Patents by Inventor Ling Tong

Ling Tong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10981902
    Abstract: The present invention is directed to 5-(pyridine-3-yl)oxaxole compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: April 20, 2021
    Assignees: Merck Sharp & Dohme Corp., Merck MSD (R&D) China Co., LTD.
    Inventors: Jianming Bao, Timothy J. Henderson, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Meng Na, Michael T. Rudd, David M. Tellers, Ling Tong
  • Patent number: 10973704
    Abstract: Articles of the present disclosure may have a tensile stress of the front proximal tummy zone higher than the tensile stress of any of the front waist zone, the front distal tummy zone, or the front leg zone, and a tensile stress of the back distal tummy zone higher than any of the tensile stress of the back waist zone, the back proximal tummy zone, or the back leg zone.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: April 13, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Koichi Morimoto, Chunmin Cheng, Ling Tong
  • Patent number: 10933056
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: March 2, 2021
    Assignees: Merck Sharp & Dohme Corp., MSD R&D (China) Co. Ltd.
    Inventors: John J. Acton, III, Jianming Bao, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Sandra L. Knowles, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, Michael T. Rudd, Oleg B. Selyutin, David M. Tellers, Ling Tong, Jenny Miu-Chun Wai
  • Publication number: 20210030602
    Abstract: The invention relates to a disposable absorbent pant comprising a central chassis and elasticized front and rear belt. The central chassis comprises an absorbent core with an absorbent layer. The absorbent layer comprises a first and a second longitudinally-oriented elongate channel formed therein.
    Type: Application
    Filed: July 13, 2020
    Publication date: February 4, 2021
    Inventors: Carsten Heinrich KREUZER, Ernesto Gabriel BIANCHI, Bruno Johannes EHRNSPERGER, Ling TONG, Claus Peter STOELZEL
  • Publication number: 20210022411
    Abstract: A wearable article includes a front and back elastic belts, a crotch region, a waist opening, and leg openings. Each elastic belt is a laminate having an inner sheet, an outer sheet, and an elastic member. Elastic adhesive bonding continuously bonds the elastic member for at least about 10 mm in the direction of stretch adjacent the side edges of the belts. A discrete patterned adhesive bonding is applied to at least one of the inner and outer sheets to intermittently bond the inner and outer sheets. The discrete patterned adhesive bonding extends substantially along the transverse direction between the elastic adhesive bonding, and substantially along the longitudinal direction between the distal and proximal edges of the elastic belts. The same adhesive agent provides the elastic adhesive and discrete patterned adhesive bonding. Heat bonds form side seams, and the remainder of the laminate is free of heat bonds.
    Type: Application
    Filed: February 14, 2020
    Publication date: January 28, 2021
    Inventors: Shiqiao LI, Ruizhi PEI, Kaoru ISHIHARA, Koichi MORIMOTO, Xuechun WANG, Ling TONG, John Andrew STRASEMEIER, Vanessa Marie MELENDEZ, Monica Renee TOURNOUX
  • Publication number: 20200390615
    Abstract: The invention relates to a disposable absorbent pant comprising a central chassis and elasticized front and rear belt. The central chassis comprises an absorbent core with an absorbent layer. The absorbent layer comprises a continuous channel formed therein.
    Type: Application
    Filed: July 13, 2020
    Publication date: December 17, 2020
    Inventors: Carsten Heinrich KREUZER, Ernesto Gabriel BIANCHI, Bruno Johannes EHRNSPERGER, Ling TONG, Claus Peter STOELZEL
  • Patent number: 10836775
    Abstract: The present invention is directed to 6,6-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: November 17, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Xiaolei Gao, Sandra L. Knowles, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Ling Tong
  • Publication number: 20200327673
    Abstract: A method for thinning and connection in linear object extraction from an image and including the following steps: 1. extracting direction features using various sliding windows from the binary image obtained of linear objects. 2. decomposing the binary image into several binary image layers according to the direction features. 3. extracting thinned curves and endpoints of each binary image layer by conducting curve fitting on each connected component using coordinate information. 4. connecting the thinned curves by computing spatial distances between the endpoints belonging to different thinned curves, angles between the tangential direction and connected direction vectors of the connected points. Finally, the road network image is constructed by overlaying image layers with the thinned curves.
    Type: Application
    Filed: November 29, 2019
    Publication date: October 15, 2020
    Inventors: Ling Tong, Fanghong Xiao
  • Publication number: 20200261282
    Abstract: Disclosed is a wearable article comprising a front elastic belt, a back elastic belt, a crotch region extending longitudinally between the front elastic belt and the back elastic belt; wherein at least 10% of the longitudinal dimension of the front and back elastic belts from a waist opening is a laminate in active elasticity defining an Upper Gather Region. The Upper Gather Region may have a particular Directional Dispersion Value and a particular Continuity Value according to measurements herein. The laminate may have at least one of the inner sheet and the outer sheet comprising a plurality of deformations aligned in the longitudinal direction.
