Abstract: In at least one embodiment, an ophthalmic system includes a laser system, an adjustment system, an imaging system, and a computer system. The laser system has an optical axis. A z-axis is defined relative to the optical axis, and an xy-plane, with a central xy-point, is defined relative to the z-axis. The imaging system generates an eye image set comprising images of an eye. The computer system determines an xy-offset of the eye according to the eye image set, where the xy-offset of the eye is relative to the central xy-point. The computer system also determines a z-distance to the eye according to the eye image set, where the z-distance corresponds to the z-axis. The computer system then instructs the adjustment system to compensate for the xy-offset of the eye and to facilitate movement of the optical head towards the eye according to the z-distance.

Abstract: In at least one embodiment, an ophthalmic system comprises a laser system, an imaging system, and a computer system. The laser system provides a laser beam to perform a capsulotomy procedure on an eye. The laser system has an optical axis. The imaging system generates an image of the eye. The computer system determines a tilt-offset of the eye from the image of the eye, where the tilt-offset of the eye is relative to a z-axis corresponding to the optical axis. The computer system adjusts a capsulotomy pattern to compensate for the tilt-offset of the eye and instructs the laser system to provide the laser beam according to the capsulotomy pattern adjusted to compensate for the tilt-offset of the eye.

Abstract: Adjusting illumination sources based on stages of ophthalmic surgery is described. An ophthalmic surgical system may include a first illumination source configured to produce a first light beam for illuminating a surgical region of an eye, upon which an ophthalmic surgical procedure is being performed, from a first direction, and a second illumination source configured to produce a second light beam for illuminating the surgical region of the eye from a second direction. The ophthalmic surgical system may further include a surgical stage-based illumination module implemented in a non-transitory computer-readable storage medium and configured to determine, in real-time, a stage of the ophthalmic surgical procedure based on a detected trigger event. The surgical stage-based illumination module may be further configured to output, in real-time, instructions to adjust at least one of the first illumination source or the second illumination source based on the stage of the ophthalmic surgical procedure.

Abstract: The present disclosure relates to operations that include determining, based on a first optical imaging result obtained using an optical imaging system, one or more biomechanical properties of a target tissue corresponding to an eye. The operations may further include determining, based on the first optical imaging result, one or more geometric properties of the target tissue. The operations may further include generating a customized treatment plan for treatment of the target tissue based on the one or more biomechanical properties and the one or more geometric properties.

Abstract: In one or more embodiments, a laser system includes a first beam scanner and a second beam scanner. The first beam scanner receives a first laser beam along a first source-to-scanner path and scans the first laser beam in a first coordinate direction. The first beam scanner receives a second laser beam along a second source-to-scanner path, where the second source-to-scanner path is at a source angle relative to the first source-to-scanner path, and scans the second laser beam in the first coordinate direction. The second beam scanner receives the first laser beam from the first beam scanner along a scanner-to-scanner path and scans the first laser beam in a second coordinate direction. The second beam scanner receives the second laser beam from the first beam scanner along the scanner-to-scanner path and scans the second laser beam in the second coordinate direction.

Abstract: A system for guiding an ophthalmic procedure includes an optical coherence tomography (OCT) device configured to obtain respective data of a target site in an eye. The OCT device has a swept source laser tunable through a range of wavelengths. The OCT device includes a first imaging mode with a first imaging depth and a second imaging mode with a second imaging depth, the first imaging depth being greater than the second imaging depth. The controller is adapted to execute first and second sampling modules to process the respective OCT signal from the first and second imaging modes. The controller is adapted to generate an output signal indicative of at least one of pupil centering information and tilt angle of the target site based in part on the first dataset and the second dataset. The output signal is employed for pre-surgical alignment of the target site.

Abstract: In certain embodiments, an illuminator system provides illumination for a patient interface. The illuminator system includes input bundles, a fiber randomizer, and output bundles. The input bundles include a first input bundle and a second input bundle. The first input bundle includes first fibers, where each first fiber transmits a first light from a first light source. The second input bundle includes second fibers, where each second fiber transmits a second light from a second light source. The fiber randomizer receives the first fibers from the first input bundle, receives the second fibers from the second input bundle, and distributes the first and the second fibers among subsets of output fibers. Each subset of output fibers has at least one first fiber and at least one second fiber. Each output bundle includes a subset of output fibers and provides the first light and the second light to the patient interface.

Abstract: An ophthalmic surgical system includes a biomechanical imaging device configured to perform measurements of an eye of a patient. The system further includes a controller configured to: receive Brillouin light scattering (BLS) data from the BLS imaging device; calculate material properties according to the BLS data; select a tissue type according to the material properties; and generating an output corresponding to the tissue type. The biomechanical imaging device may include a confocal Brillouin microscope or a BLS spectrometer and a light source coupled to a fiber optic probe. Tissue types may include a retinal membrane, type of retinal membrane, or membrane-free area of the retina.

Abstract: A system includes an ophthalmic microscope configured to capture video of an ophthalmic treatment. A computer system is coupled to the ophthalmic microscope and is configured to: receive a first image from the ophthalmic microscope for a first wavelength band having a first width of less than 20 nanometers; receive a second image from the ophthalmic microscope for a second wavelength band having a second width of less than 20 nanometers; generate a vessel map of a retina of the eye of the patient according to the first image and the second image, the vessel map including representations of blood vessels of the retina; and display the vessel map on a display device. The computer system may further receive a reference image for an isosbestic wavelength band of oxygenated and de-oxygenated hemoglobin and generate the vessel map according to the reference image.

