Patents by Inventor Linghui Meng

Linghui Meng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240033066
    Abstract: Aspects of the disclosure relate methods and synthetic structural supports for regenerating gastrointestinal tissue (e.g., esophageal tissue).
    Type: Application
    Filed: August 1, 2023
    Publication date: February 1, 2024
    Inventors: William Fodor, Linghui Meng
  • Publication number: 20230037735
    Abstract: Aspects of the disclosure relate methods and a synthetic cell delivery device for treating trauma present relative to the inner surface of a hollow organ such as an esophagus.
    Type: Application
    Filed: October 10, 2022
    Publication date: February 9, 2023
    Inventors: Linghui Meng, Shunfu Hu, William Fodor
  • Patent number: 11464887
    Abstract: Aspects of the disclosure relate methods and a synthetic cell delivery device for treating trauma present relative to the inner surface of a hollow organ such as an esophagus.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: October 11, 2022
    Assignee: Biostage, Inc.
    Inventors: Linghui Meng, Shunfu Hu, William Fodor
  • Publication number: 20220257831
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hollow tubular organs present in the respiratory system such as bronchus tissue.
    Type: Application
    Filed: March 7, 2022
    Publication date: August 18, 2022
    Inventors: William Fodor, Linghui Meng, Sherif Soliman, Shunfu Hu
  • Publication number: 20220226097
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
    Type: Application
    Filed: January 31, 2022
    Publication date: July 21, 2022
    Inventors: Saverio Francesca, Sherif Soliman, Matthew Marsh, Shunfu Hu, Linghui Meng
  • Patent number: 11266763
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hallow organs present in the respiratory system such as bronchus tissue.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: March 8, 2022
    Assignee: Biostage, Inc.
    Inventors: William Fodor, Linghui Meng, Sherif Soliman, Shunfu Hu
  • Patent number: 11234805
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: February 1, 2022
    Assignee: Biostage, Inc.
    Inventors: Saverio La Francesca, Sherif Soliman, Matthew Marsh, Shunfu Hu, Linghui Meng
  • Publication number: 20200397559
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
    Type: Application
    Filed: May 1, 2020
    Publication date: December 24, 2020
    Inventors: Saverio La Francesca, Sherif Soliman, Shunfu Hu, Linghui Meng, David C. Rice, Ara A. Vaporciyan
  • Publication number: 20200114045
    Abstract: Aspects of the disclosure relate methods and a synthetic cell delivery device for treating trauma present relative to the inner surface of a hollow organ such as an esophagus.
    Type: Application
    Filed: October 4, 2019
    Publication date: April 16, 2020
    Inventors: Linghui Meng, Shunfu Hu, William Fodor
  • Publication number: 20200108173
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hallow organs present in the respiratory system such as bronchus tissue.
    Type: Application
    Filed: October 4, 2019
    Publication date: April 9, 2020
    Inventors: William Fodor, Linghui Meng, Sherif Soliman, Shunfu Hu
  • Publication number: 20200085557
    Abstract: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
    Type: Application
    Filed: September 9, 2019
    Publication date: March 19, 2020
    Inventors: Ron Sostek, David Green, Linghui Meng, Sherif Soliman, Joseph Consiglio
  • Patent number: 10449026
    Abstract: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: October 22, 2019
    Assignee: Biostage, Inc.
    Inventors: Ron Sostek, David Green, Linghui Meng, Sherif Soliman, Joseph Consiglio
  • Publication number: 20190284722
    Abstract: A multilayer scaffold device that includes a luminal electrospun layer, the luminal electrospun layer configured to provide a suitable environment to induce epithelium formation on the scaffold, an exterior electrospun layer, the exterior electrospun layer located radially exterior to the luminal electrospun layer, the exterior electrospun layer configured to induce formation of non-epithelial tissue; and at least one intermediate layer interposed between the luminal electrospun layer and that exterior electrospun layer, the intermediate layer configured to organize the formation of the respective epithelial tissue and the non-epithelial tissue.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 19, 2019
    Inventors: Sherif Soliman, Linghui Meng, Shunfu Hu
  • Patent number: 10236685
    Abstract: A power electronic voltage transforming apparatus is used in a two-phase to single-phase conversion. The power electronic voltage transforming apparatus is cooperatively used with a three-phase to two-phase transformer to convert the two-phase power output from the three-phase to two-phase transformer into single-phase power. The two-phase to single-phase power electronic voltage transforming apparatus or three-phase to single-phase power electronic voltage transforming apparatus has an input cascade connection structure formed by cascading n converter modules.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: March 19, 2019
    Assignee: SOUTHWEST JIAOTONG UNIVERSITY
    Inventors: Zeliang Shu, Linghui Meng, Wenjun Mao, Yuan Lei, Yi Qian, Xiaoqiong He
  • Publication number: 20180375326
    Abstract: The present invention provides a power electronic voltage transforming apparatus, which relates to the fields of electrified railway traction power supply technology, the industrial electricity etc. The power electronic voltage transforming apparatus can solve the problems of dynamic control of negative-sequence current, compensation of reactive power and phase separation of traction network, and can also solve the imbalance of voltage and current caused by adding single-phase load in other industrial power applications. The two-phase to single-phase power electronic voltage transforming apparatus or three-phase to single-phase power electronic voltage transforming apparatus has an input cascade connection structure formed by cascading n converter modules.
    Type: Application
    Filed: November 2, 2017
    Publication date: December 27, 2018
    Applicant: Southwest Jiaotong University
    Inventors: Zeliang SHU, Linghui MENG, Wenjun MAO, Yuan LEI, Yi QIAN, Xiaoqiong HE
  • Patent number: 9683011
    Abstract: A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20×) can be added to the solution until the volume ratio of PBS buffer (20×) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: June 20, 2017
    Assignee: Case Western Reserve University
    Inventors: Gary E. Wnek, Linghui Meng
  • Publication number: 20170135796
    Abstract: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
    Type: Application
    Filed: October 25, 2016
    Publication date: May 18, 2017
    Inventors: Ron Sostek, David Green, Linghui Meng, Sherif Soliman, Joseph Consiglio
  • Patent number: 9040665
    Abstract: A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20×) can be added to the solution until the volume ratio of PBS buffer (20×) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: May 26, 2015
    Assignee: Case Western Reserve University
    Inventors: Gary Wnek, Linghui Meng
  • Publication number: 20130023648
    Abstract: A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20X) can be added to the solution until the volume ratio of PBS buffer (20X) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.
    Type: Application
    Filed: March 26, 2012
    Publication date: January 24, 2013
    Inventors: Gary Wnek, Linghui Meng