Abstract: The present application provides a preparation method for biosynthesis of a human body structural material. A polypeptide has the amino acid sequence of SEQ ID NO. 4, 5 or 6. Recombinant type-VII humanized collagen prepared in the present application has high activity of promoting cell proliferation and does not produce an immune response when applied to a human body, and the preparation method therefor is novel and can obtain the recombinant type-VII humanized collagen on a large scale, and is widely applied in the preparation of human body structural materials.

Abstract: Provided is collagen and uses thereof. Collagen includes an N-terminal sequence and a C-terminal sequence, wherein the N-terminal sequence includes one or more repeating units, and the repeating unit includes an amino acid sequence shown in SEQ ID NO. 15. The recombinant type II humanized collagen prepared by the present invention has high activity in promoting cell adhesion, does not produce an immune response when applied to the human body, can be obtained on a large scale, and is expected to be widely used in the field of cartilage repair.

Abstract: A display panel and a manufacturing method thereof are provided. The display panel includes a thin film transistor. The thin film transistor includes a channel, a first conductive portion and a second conductive portion disposed on two sides of the channel, an interlayer insulation layer, a first electrode, and a second electrode. Wherein, the display panel includes a first via hole and a second via hole, the first via hole penetrates through the interlayer insulation layer and exposes a surface and a side of the first conductive portion, a first light-shielding conductive element is filled in the first via hole, the second via hole penetrates through the interlayer insulation layer and exposes a surface and a side of the second conductive portion, and the second light-shielding conductive element is filled in the second via hole.

Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.

Abstract: A configurable control loop arrangement for forming a control loop of a DC-DC converter that is configured to generate a control signal to control the DC-DC converter, the configurable control loop arrangement comprising: a digital-to-analog converter; a comparator; a timer configured to provide a timing-signal for controlling one or more of: the comparator in the determination of the comparison signal; the application of the comparison signal to a configurable-event-generation-logic-module; and the operation of the configurable-event-generation-logic-module; wherein the configurable-event-generation-logic-module comprises a flip-flop circuit, and wherein the configurable-event-generation-logic-module, when implemented in the control loop, is configured to provide for generation of the control signal based on the comparison signal, the timing-signal and a selected mode of the flip-flop circuit, and wherein the control signal is for application to one or more switches of the DC-DC converter.

Abstract: A method and system for calculating the free energy difference between a target state and a reference state. The method includes determining one or more intermediate states using a coupling parameter, performing molecular simulations to obtain ensembles of micro-states for each of the system states, and calculating the free energy difference by an analysis of the ensembles of micro-states of the system states. The method can be particularly suited for calculating physical or non-physical transformation of molecular systems such as ring-opening, ring-closing, and other transformations involving bond breaking and/or formation. A soft bond potential dependent on a bond stretching component of the coupling parameter and different from the conventional harmonic potential is used in the molecular simulations of the system states for the bond being broken or formed during the transformation.

Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.

Abstract: The present disclosure provides an electric jack with a current limiting protector, which relates to the technical field of mechanical equipment. The electric jack with the current limiting protector includes: a current limiting protector, a four-pin double-reset switch, a control motor, and a supporting leg main body. The current limiting protector is connected in parallel to the control motor through the four-pin double-reset switch. The current limiting protector, the four-pin double-reset switch, and the control motor are detachably mounted on the supporting leg main body. A first wiring terminal, a second wiring terminal, a third wiring terminal, a fourth wiring terminal, a fifth wiring terminal, and a current limiting protection circuit are distributed on the current limiting protector.

Abstract: Mitoxantrone hydrochloride liposome is a unique active ingredient for preparing drugs for treating breast cancer. The breast cancer is preferably advanced breast cancer. A method for treating the breast cancer includes to administer mitoxantrone hydrochloride liposome in a therapeutic effective amount to breast cancer patients, and the therapeutic effective amount means 8-30 mg/m2, according to mitoxantrone. Clinical trial results show that the mitoxantrone hydrochloride liposome has better efficacy and fewer adverse reactions, and especially significantly reduced cardiotoxicity, compared with a common mitoxantrone hydrochloride injection.

Abstract: A method and system for calculating the free energy difference between a target state and a reference state. The method includes determining one or more intermediate states using a coupling parameter, performing molecular simulations to obtain ensembles of micro-states for each of the system states, and calculating the free energy difference by an analysis of the ensembles of micro-states of the system states. The method can be particularly suited for calculating physical or non-physical transformation of molecular systems such as ring-opening, ring-closing, and other transformations involving bond breaking and/or formation. A soft bond potential dependent on a bond stretching component of the coupling parameter and different from the conventional harmonic potential is used in the molecular simulations of the system states for the bond being broken or formed during the transformation.

Abstract: A flocculating, grading, and dewatering device includes a tank body, a mixing zone, a flocculent settling zone, a centrifugal dewatering zone, and a particle screening zone. An initial material is mixed with a chemical agent for a flocculation reaction, a lower sediment material settles and an upper liquid overflows. In the centrifugal dewatering zone, a screen basket is allowed to rotate to facilitate a centrifugal movement of the sediment material, water in the sediment material moves into a guide cavity and then flows to a centrifugate outlet, and then a dewatered material in the screen basket is removed out of the screen basket. In the particle screening zone, a screening mechanism screens particles of different size grades in the dewatered material, and water generated flows downward and is discharged; liquids discharged from the centrifugate outlet and the overflow port are combined, and then discharged through a mixed liquid outlet.