    Type: Application
    Filed: February 11, 2020
    Publication date: August 20, 2020
    Inventors: Shiqiao LI, Ruizhi PEI, Kaoru ISHIHARA, Koichi MORIMOTO, Xuechun WANG, Ling TONG, John Andrew STRASEMEIER, Vanessa Marie MELENDEZ, Monica Renee TOURNOUX
  • Publication number: 20200260800
    Abstract: A wearable article includes front and back elastic belts, a crotch region, a waist opening, and leg openings. Each elastic belt is a laminate having an inner sheet, an outer sheet, and a an elastic member running in the transverse direction. Elastic bonding continuously bonds the elastic member for at least about 10 mm in the direction of stretch in a region adjacent side edges of the elastic belts, and vertical bonding applied to the inner and/or the outer sheet intermittently bonds the elastic member to said inner and/or outer sheets. At least one of the inner sheet and the outer sheet comprises a plurality of deformations aligned in the longitudinal direction. The article has a Stretch Circumference Force of about 6.5 N or less and a Fit Circumference Force of at least about 3.0 N. The ratio of Stretch Circumference Force/Fit Circumference Force is less than about 1.8.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 20, 2020
    Inventors: Shiqiao LI, Ruizhi PEI, Kaoru ISHIHARA, Koichi MORIMOTO, Xuechun WANG, Ling TONG, John Andrew STRASEMEIER, Vanessa Marie MELENDEZ, Monica Renee TOURNOUX
  • Patent number: 10744044
    Abstract: Disclosed is a wearable article comprising a main body and a ring-like elastic belt comprising a front belt and a back belt, where the entirety of the length of the belt side edge of the front belt may be seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may be each divided into 4 zones, where the tensile stress of the front proximal tummy zone may be higher than the tensile stress of any of the front waist zone, the front distal tummy zone, or the front leg zone, and the tensile stress of the back distal tummy zone may be higher than any of the tensile stress of the back waist zone, the back proximal tummy zone, or the back leg zone.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: August 18, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng, Masaharu Nishikawa
  • Patent number: 10738062
    Abstract: The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A?, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: August 11, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Wensheng Yu, Joseph A. Kozlowski, Ling Tong, Craig A. Coburn, Bin Hu, Bin Zhong, Jinglai Hao, Dahai Wang
  • Publication number: 20200206042
    Abstract: A wearable article wherein least some of the elastic bodies may be arranged in at least 2 sets of a concentrated array defined as meeting: a) one concentrated array is formed by 2-4 elastic bodies; b) each elastic body within one concentrated array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific concentrated array disposed in an extra-interval between at least one neighboring elastic body outside the specific concentrated array of less than 8 mm. The entirety of the length of the belt side edge of the front belt may be seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may each divided into 4 zones wherein at least 2 concentrated arrays are disposed on the front proximal tummy zone or the back distal tummy zone.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
  • Publication number: 20200206041
    Abstract: Disclosed is a wearable article comprising a main body and a ring-like elastic belt comprising a front belt and a back belt. At least some of the elastic bodies may be arranged in an array, the array defined as meeting: a) one array is formed by 2-10 elastic bodies; b) each elastic body within one array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific array disposed in an extra-interval between at least one neighboring elastic bodies outside the specific array of greater than the inner-interval. Further, the front belt may comprise at least 5 arrays.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
  • Publication number: 20200207758
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Application
    Filed: June 22, 2018
    Publication date: July 2, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: John J. ACTON, III, Jianming BAO, Qiaolin DENG, Melissa EGBERTSON, Ronald FERGUSON, II, Xiaolei GAO, Scott Timothy HARRISON, Sandra L. KNOWLES, Chunsing LI, Michael Man-Chu LO, Robert D. MAZZOLA, Jr., Zhaoyang MENG, Meng NA, Michael T. RUDD, Oleg SELYUTIN, David M. TELLERS, Ling TONG, Fengqi ZHANG
  • Publication number: 20200197234
    Abstract: An article with the entirety of the length of the belt side edge of the front belt seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may each be divided into 4 zones extending in the transverse direction and defined by its location from the distal edge to the proximal edge relative to the percentage of the seam length LS where: 0-25% is the waist zone, 25-50% is the distal tummy zone, 50-85% is the proximal tummy zone, and 85-100% is the leg zone. The tensile stress of the front leg zone may be no more than 50% of the tensile stress of the front proximal tummy zone, and the tensile stress of the back leg zone may be no more than 100% of the tensile stress of the back proximal tummy zone.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng, Masaharu Nishikawa
  • Publication number: 20200197235
    Abstract: The present disclosure relates to wearable articles having an elastic belt having arrays of elastic bodies.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
  • Patent number: 10646494
    Abstract: The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A?, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: May 12, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Wensheng Yu, Ling Tong, Joseph A. Kozlowski, Craig A. Coburn, De-Yi Yang, Deyou Sha, Jae-Hun Kim, Michael Dwyer, Kartik M Keertikar, Bin Hu, Bin Zhong, Jinglai Hao, Dahai Wang
  • Patent number: 10632025
    Abstract: A wearable article wherein least some of the elastic bodies may be arranged in at least 2 sets of a concentrated array defined as meeting: a) one concentrated array is formed by 2-4 elastic bodies; b) each elastic body within one concentrated array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific concentrated array disposed in an extra-interval between at least one neighboring elastic body outside the specific concentrated array of less than 8 mm. The entirety of the length of the belt side edge of the front belt may be seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may each divided into 4 zones wherein at least 2 concentrated arrays are disposed on the front proximal tummy zone or the back distal tummy zone.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 28, 2020
    Assignee: The Procter & Gamble Plaza
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng
  • Patent number: 10632024
    Abstract: Disclosed is a wearable article comprising a main body and a ring-like elastic belt comprising a front belt and a back belt. At least some of the elastic bodies may be arranged in an array, the array defined as meeting: a) one array is formed by 2-10 elastic bodies; b) each elastic body within one array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific array disposed in an extra-interval between at least one neighboring elastic bodies outside the specific array of greater than the inner-interval. Further, the front belt may comprise at least 5 arrays.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 28, 2020
    Assignee: The Procter & Gamble Plaza
    Inventors: Koichi Morimoto, Ling Tong, Chunmin Cheng