Abstract: A visualization system for use during an ophthalmic procedure. The system includes at least one illumination source configured to emit in a visible and an invisible light spectrum, a light filter configured to allow light within a filtered light spectrum, and an image sensor assembly configured to detect first and second sets of images from the visible and invisible light spectrums, respectively. The system also includes an electronic control unit (ECU) in communication with the at least one illumination source and the image sensor assembly. The ECU is programmed to activate the at least one illumination source to emit light in the visible and the invisible light spectrum and receive image data from the image sensor assembly representative of the first and second sets of images. The controller is also programmed to generate and display at least one composite image based on the first and second sets of images.

Abstract: A visualization system for use with an ophthalmic microscope having a pair of image sensors includes a first pair and multiple second pairs of interchangeable eyepieces each having a corresponding magnification level and field-of-view (FOV), and digital binoculars in communication with the image sensors. The digital binoculars include a housing configured to connect to the ophthalmic microscope and defining a housing cavity, a pair of annular bases connected to the housing configured to separately engage the first and multiple second pairs of interchangeable eyepieces to provide the FOV, and surrounding a corresponding center axis or designated position, and a pair of micro displays positioned within the housing cavity. Each respective one of the micro displays is arranged on the corresponding center axis or designated position.

Abstract: In certain embodiments, an ophthalmic diagnostics system includes a polarization sensitive optical coherence tomography (PS-OCT) device. The system also includes a memory having executable instructions. The system also includes a processor in communication with the memory and configured to execute the instructions to cause the PS-OCT device to emit polarized light to a measurement location on eye tissue of a patient and generate PS-OCT data based on the polarized light. The processor is further configured to execute the instructions to determine birefringent information for the measurement location based on the PS-OCT data and to determine biomechanics information for the measurement location based on the PS-OCT data. The processor is further configured to execute the instructions to determine a correlation between at least a portion of the biomechanics information and at least a portion of the birefringent information.

Abstract: Certain aspects of the present disclosure provide systems and methods for measuring eye-tissue biomechanics via blink stimulation. In certain embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes monitoring movement relative to an eye of a patient via one or more images from a camera. The method also includes detecting a blink of the eye of the patient responsive to the monitoring. The method also includes, responsive to the detected blink, recording data resultant from a scan, by the OCT device, of at least a portion of a tissue of the eye. The method also includes measuring a tissue response to the detected blink based on the recorded data from the scan.

Abstract: A system and method for corneal cross-linking with real-time monitoring are provided. The method comprises determining a plurality of measurement locations in a region of a cornea, and applying a corneal cross-linking treatment to the region of the cornea. During the application of the corneal cross-linking treatment, the method also comprises acquiring a temporal OCT interferogram at each OCT measurement location, generating temporal complex OCT data based on the temporal OCT interferogram, determining biomechanical data based on the temporal complex OCT data, and adjusting the corneal cross-linking treatment based on the biomechanical data.

Abstract: Certain aspects of the present disclosure provide systems and methods for measuring biomechanics in real-time at multiple eye-tissue locations. In certain embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes receiving an indication of a stimulus applied to eye tissue of a patient. The method also includes instructing the OCT device to emit a plurality of beams, at approximately the same time, to a plurality of measurement locations on the eye tissue in response to the received indication. The method also includes receiving, from the OCT device, OCT data for each of the plurality of measurement locations. The method also includes measuring tissue responses to the stimulus at the plurality of measurement locations based on the OCT data.

Abstract: Described herein include a system and method for a device for drug delivery and ophthalmic diagnostics designed to assist in the diagnosis of the physical state of a cornea through the projection of droplets onto the eye. In some embodiments, the apparatus includes a liquid sampling unit, an electric droplet generator, and a steering unit. In some embodiments, the liquid sampling unit is configured to project a quantity of liquid, while the electric droplet generator receives the quantity of liquid and outputs one or more electrically charged droplets. The steering unit uses electrostatic forces to steer the electrically charged droplets along a trajectory onto the cornea of the patient's eye.

Abstract: An optical coherence tomography (OCT) scanning system for measuring ocular tissue characteristics of a patient's eye. The system includes an OCT scanner configured to implement a scanning sequence on the ocular tissue that scans the ocular tissue with an optical signal to obtain OCT data based on a reflected version of the optical signal. The system includes a computer with a processor configured to provide control signals to the OCT scanner to implement the scanning sequence, and to determine a rate of change of the phase or amplitude data associated with the scans. The system determines a growth constant of the reflected version of the optical signal based on the rate of change of the phase or amplitude data, and determines, based on the growth constant, a diffusion coefficient associated with the cornea. The system determines, based on the diffusion coefficient, a quantitative parameter of the cornea.

Abstract: Systems and methods for measuring corneal biomechanical properties are provided. In certain embodiments, a method comprises determining a plurality of optical coherence tomography (OCT) measurement locations in a region of a cornea; for each OCT measurement location: applying a mechanical excitation to the cornea at the OCT measurement location, and measuring a response of the cornea to the mechanical excitation by acquiring temporal OCT data at the OCT measurement location; generating temporal deformation data for the region of the cornea based on the temporal OCT data at each OCT measurement location; and generating biomechanical data for the region of the cornea based on the temporal deformation data.

Abstract: A drug delivery device includes a drug delivery assembly configured to receive a portion of a head of a patient and mounted to a helmet or support. The drug delivery assembly includes one or more imaging devices configured to have an eye of the patient in a field of view thereof, an injection assembly configured to receive a drug to be injected, and a staging assembly including one or more actuators configured to position the injection assembly relative to the eye of the patient. A controller receives one or more images from the one or more imaging devices; detects a location of a limbus of the eye of the patient in the one or more images; and activate the one or more actuators to drive a needle into a placement location on the eye of the patient and dispense a drug into the eye through the needle.