Abstract: The present invention relates to the field of biomedicine, in particular, to an improved circular RNA and a preparation method thereof, wherein the improved circular RNA has high generation efficiency and reduced immunogenicity. The present invention also relates to a vector for the preparation of the improved circular RNA, and the use of the improved circular RNA.

Abstract: A related substance of linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline, 4,4?-(2-methylpropane-1,3-diyl)bis(2-(chloromethyl)quinazoline) and a method for synthesizing the related substance (impurity) by reacting 2-(chloromethyl)-4-methylquinazoline with acetaldehyde under an alkaline condition and a purification method are provided. The preparation method is simple and convenient to operate, short in reaction time, high in product purity, and high in yield. The synthesized related substance can be used for qualitative and quantitative analysis of the linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline and API impurities of linagliptin, so that the medication safety of the linagliptin is improved.

Abstract: A plant-based electrochemical device for ecological restoration of a polluted river or lake and a using method thereof are provided. The plant-based electrochemical device includes a sediment, where a plurality of first electrodes are provided in the sediment, the plurality of first electrodes each include a plurality of staggered cylinders, an outer side of each of the plurality of cylinders is provided with an electrically-conductive layer, and the electrically-conductive layer is electrically connected to an external power supply; a plurality of upright posts are symmetrically fixed in the sediment, the plurality of upright posts are fixedly connected to a second electrode through a fixing mechanism, and the second electrode is located at a water surface and is electrically connected to the external power supply; and a plurality of ecological landscape floating islands are provided on the water surface.

Abstract: The present disclosure relates to the technical field of display screen, and provides a display module set and a display screen. The display module set comprises a cabinet frame and a plurality of display modules. The cabinet frame comprises a power box and a plurality of sub-frames located on the left and right sides of the power box. The sub-frames on each side are arranged sequentially in a vertical direction. The plurality of the display modules corresponds to a plurality of the sub-frames on a one-to-one basis. A drive circuit and mounting members of the display module are both provided on a left side and/or right side region. A middle region of the display module is uniformly distributed with a hole structure for sound transmission. The display module is mounted on a corresponding sub-frame via the mounting members of the left side and/or right side region.

Abstract: A micro-power wireless access method and apparatus for the Internet of things for power transmission and transformation equipment involves a time synchronization process, a traffic channel access process, a control channel configuration information access process, and a control channel burst information access process. In the time synchronization process, an aggregation node determines a delay parameter and other parameters based on a timeslot in which traffic information randomly transmitted by a sensing terminal is located, and the sensing terminal adjusts transmission time of a corresponding frame based on the parameters. The traffic channel access process adopts a mode in which one-way reporting is mainly used, to minimize working time of a sensor. The present disclosure realizes limited two-way communication on a control channel, supports configuration of a sensor cycle, a threshold, and other parameters, and supports a retransmission mechanism on the control channel for important alarm information.

Abstract: A micro-power wireless access method and apparatus for the Internet of things for power transmission and transformation equipment involves a time synchronization process, a traffic channel access process, a control channel configuration information access process, and a control channel burst information access process. In the time synchronization process, an aggregation node determines a delay parameter and other parameters based on a timeslot in which traffic information randomly transmitted by a sensing terminal is located, and the sensing terminal adjusts transmission time of a corresponding frame based on the parameters. The traffic channel access process adopts a mode in which one-way reporting is mainly used, to minimize working time of a sensor. The present disclosure realizes limited two-way communication on a control channel, supports configuration of a sensor cycle, a threshold, and other parameters, and supports a retransmission mechanism on the control channel for important alarm information.

Abstract: A current stimulation device and an osteoblast differentiation treatment system through current stimulation are provided, which relate to the technical field of bioengineering. The current stimulation device includes a nanogenerator, which is electrically connected to a stimulation electrode. The stimulation electrode makes contact with an affected part. The stimulation of the present disclosure is applied to the affected part of a fracture patient, and realizes the current stimulation through the nanogenerator, promotes proliferation and activity of the osteoblast. The present disclosure provides a new idea for fracture healing, and promotes application progress of the nanogenerator in a wearable electronic medical instrument. The present disclosure has portability and an excellent clinical application prospect.

Abstract: A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.

Abstract: Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.

Abstract: Provided are training method for descreening system, descreening method, device, apparatus and medium. The training method for descreening system comprises: obtaining a first error function based on a halftone position and a preset label value, obtaining a second error function based on simulation images and non-halftone training samples, obtaining a third error function and a fourth error function according to a discrimination result, obtaining a fifth error function according to feature A and feature B, and based on the characteristics of Generative Adversarial Networks, according to the second error function, third error function, fourth error function and fifth error function, the sixth error function and seventh error function are respectively obtained, then an error function is constructed according to the errors generated by training, and the network parameters of each part of the models in the descreening system are updated by backpropagation of error function.

Abstract: The present application relates an automatically arranged emergency shipwreck position-indicating buoy, which belongs to the technical field of navigation (ship) aids. The automatically arranged emergency shipwreck position-indicating buoy comprises a gasbag, a rope, a high-pressure gas storage device, and a position-indicating light assembly; a rear end of the rope is wound onto a shaft arranged on the gasbag and a front end of the rope is arranged on a ship; a gas outlet of the high-pressure gas storage device is communicated with a gas inlet of the gasbag, and a sealing device is arranged at the gas outlet of the high-pressure gas storage device, and the sealing device is connected to the rope by a connector so as to be arranged on the ship; the position-indicating light assembly is arranged above the gasbag.

Abstract: The present application relates an automatically arranged emergency shipwreck position-indicating buoy, which belongs to the technical field of navigation (ship) aids. The automatically arranged emergency shipwreck position-indicating buoy comprises a gasbag, a rope, a high-pressure gas storage device, and a position-indicating light assembly; a rear end of the rope is wound onto a shaft arranged on the gasbag and a front end of the rope is arranged on a ship; a gas outlet of the high-pressure gas storage device is communicated with a gas inlet of the gasbag, and a sealing device is arranged at the gas outlet of the high-pressure gas storage device, and the sealing device is connected to the rope by a connector so as to be arranged on the ship; the position-indicating light assembly is arranged above the gasbag.