Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: The present disclosure provides a chimeric antigen receptor (CAR) specific for albumin. The present disclosure also provides compositions comprising the CAR, polynucleotides encoding the CAR, vectors comprising a polynucleotide encoding the CAR, engineered cells comprising the CAR, and method using the same.

Abstract: A computer system includes memory hardware configured to store a multitask neural network, an optimization model, a material database, material feature vector inputs, and computer-executable instructions which include training the multitask neural network with the material feature vector inputs to generate a material structural parameter output, obtaining at least one of a target optical perception parameter and a target optical response, supplying the target optical perception parameter or target optical response and at least two of the multiple material data structures of the material database to the multitask neural network to output the at least one predicted material and the predicted structural parameter distribution, processing, by the optimization model, the predicted structural parameter distribution to generate a tuned structural parameter output, and transmitting the at least one predicted material and the tuned structural parameter output to a computing device to facilitate generation of an optica

Abstract: An anti-crash helicopter seat integrating multiple protections, including a main framework, a weighing sensor, a magnetorheological damper system, an upper body forced tensioning and quick disengagement system, a seat pan, a multifunctional vest and a controller, wherein the seat pan is slidably connected with the main framework in a vertical direction, the magnetorheological damper system is fixedly arranged on the seat pan and is connected with the main framework by the weighing sensor, the upper body forced tensioning and quick disengagement system is arranged on the seat pan, the multifunctional vest is connected with the seat pan by the upper body forced tensioning and quick disengagement system, and the controller is connected with the weighing sensor and the magnetorheological damper system respectively.

Abstract: Provided by the present invention relates to the field of optical technology and is a symmetric imaging plane free-form surface optical system having a two-dimensional large field of view comprising a first reflector, a second reflector, a third reflector, a fourth reflector and a detector imaging plane which are arranged along a light path direction in sequence, and further comprising an aperture stop, wherein a position wherein the aperture stop is located at is overlapped with a position wherein the second reflector is located at such that a light beam is allowed to be reflected by the first reflector to the second reflector, after reflected by the second reflector then is injected to the third reflector, after reflected by the third reflector then is injected to the fourth reflector, after reflected by the fourth reflector then is injected to the imaging surface of the detector for imaging.

Abstract: A transmitter optical subassembly is disclosed including a substrate and a direct modulated laser disposed on the substrate. A single-stage isolator, a polarization direction rotator, and an optical branching filter are disposed side by side on the substrate in a light propagation direction. The polarization direction rotator can adjust linearly polarized light to P-polarized light, the optical branching filter includes an optical splitter subassembly and a filter subassembly, and an optical splitter film in the optical splitter subassembly is an optical splitter film with P polarization. The polarization direction rotator adjusts the incident linearly polarized light to the P-polarized light, and the optical splitter film in the optical branching filter is the optical splitter film with P polarization; all P-polarized light with single polarization can pass through the optical branching filter, without causing any polarization loss or two peaks.

Abstract: A transmitter optical subassembly is disclosed including a substrate and a direct modulated laser disposed on the substrate. A single-stage isolator, a polarization direction rotator, and an optical branching filter are disposed side by side on the substrate in a light propagation direction. The polarization direction rotator can adjust linearly polarized light to P-polarized light, the optical branching filter includes an optical splitter subassembly and a filter subassembly, and an optical splitter film in the optical splitter subassembly is an optical splitter film with P polarization. The polarization direction rotator adjusts the incident linearly polarized light to the P-polarized light, and the optical splitter film in the optical branching filter is the optical splitter film with P polarization; all P-polarized light with single polarization can pass through the optical branching filter, without causing any polarization loss or two peaks.

Abstract: Embodiments of the present invention disclose an optical transmitter, a 10 G-DML, an MPD 1, an MPD 2, a collimation lens, and a narrowband optical filter are disposed in a TO to achieve monitoring of an optical power, received optical powers are monitored by using the MPD 1 and the MPD 2, the detected optical powers are output to a wavelength locking monitoring circuit by using a TO pin, variations, which are detected by the wavelength locking monitoring circuit, of the optical power and a variation of a wavelength locking factor K0 are separately compared with corresponding thresholds, and a comparison result are sent to a wavelength locking control circuit, to enable the wavelength locking control circuit to adjust, according to the comparison result and by using the TO pin, a temperature of a TEC to perform wavelength alignment.

Abstract: Embodiments of the present invention disclose an optical transmitter, a 10 G-DML, an MPD 1, an MPD 2, a collimation lens, and a narrowband optical filter are disposed in a TO to achieve monitoring of an optical power, received optical powers are monitored by using the MPD 1 and the MPD 2, the detected optical powers are output to a wavelength locking monitoring circuit by using a TO pin, variations, which are detected by the wavelength locking monitoring circuit, of the optical power and a variation of a wavelength locking factor K0 are separately compared with corresponding thresholds, and a comparison result are sent to a wavelength locking control circuit, to enable the wavelength locking control circuit to adjust, according to the comparison result and by using the TO pin, a temperature of a TEC to perform wavelength alignment.