Abstract: Certain aspects of the present disclosure provide systems and methods for measuring eye-tissue biomechanics via blink stimulation. In certain embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes monitoring movement relative to an eye of a patient via one or more images from a camera. The method also includes detecting a blink of the eye of the patient responsive to the monitoring. The method also includes, responsive to the detected blink, recording data resultant from a scan, by the OCT device, of at least a portion of a tissue of the eye. The method also includes measuring a tissue response to the detected blink based on the recorded data from the scan.

Abstract: An optical coherence tomography (OCT) scanning system for measuring ocular tissue characteristics of a patient's eye. The system includes an OCT scanner configured to implement a scanning sequence on the ocular tissue that scans the ocular tissue with an optical signal to obtain OCT data based on a reflected version of the optical signal. The system includes a computer with a processor configured to provide control signals to the OCT scanner to implement the scanning sequence, and to determine a rate of change of the phase or amplitude data associated with the scans. The system determines a growth constant of the reflected version of the optical signal based on the rate of change of the phase or amplitude data, and determines, based on the growth constant, a diffusion coefficient associated with the cornea. The system determines, based on the diffusion coefficient, a quantitative parameter of the cornea.

Abstract: A system and method for corneal cross-linking with real-time monitoring are provided. The method comprises determining a plurality of measurement locations in a region of a cornea, and applying a corneal cross-linking treatment to the region of the cornea. During the application of the corneal cross-linking treatment, the method also comprises acquiring a temporal OCT interferogram at each OCT measurement location, generating temporal complex OCT data based on the temporal OCT interferogram, determining biomechanical data based on the temporal complex OCT data, and adjusting the corneal cross-linking treatment based on the biomechanical data.

Abstract: Certain aspects of the present disclosure provide systems and methods for measuring biomechanics in real-time at multiple eye-tissue locations. In certain embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes receiving an indication of a stimulus applied to eye tissue of a patient. The method also includes instructing the OCT device to emit a plurality of beams, at approximately the same time, to a plurality of measurement locations on the eye tissue in response to the received indication. The method also includes receiving, from the OCT device, OCT data for each of the plurality of measurement locations. The method also includes measuring tissue responses to the stimulus at the plurality of measurement locations based on the OCT data.

Abstract: Described herein include a system and method for a device for drug delivery and ophthalmic diagnostics designed to assist in the diagnosis of the physical state of a cornea through the projection of droplets onto the eye. In some embodiments, the apparatus includes a liquid sampling unit, an electric droplet generator, and a steering unit. In some embodiments, the liquid sampling unit is configured to project a quantity of liquid, while the electric droplet generator receives the quantity of liquid and outputs one or more electrically charged droplets. The steering unit uses electrostatic forces to steer the electrically charged droplets along a trajectory onto the cornea of the patient's eye.

Abstract: Systems and methods for measuring corneal biomechanical properties are provided. In certain embodiments, a method comprises determining a plurality of optical coherence tomography (OCT) measurement locations in a region of a cornea; for each OCT measurement location: applying a mechanical excitation to the cornea at the OCT measurement location, and measuring a response of the cornea to the mechanical excitation by acquiring temporal OCT data at the OCT measurement location; generating temporal deformation data for the region of the cornea based on the temporal OCT data at each OCT measurement location; and generating biomechanical data for the region of the cornea based on the temporal deformation data.

Abstract: A drug delivery device includes a drug delivery assembly configured to receive a portion of a head of a patient and mounted to a helmet or support. The drug delivery assembly includes one or more imaging devices configured to have an eye of the patient in a field of view thereof, an injection assembly configured to receive a drug to be injected, and a staging assembly including one or more actuators configured to position the injection assembly relative to the eye of the patient. A controller receives one or more images from the one or more imaging devices; detects a location of a limbus of the eye of the patient in the one or more images; and activate the one or more actuators to drive a needle into a placement location on the eye of the patient and dispense a drug into the eye through the needle.

Abstract: A filling composition comprises (A) a mineral oil having a kinematic viscosity from 80 cSt to 100 cSt at 40° C.; (B) a styrene-ethylene/propylene diblock copolymer; and (C1) a propylene/ethylene copolymer having a weight average molecular weight (Mw) from 5,000 to 200,000 or (C2) an ethylene/propylene copolymer having a weight average molecular weight (Mw) from 5,000 to 200,000. The filling composition is used as a filling composition in a buffer tube.

Abstract: Apparatuses, systems, and methods for treating tissue abnormalities are disclosed. The tissue may be visualized for determining a presence of one or more abnormalities contained therein. Imaging data obtained by visualization may be used to determine the presence of one or more abnormalities. Each of the detected abnormalities may be identified and a treatment plan developed for treating the abnormalities. Treatment may be delivered to the abnormalities according to the treatment plan.

