees for directing irrigation fluid forward and laterally from the distal end of the nozzle.Type: GrantFiled: September 6, 2024Date of Patent: June 17, 2025Assignee: CALYXO, INC.Inventors: Ling Tong, Calvin Lam, Kejin Wang, Joseph Catanese, III, Jee Shin, Alex Lim, Brian Y. Tachibana, Matthew Yurek, Caralin Riva Adair, Andrew J. Hudson, Andrew Johnston, Eddie Gonzalez, Ailee Pham
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Publication number: 20250191189Abstract: According to an aspect, there is provided an apparatus for use in analysing ultrasound image data of a subject, the apparatus comprising a memory comprising instruction data representing a set of instructions; and a processor configured to communicate with the memory and to execute the set of instructions, wherein the set of instructions, when executed by the processor, cause the processor to: obtain contrast-enhanced ultrasound image data comprising a temporal sequence of frames; estimate at least one time point corresponding to at least one event; select a sample of frames from the plurality of frames based on the at least one estimated time point; and classify the sample of frames to derive a feature.Type: ApplicationFiled: August 24, 2022Publication date: June 12, 2025Inventors: Zhouye Chen, Qizhong Lin, Xiaowei Hong, Ling Tong, Junping Deng, Jingping Xu, Lin Li, Ningning Zhao, Jianan Wang, Qiao Hua, Thanasis Loupas
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Publication number: 20250171467Abstract: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).Type: ApplicationFiled: March 8, 2023Publication date: May 29, 2025Applicant: Merck Sharp & Dohme LLCInventors: Anthony J. Roecker, Ling Tong
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Patent number: 12279939Abstract: A wearable article wherein least some of the elastic bodies may be arranged in at least 2 sets of a concentrated array defined as meeting: a) one concentrated array is formed by 2-4 elastic bodies; b) each elastic body within one concentrated array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific concentrated array disposed in an extra-interval between at least one neighboring elastic body outside the specific concentrated array of less than 8 mm. The entirety of the length of the belt side edge of the front belt may be seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may each divided into 4 zones wherein at least 2 concentrated arrays are disposed on the front proximal tummy zone or the back distal tummy zone.Type: GrantFiled: March 24, 2023Date of Patent: April 22, 2025Assignee: The Procter & Gamble CompanyInventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
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Patent number: 12279937Abstract: Disclosed is a wearable article comprising a main body and a ring-like elastic belt comprising a front belt and a back belt. At least some of the elastic bodies may be arranged in an array, the array defined as meeting: a) one array is formed by 2-10 elastic bodies; b) each elastic body within one array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific array disposed in an extra-interval between at least one neighboring elastic bodies outside the specific array of greater than the inner-interval. Further, the front belt may comprise at least 5 arrays.Type: GrantFiled: March 24, 2023Date of Patent: April 22, 2025Assignee: The Procter & Gamble CompanyInventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
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Patent number: 12274605Abstract: The present disclosure relates to wearable articles having an elastic belt having arrays of elastic bodies.Type: GrantFiled: March 24, 2023Date of Patent: April 15, 2025Assignee: The Procter & Gamble CompanyInventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
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Patent number: 12263034Abstract: An ultrasonic method for quantifying the nonlinear shear wave elasticity of a medium, the method comprising the following steps: A1.—collecting a temporal succession of shear wave elasticity data from the medium, A2.—applying, to the medium, a deformation that successively changes according to a predetermined sequence of deformations, during the collection of the shear waves, A3.—observing the actual evolution of deformation, and B.—quantifying the nonlinear elasticity of the medium depending on the temporal succession of data and the evolution of deformation.Type: GrantFiled: December 10, 2020Date of Patent: April 1, 2025Assignee: SUPERSONIC IMAGINEInventors: Bo Zhang, Ling Tong, Cyril Dolgoff, Hélène Sportouche, Jean-Pierre Henry
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Patent number: 12256989Abstract: A catheter assembly is provided having a working lumen and a guide. The guide is configured to position a fragmentizing device within the working lumen. The guide is configured to prevent or minimize any unintended movement of a distal section of the fragmentizing device within the working lumen when the distal section of the fragmentizing device is positioned at a distal end of the working lumen.Type: GrantFiled: September 6, 2024Date of Patent: March 25, 2025Assignee: CALYXO, INC.Inventors: Matthew Yurek, Ling Tong, Brian Y. Tachibana, Thomas R. Jenkins, Calvin Lam, Ailee Pham, Kejin Wang, Joseph Catanese, III, Jee Shin, Caralin Riva Adair, Andrew J. Hudson
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Publication number: 20250078277Abstract: A system for providing contrast enhanced ultrasound (CEUS) images is described. The CEUS system includes an ultrasound probe adapted to provide the ultrasound images; a processor configured to determine out-of-plane frames of the ultrasound images, and remove the out-of-plane frames from the ultrasound images based on a criterion to provide an optimized set of frames; and a display in communication with the processor and configured to display the optimized set of frames.Type: ApplicationFiled: August 27, 2024Publication date: March 6, 2025Inventors: Qi Zhong Lin, Zhouye Chen, Jianan Wang, Jingping Xu, Ling Tong, Jin Ning Chen, Xiang Hui Bai, Thanasis Loupas
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Publication number: 20250032328Abstract: The present disclosure relates to front and back waist belt assemblies for absorbent articles. In some configurations, an absorbent article may include an absorbent chassis. First and second belts may be connected with opposing end regions of the chassis. At least one of the first belt and the second belt may comprise: an elastic material positioned between and connected with a first substrate and a second substrate. A panel layer extending longitudinally from a first lateral edge to a second lateral edge may be connected with at least one of the first substrate and the second substrate. The panel layer and/or the first and/or second substrate of the first and/or second belts may include features that differ along a width and/or length of the belts. Such features may include belt tensioning, rugosities, bonding patterns, and/or aperture arrangements.Type: ApplicationFiled: October 11, 2024Publication date: January 30, 2025Inventors: Ling TONG, Donald Carroll ROE
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Patent number: 12209145Abstract: Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.Type: GrantFiled: June 30, 2022Date of Patent: January 28, 2025Assignee: MERCK SHARP & DOHME LLCInventors: Harold B. Wood, Hubert B. Josien, Thomas Joseph Tucker, Angela Dawn Kerekes, Ling Tong, Abbas M. Walji, Anilkumar G. Nair, Fa-Xiang Ding, Elisabetta Bianchi, Danila Branca, Chengwei Wu, Yusheng Xiong, Sookhee Nicole Ha, Jian Liu, Sobhana Babu Boga
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Publication number: 20250026762Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).Type: ApplicationFiled: November 28, 2022Publication date: January 23, 2025Applicant: Merck Sharp & Dohme LLCInventors: Mark E. Fraley, Tao Liang, H. Marie Loughran, Anthony J. Roecker, Kathy M. Schirripa, Ling Tong, Ashwin U. Rao
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Patent number: 12199509Abstract: The present application relates to a bidirectional digital switching power amplifier based on a magnetic suspension drive platform and its multi-step current predictive control method. The control method includes the following steps: establishing a prediction model of a bidirectional digital switching power amplifier; introducing a feedback correction term for a closed loop prediction; calculating an optimal modulation duty cycle through a value function; generating, according to the obtained modulation duty cycle, four PWM drive signals by a pulse width modulation module to control four switch tubes respectively to achieve current prediction control. The present application effectively improves the system control accuracy with small steady-state error, small on-line computation amount, simple algorithm, easy digital realization, and good practical value and application prospect.Type: GrantFiled: May 19, 2021Date of Patent: January 14, 2025Assignee: SHENYANG UNIVERSITY OF TECHNOLOGYInventors: Feng Sun, Fangchao Xu, Junjie Jin, Gaojie Song, Li Chen, Ming Zhang, Ling Tong, Qiang Li, Xiaoyou Zhang
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Publication number: 20240423715Abstract: A catheter assembly is provided having a working lumen and a guide. The guide is configured to position a fragmentizing device within the working lumen. The guide is configured to prevent or minimize any unintended movement of a distal section of the fragmentizing device within the working lumen when the distal section of the fragmentizing device is positioned at a distal end of the working lumen.Type: ApplicationFiled: September 6, 2024Publication date: December 26, 2024Inventors: Matthew YUREK, Ling TONG, Brian Y. TACHIBANA, Thomas R. JENKINS, Calvin LAM, Ailee PHAM, Kejin WANG, Joseph CATANESE, III, Jee SHIN, Caralin Riva ADAIR, Andrew J. HUDSON
