Patents by Inventor Ling X. Shen

Ling X. Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TARGETING RNA MOLECULES
    Publication number: 20150056612
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Application
    Filed: March 4, 2013
    Publication date: February 26, 2015
    Inventors: LING X. SHEN, GREGORY L. VERDINE, JAMES P. BASILION, VINCENT P STANTON, JR.
  • Methods for targeting RNA molecules
    Patent number: 8389484
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: March 5, 2013
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.
  • Methods for targeting RNA molecules
    Patent number: 7115372
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: October 3, 2006
    Assignee: Variagenics, Inc.
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.
  • Methods for targeting RNA molecules
    Patent number: 6686148
    Abstract: Methods are described for identifying an RNA target for an allele-specific RNA inhibitor by identifying a sequence variance in an RNA encoded by a gene of interest, and determining whether the secondary structure of the RNA comprising the variance differs from that of an otherwise identical RNA not comprising the variance.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: February 3, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.
  • Methods for targeting RNA molecules
    Publication number: 20030073123
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Application
    Filed: September 26, 2002
    Publication date: April 17, 2003
    Applicant: Variagenics, Inc., a Delaware corporation
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton