Abstract: Provided are PROTACs comprised of a targeting moiety designed to bind KRAS (G12D) linked to a degrader-directing moiety designed to bind an E3 ubiquitin-ligase. Pharmaceutical compositions comprising the disclosed PROTACs and their use in treating cancer and related conditions are also provided.

Abstract: The present disclosure relates to the field of new materials, and aims at providing an A-site high-entropy nanometer metal oxide with high conductivity, and a preparation method thereof. The metal oxide has molecular formula of Gd0.4Er0.3La0.4Nd0.5Y0.4)(Zr0.7, Sn0.8, V0.5)O7 and is a powder, and has microstructure of the metal oxide as a square nanometer sheet with a side length of 4-12 nm and a thickness of 1-3 nm. Compared with an existing high-entropy oxide, the product in the present disclosure has high conductivity, and can be well applied to a conductive alloy, an electrical contact composite material, a conductive composite material, a multifunctional bio-based composite material, a conductive/antistatic composite coating and the like.

Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A distributor for a plate heat exchanger includes a tube part having a tube wall and having a first end and a second end; a first flange formed at the first end; and a connecting protrusion. The connecting protrusion projects from the tube wall of the tube part in a direction away from an axis of the tube part, and projects from the first flange at the inside of the outer edge of the first flange in a direction towards the second end of the tube part; the connecting protrusion has a connecting protrusion wall, which has an axial connecting protrusion wall that faces in the axial direction of the tube part and is remote from the first flange, the axial connecting protrusion wall being between the first end and the second end of the tube part, and having at least one through-hole.

Abstract: The present disclosure relates to the field of new materials, and aims at providing an A-site high-entropy nanometer metal oxide with high conductivity, and a preparation method thereof. The metal oxide has molecular formula of Gd0.4Er0.3La0.4Nd0.5Y0.4)(Zr0.7, Sn0.8, V0.5)O7 and is a powder, and has microstructure of the metal oxide as a square nanometer sheet with a side length of 4-12 nm and a thickness of 1-3 nm. Compared with an existing high-entropy oxide, the product in the present disclosure has high conductivity, and can be well applied to a conductive alloy, an electrical contact composite material, a conductive composite material, a multifunctional bio-based composite material, a conductive/antistatic composite coating and the like.

Abstract: The present disclosure relates to the field of new materials, and aims at providing an A-site high-entropy nanometer metal oxide with high conductivity, and a preparation method thereof. The metal oxide has molecular formula of Gd0.4Er0.3La0.4Nd0.5Y0.4)(Zr0.7, Sn0.8, V0.5)O7 and is a powder, and has microstructure of the metal oxide as a square namometer sheet with a side length of 4-12 nm and a thickness of 1-3 nm. Compared with an existing high-entropy oxide, the product in the present disclosure has high conductivity, and can be well applied to a conductive alloy, an electrical contact composite material, a conductive composite material, a multifunctional bio-based composite material, a conductive/antistatic composite coating and the like.

Abstract: Provided are compounds of Formula: H-L-T and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A heat exchanger assembly (100), the heat exchanger assembly (100) comprising: a first heat exchanger (1), the first heat exchanger (1) comprising a first communicating header pipe (10), a first header pipe (12), and heat exchange tubes (9) arranged between the first communicating header pipe (10) and the first header pipe (12); and a second heat exchanger (2), the second heat exchanger (2) comprising a second communicating header pipe (20), a second header pipe (22), and heat exchange tubes (9) arranged between the second communicating header pipe (20) and the second header pipe (22), wherein the first communicating header pipe (10) is provided with a partition plate (30) and thus has a plurality of first communicating chambers (14) arranged in the axial direction of the first communicating header pipe (10), the second communicating header pipe (20) is provided with a partition plate (30) and thus has a plurality of second communicating chambers (24) arranged in the axial direction of the second communicatin

Abstract: A plate heat exchanger includes heat exchange plates and a port, and the port communicates with a predetermined heat exchange space of a plurality of heat exchange spaces. The heat exchange plates of the plate heat exchanger includes a plurality of first heat exchange plates and a plurality of second heat exchange plates. The first heat exchange plate includes: a first heat exchange plate main body; a first opening formed in the first heat exchange plate main body for forming the port; and a first annular protrusion surrounding the first opening, adjoining the first opening and protruding from the first heat exchange plate main body toward a first side in a stacking direction.