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Publication number: 20240423716Abstract: Kidney stone removal system is disclosed having components including a handle mechanism, a nozzle tip, and a guiding device. The handle mechanism employs a trigger that enables control of irrigation and vacuum/suction. Depression of a trigger in the trigger mechanism conveys status of vacuum/suction and irrigation to a user by providing increased resistance at different points of depression. When the trigger is in a home (undepressed) position, irrigation and vacuum/suction are turned off. When the trigger is in a fully depressed position, irrigation and vacuum/suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum/suction remains turned off. The nozzle includes one or more irrigation ports positioned at a distal end of the nozzle and having an irrigation port departure angle of 30 to 60 degrees for directing irrigation fluid forward and laterally from the distal end of the nozzle.Type: ApplicationFiled: September 6, 2024Publication date: December 26, 2024Inventors: Ling TONG, Calvin LAM, Kejin WANG, Joseph CATANESE, III, Jee SHIN, Alex LIM, Brian Y. TACHIBANA, Matthew YUREK, Caralin Riva ADAIR, Andrew J. HUDSON, Andrew JOHNSTON, Eddie GONZALEZ, Ailee PHAM
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Patent number: 12156548Abstract: A wearable article includes a front and back elastic belts, a crotch region, a waist opening, and leg openings. Each elastic belt is a laminate having an inner sheet, an outer sheet, and an elastic member. Elastic adhesive bonding continuously bonds the elastic member for at least about 10 mm in the direction of stretch adjacent the side edges of the belts. A discrete patterned adhesive bonding is applied to at least one of the inner and outer sheets to intermittently bond the inner and outer sheets. The discrete patterned adhesive bonding extends substantially along the transverse direction between the elastic adhesive bonding, and substantially along the longitudinal direction between the distal and proximal edges of the elastic belts. The same adhesive agent provides the elastic adhesive and discrete patterned adhesive bonding. Heat bonds form side seams, and the remainder of the laminate is free of heat bonds.Type: GrantFiled: February 17, 2023Date of Patent: December 3, 2024Assignee: The Procter & Gamble CompanyInventors: Shiqiao Li, Ruizhi Pei, Kaoru Ishihara, Koichi Morimoto, Xuechun Wang, Ling Tong, John Andrew Strasemeier, Vanessa Marie Melendez, Monica Renee Tournoux
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Publication number: 20240350198Abstract: Kidney stone removal system is disclosed having components including a handle mechanism, a nozzle tip, and a guiding device. The handle mechanism employs a trigger that enables control of irrigation and vacuum/suction. Depression of a trigger in the trigger mechanism conveys status of vacuum/suction and irrigation to a user by providing increased resistance at different points of depression. When the trigger is in a home (undepressed) position, irrigation and vacuum/suction are turned off. When the trigger is in a fully depressed position, irrigation and vacuum/suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum/suction remains turned off. The nozzle includes one or more irrigation ports positioned at a distal end of the nozzle and having an irrigation port departure angle of 30 to 60 degrees for directing irrigation fluid forward and laterally from the distal end of the nozzle.Type: ApplicationFiled: June 24, 2024Publication date: October 24, 2024Inventors: Ling TONG, Calvin LAM, Kejin WANG, Joseph CATANESE, III, Jee SHIN, Alex LIM, Brian Y. TACHIBANA, Matthew YUREK, Caralin Riva ADAIR, Andrew J. HUDSON, Andrew JOHNSTON, Eddie GONZALEZ, Ailee PHAM
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Publication number: 20240341848Abstract: A catheter assembly is provided having a working lumen and a guide. The guide is configured to position a fragmentizing device within the working lumen. The guide is configured to prevent or minimize any unintended movement of a distal section of the fragmentizing device within the working lumen when the distal section of the fragmentizing device is positioned at a distal end of the working lumen.Type: ApplicationFiled: June 25, 2024Publication date: October 17, 2024Inventors: Matthew YUREK, Ling Tong, Brian Y. Tachibana, Thomas R. Jenkins, Calvin Lam, Ailee Pham, Kejin Wang, Joseph Catanese, III, Jee Shin, Caralin Riva Adair, Andrew J. Hudson
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Publication number: 20240325687Abstract: A force-limiting access system is provided and includes a distal tip section configured to advance within a body lumen; a shaft coupled with the distal tip section; and a handle coupled with the shaft via an interface. The interface is configured to maintain a positional relationship between the handle and the shaft while the shaft experiences a force less than a threshold force and to allow the handle to move with respect to the shaft when the shaft experiences a force greater than the threshold force.Type: ApplicationFiled: June 11, 2024Publication date: October 3, 2024Inventors: Joseph CATANESE, III, Ling TONG, Matthew YUREK