Abstract: An ophthalmic surgical microscope includes a beam coupler positioned along an optical path of the surgical microscope between a first eyepiece and magnifying/focusing optics, the beam coupler operable to direct the OCT imaging beam along a first portion of the optical path of the surgical microscope between the beam coupler and a patient's eye (an OCT image being generated based on a reflected portion of the OCT imaging beam). The surgical microscope additionally includes a real-time data projection unit operable to project the OCT image generated by the OCT system and a beam splitter positioned along the optical path of the surgical microscope between a second eyepiece and the magnifying/focusing optics. The beam splitter is operable to direct the projected OCT image along a second portion of the optical path of the surgical microscope between the beam splitter and the second eyepiece such that the projected OCT image is viewable through the second eyepiece.

Abstract: A method and system provide an optical coherence tomography system including a light source, an interferometric system, a processor and a memory. The interferometric system is optically coupled with the light source and includes at least one movable scanning mirror. The processor and memory are coupled with the interferometric system. The processor executes instructions stored in the memory to cause the movable scanning mirror to scan a plurality of points in a sample in at least one pattern. The at least one pattern is based on at least one of at least one Lissajous curve and at least one Spirograph curve.

Abstract: A filling composition comprises (A) a mineral oil having a kinematic viscosity from 80 cSt to 100 cSt at 40° C.; (B) a styrene-ethylene/propylene diblock copolymer; and (C1) a propylene/ethylene copolymer having a weight average molecular weight (Mw) from 5,000 to 200,000 or (C2) an ethylene/propylene copolymer having a weight average molecular weight (Mw) from 5,000 to 200,000. The filling composition is used as a filling composition in a buffer tube.

Abstract: An ophthalmic surgical system includes a first imaging system configured to generate a first image of an eye, a second imaging system configured to generate a second image of the eye, and an image registration system to receive the first image generated by the first imaging system, receive the second image generated by a second imaging system, track a location of a distal tip of a surgical instrument in the first image, define a priority registration region in the first image, register the priority registration region in the first image with a corresponding region in the second image, and update the registration of the priority registration region in the first image with the corresponding region in the second image in real time, without registering portions of the first or second images that are outside the registration regions.

Abstract: Some embodiments of the present technology involve methods, devices, and systems for determining an orientation of a surgical tool during ophthalmic surgery. An example method includes performing an optical imaging scan in the surgical site, using a scan pattern that intersects the surgical tool and generating a scan image from the optical imaging scan. The example method further comprises analyzing the scan image to determine a location in the scan image corresponding to where the surgical tool intersected the optical imaging scan, and determining an orientation of the surgical tool, based on the determined location.

Abstract: A system and method for a reconfigurable surgical microscope is disclosed. The reconfigurable microscope includes an eyepiece; a relay lens system optically coupled to the eyepiece; a zoom lens system optically coupled to the eyepiece and the relay lens system; an illumination unit; and an objective lens capable of being repositioned between a first objective lens position and a second objective lens position, the first objective lens position comprising a slot located between the zoom lens system and the illumination unit and the second objective lens position comprising a slot located such that the illumination unit is located between the second objective lens position and the zoom lens system.

Abstract: Both visible and IR cameras are integrated without an increase in an optical stack height of a surgical microscope used for ophthalmic surgery. The IR camera may be used to directly and intraoperatively capture a scanning OCT measurement beam, which uses NIR light that is invisible to the human eye. An IR image from the IR camera taken from the same surgical field as displayed intraoperatively to a user of the surgical microscope may be displayed in an ocular to the user, enabling visualization of a location of an OCT scan along with actual visible images of the surgical field.

Abstract: A foot-operated controller includes a base configured to rest on a floor surface, and a movable contact surface coupled to the base. The contact surface includes an anterior region to support a toe region and a posterior region to support a heel region, and is configured to roll about a roll axis in response to inversion or eversion of a foot engaged with the contact surface, pitch about a pitch axis in response to plantar flexion or dorsiflexion of the foot, and yaw about a yaw axis in response to abduction or adduction of the foot. The roll, pitch, and yaw axes intersect at a point superior to the contact surface, and may align with the operator's ankle.

Abstract: An optical coherence tomography (OCT) apparatus includes an optical source module comprising two or more selectable optical sources or an optical source configured to selectively operate in two or more source operating modes, or a combination of both, and further comprises an OCT engine coupled to the optical source module, the OCT engine comprising an OCT interferometer. The OCT apparatus still further includes a mode-switching optics module coupled to the OCT engine and comprising one or more swappable, selectable, or adjustable optical components, such that the mode-switching optics module is configured to selectively provide two or more optical configurations for the optical path between the OCT engine and an imaged object, according to two or more corresponding operating modes.