Abstract: The present disclosure relates to the field of new materials, and aims at providing a two-dimensional high-entropy metal oxide assembly with high thermal conductivity and a preparation method thereof. The two-dimensional high-entropy metal oxide assembly with the high thermal conductivity has a molecular formula of (Co0.3La0.6Er0.6Y0.7Mn0.4Ga0.4)O4. The two-dimensional high-entropy metal oxide assembly with the high thermal conductivity is in a short fiber shape with a length-diameter ratio of the short fiber of 5 to 7 and has a cross section of a regular triangle with the side length of the regular triangle of 100 to 300 nm. The present disclosure achieves one-dimensional high thermal conductivity of metal oxide assembly by means of orderly assembling of high-entropy oxide in the direction perpendicular to nanosheets. Meanwhile, the assembly enables uniform distribution of heterogeneous elements in the two-dimensional plane during the preparation process.

Abstract: The present disclosure relates to the field of new materials, and aims at providing an A-site high-entropy nanometer metal oxide with high conductivity, and a preparation method thereof. The metal oxide has molecular formula of Gd0.4Er0.3La0.4Nd0.5Y0.4)(Zr0.7, Sn0.8, V0.5)O7 and is a powder, and has microstructure of the metal oxide as a square namometer sheet with a side length of 4-12 nm and a thickness of 1-3 nm. Compared with an existing high-entropy oxide, the product in the present disclosure has high conductivity, and can be well applied to a conductive alloy, an electrical contact composite material, a conductive composite material, a multifunctional bio-based composite material, a conductive/antistatic composite coating and the like.

Abstract: Disclosed in the present invention are a distributor for a plate heat exchanger, and a plate heat exchanger. The distributor includes; a tube part having a tube wall and having a first end and a second end; a first flange formed at the first end; and a connecting protrusion. The connecting protrusion projects from the tube wall of the tube part in a direction away from an axis of the tube part, and projects from the first flange at the inside of the outer edge of the first flange in a direction towards the second end of the tube part; the connecting protrusion has a connecting protrusion wall, which has an axial connecting protrusion wall that faces in the axial direction of the tube part and is remote from the first flange, the axial connecting protrusion wall being between the first end and the second end of the tube part, and having at least one through-hole.

Abstract: A heat exchanger assembly (100), the heat exchanger assembly (100) comprising: a first heat exchanger (1), the first heat exchanger (1) comprising a first communicating header pipe (10), a first header pipe (12), and heat exchange tubes (9) arranged between the first communicating header pipe (10) and the first header pipe (12); and a second heat exchanger (2), the second heat exchanger (2) comprising a second communicating header pipe (20), a second header pipe (22), and heat exchange tubes (9) arranged between the second communicating header pipe (20) and the second header pipe (22), wherein the first communicating header pipe (10) is provided with a partition plate (30) and thus has a plurality of first communicating chambers (14) arranged in the axial direction of the first communicating header pipe (10), the second communicating header pipe (20) is provided with a partition plate (30) and thus has a plurality of second communicating chambers (24) arranged in the axial direction of the second communicatin

Abstract: A method for preparing an ultra-long-tube type fine-grain molybdenum tube target uses molybdenum powder with the purity being greater than 3N to prepare a target tube with a uniform wall thickness, where the length is 1700-2700 mm; the diameter is greater than 150 mm; and the wall thickness is 15-40 mm. The method includes: taking molybdenum powder, feeding the molybdenum powder into a film, molding by static pressing, placing in a medium frequency furnace, performing hydrogen sintering to form a tube blank, placing into a mold, forging the mold of a tube target, placing into tempering furnace, annealing, forming fine-grain structures, fine processing, washing, and drying to prepare a molybdenum tube target. The method overcomes defects of a sintering process and a forging process, and relates to simple processes, easy industrial production and control, reduced pollution, reduced cost, improved quality, and remarkably improved production efficiency.

Abstract: A method for preparing an ultra-long-tube type fine-grain molybdenum tube target uses molybdenum powder with the purity being greater than 3N to prepare a target tube with a uniform wall thickness, where the length is 1700-2700 mm; the diameter is greater than 150 mm; and the wall thickness is 15-40 mm. The method includes: taking molybdenum powder, feeding the molybdenum powder into a film, molding by static pressing, placing in a medium frequency furnace, performing hydrogen sintering to form a tube blank, placing into a mold, forging the mold of a tube target, placing into tempering furnace, annealing, forming fine-grain structures, fine processing, washing, and drying to prepare a molybdenum tube target. The method overcomes defects of a sintering process and a forging process, and relates to simple processes, easy industrial production and control, reduced pollution, reduced cost, improved quality, and remarkably improved production efficiency.