Abstract: A time-resolved fluorescence and chromogenic dual-signal test strip for estrogen is based on the principle of immune recognition and fluorescence resonance energy transfer. In time-resolved fluorescence mode, estrogen-BSA-persistent luminescence particle complex is the fluorescence donor, and colloidal gold modified with estrogen monoclonal antibody is the fluorescence receptor, which is also chromogenic signal unit in the chromogenic mode. The photos of strips in both modes are obtained with smart phones. The time-resolved fluorescence intensity of the test strip test zone is positively correlated with estrogen content, and the chromogenic intensity is negatively correlated with estrogen content. The competitive time-resolved fluorescence and chromogenic dual-signal immunochromatographic test strips can accurately and quickly detect estrogen and estrogen-like compounds.

Abstract: A double-lifting device for a towing type traveling vehicle, has an active leg, a driven leg, a transmission member, a geared motor, a gear reduction structure, a first reverse gear reduction structure, and a second reverse gear reduction structure; the geared motor, the gear reduction structure, and the first reverse gear reduction structure are sequentially and drivably connected; the output end of the gear reduction structure is also used to drive the transmission member, and the transmission member is used to drive the second reverse gear reduction structure. The double-lifting device is able to achieve synchronous lifting and lowering. With a simple structure, ifs stable, easy to operate, and provides mechanical overload protection.

Abstract: A configurable control loop arrangement for forming a control loop of a DC-DC converter that is configured to generate a control signal to control the DC-DC converter, the configurable control loop arrangement comprising: a digital-to-analog converter; a comparator; a timer configured to provide a timing-signal for controlling one or more of: the comparator in the determination of the comparison signal; the application of the comparison signal to a configurable-event-generation-logic-module; and the operation of the configurable-event-generation-logic-module; wherein the configurable-event-generation-logic-module comprises a flip-flop circuit, and wherein the configurable-event-generation-logic-module, when implemented in the control loop, is configured to provide for generation of the control signal based on the comparison signal, the timing-signal and a selected mode of the flip-flop circuit, and wherein the control signal is for application to one or more switches of the DC-DC converter.

Abstract: The present disclosure provides a display panel and preparing method thereof, and a display apparatus. In one or more embodiments, the display panel includes a substrate that includes an off-screen camera region including a plurality of opening regions, a flexible layer located at a side of the substrate, a backplate layer located at a side of the flexible layer away from the substrate and including a plurality of light-transmitting film layers, and a light-emitting device layer located at a side of the backplate layer away from the substrate and including a plurality of cathodes. An orthographic projection of the flexibly layer on the substrate is not overlapped with the opening regions. An orthographic project of at least one light-transmitting film layer on the substrate covers the opening regions. Orthographic projections of the cathodes on the substrate are not overlapped with the opening regions.

Abstract: An object blocking method, a terminal, a server, and a storage medium are provided. The method includes: sending, when whether to block a target object cannot be determined according to a first blocking strategy library, feature information of the target object to a server. The feature information instructs the server to generate a target blocking strategy according to the feature information and feed back the target blocking strategy. The method also includes: receiving the target blocking strategy fed back by the server; adding the target blocking strategy to the first blocking strategy library; and performing subsequent object blocking according to the first blocking strategy library added with the target blocking strategy, including: determining whether to block the target object according to the target blocking strategy in the first blocking strategy library.

Abstract: A safeguarding method, a safeguarding apparatus, and a computer storage medium are provided. The method includes detecting a program operating on a terminal, and intercepting an operation performed by the program; identifying an object on which the program performs the operation; obtaining configuration information of the object on the terminal, and determining, based on the configuration information, that the object is a targeted monitored object. The method further includes determining, based on the configuration information of the targeted monitored object, whether the operation performed by the program on the object is a legitimate operation; and canceling intercepting the operation if the operation is a legitimate operation, and continuously intercepting the operation if the operation is an illegitimate operation.

Abstract: A preparation method and uses of a high-performance water-soluble acrylic resin with high solid content and low viscosity. The method polymerizes the free radical solution in a mixed solvent by a continuous method to produce an acrylic resin and the resin is rendered water-soluble through salification. Modification with versatate introduces a large branched structure. Silicone functional monomer is used to modify the acrylic resin. Amino resin is used as a curing agent to directly prepare a waterborne amino-acrylic coating with a simple process, and the coating has good hardness, fullness, water and alcohol resistance and salt spray resistance.

Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.

Abstract: A method for computing free energy difference between a reference molecule and a target molecule. The target molecule has the common set of atoms PAB and a set of atoms PB. The method includes applying a potential to restrain an interaction of the additional atomic component from the set of atoms PB with the common set of atoms PAB in the initial state. The method includes determining one or more transition states along a transformation path between the initial state and target state. The method includes scaling the restrain potential correspondingly along the transformation path until the potential becomes zero when a corresponding end state is reached, and calculating the free energy difference between the reference molecule and the target molecule using a value obtained along the transformation path from the initial state to the target state.